Search results for: Gwonhwa Song

Items from 1 to 20 out of 70 results

article

Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs

Sunwoo Park, Jiyeon Ham, Changwon Yang, Wonhyoung Park, more

Journal of Pineal Research > 74 > 1 > n/a - n/a

Endometriosis is a benign gynecological disease characterized by abnormal growth of endometrial‐like cells outside the uterus. Melatonin, a hormone secreted by the pineal gland, has been shown to have therapeutic effects in various diseases, including endometriosis. However, the underlying molecular mechanisms are yet to be elucidated. The results of this study demonstrated that melatonin and dienogest...

article

Fraxetin induces cell death in colon cancer cells via mitochondria dysfunction and enhances therapeutic effects in 5‐fluorouracil resistant cells

Minkyeong Lee, Changwon Yang, Sunwoo Park, Gwonhwa Song, more

Journal of Cellular Biochemistry > 123 > 2 > 469 - 480

Fraxetin is a natural compound extracted from Fraxinus spp. and has various functions such as antibacterial, antioxidant, neuroprotective, and antifibrotic effects. Although studies have reported its anticancer properties in lung and breast cancer, little is known about colon cancer, the most frequent type of cancer. Thus, we used two colon cancer cell lines, HT29 and HCT116 cells, to investigate...

article

Osthole interacts with an ER‐mitochondria axis and facilitates tumor suppression in ovarian cancer

Hyocheol Bae, Jin‐Young Lee, Jisoo Song, Gwonhwa Song, more

Journal of Cellular Physiology > 236 > 2 > 1025 - 1042

Osthole is a natural coumarin found in a variety of plants and has been reported to have diverse biological functions, including antimicrobial, antiviral, immunomodulatory, and anticancer effects. Here, we investigated the natural derivative osthole as a promising anticancer compound against ovarian cancer and evaluated its ability to suppress and abrogate tumor progression. In addition, we found...

article

Therapeutic potential of α,β‐thujone through metabolic reprogramming and caspase‐dependent apoptosis in ovarian cancer cells

Jin‐Young Lee, Hahyun Park, Whasun Lim, Gwonhwa Song

Journal of Cellular Physiology > 236 > 2 > 1545 - 1558

The therapeutic potential of α,β‐thujone, a functional compound found in many medicinal plants of the Cupressaceae, Asteraceae, and Lamiaceae families, has been demonstrated, including in inflammation and cancers. However, its pharmacological functions and mechanisms of action in ovarian cancer remain unclear. We investigated the anticancer properties of α,β‐thujone in ES2 and OV90 human ovarian cancer...

article

5,7‐Dimethoxyflavone induces apoptotic cell death in human endometriosis cell lines by activating the endoplasmic reticulum stress pathway

Wonhyoung Park, Min Young Park, Gwonhwa Song, Whasun Lim

Phytotherapy Research > 34 > 9 > 2275 - 2286

Endometriosis is a reproductive disorder characterized by the dislocation of endometrial tissues. Approximately 5–20% of women at their reproductive age are diagnosed with endometriosis, which causes chronic pain and infertility. Here, we demonstrated that the bioactive flavonoid, 5,7‐dimethoxyflavone (DMF), exhibited antiproliferative and apoptotic effects in VK2/E6E7 and End1/E6E7 cells which were...

article

Melatonin improves uterine‐conceptus interaction via regulation of SIRT1 during early pregnancy

Hyocheol Bae, Changwon Yang, Jin‐Young Lee, Sunwoo Park, more

Journal of Pineal Research > 69 > 2 > n/a - n/a

Melatonin has been shown to improve in vitro fertilization and offspring survival after bacterial infection, but its role in regulating maternal‐fetal communication during early pregnancy has not been investigated. Results of this study demonstrated expression of abundant melatonin receptors in conceptus and endometrium during early pregnancy. In gilts, expression of melatonin receptor 1A (MTNR1A...

article

The potential role of exosomes derived from ovarian cancer cells for diagnostic and therapeutic approaches

Changwon Yang, Hee Seung Kim, Gwonhwa Song, Whasun Lim

Journal of Cellular Physiology > 234 > 12 > 21493 - 21503

Most patients with ovarian cancer (OC) are diagnosed at the advanced stages due to the absence of appropriate early diagnostic markers. Thus, OC is a gynecological disease with a low‐survival rate. Exosomes are extracellular vesicles that are widely being considered as mediators for the noninvasive diagnosis of OC. Exosomes are expected to aid in the effective diagnosis of OC because they carry components,...

article

Quercetin augments apoptosis of canine osteosarcoma cells by disrupting mitochondria membrane potential and regulating PKB and MAPK signal transduction

Soomin Ryu, Sunwoo Park, Whasun Lim, Gwonhwa Song

Journal of Cellular Biochemistry > 120 > 10 > 17449 - 17458

Osteosarcoma is a mesenchymal malignant bone tumor accompanied by a high rate of lung metastasis and short survival in dogs. Although various therapies have been reported, the etiological mechanism of osteosarcoma remains undetermined and the development of novel therapeutic agents is warranted. In this study, we have reported the diverse functions of quercetin, one of the well‐known flavonoid, in...

article

Effects of luteolin on canine osteosarcoma: Suppression of cell proliferation and synergy with cisplatin

Soomin Ryu, Sunwoo Park, Whasun Lim, Gwonhwa Song

Journal of Cellular Physiology > 234 > 6 > 9504 - 9514

Canine osteosarcoma is characterized by aggressiveness, easy metastasis to the lungs, and high mortality after standard therapy. Luteolin is a flavonoid found in vegetables and fruits and has diverse functions. Elucidation of the biological mechanisms of luteolin on canine osteosarcoma will enhance the efficacy of chemotherapeutic agents in canine tumors. In this study, we examined the effects of...

article

Delphinidin induces antiproliferation and apoptosis of endometrial cells by regulating cytosolic calcium levels and mitochondrial membrane potential depolarization

Sunwoo Park, Whasun Lim, Gwonhwa Song

Journal of Cellular Biochemistry > 120 > 4 > 5072 - 5084

Endometriosis is a benign gynecological disease of women of reproductive ages, wherein endometrial cells grow ectopically, decreasing their quality of life due to chronic pelvic pain and severe dysmenorrhea. Although surgery and hormone therapies are gold standards for treating endometriosis, side effects are common and the recurrence rate is nearly 50%. Recent studies are exploring phytochemicals...

article

Ephrin A1 promotes proliferation of bovine endometrial cells with abundant expression of proliferating cell nuclear antigen and cyclin D1 changing the cell population at each stage of the cell cycle

Whasun Lim, Hyocheol Bae, Fuller W. Bazer, Gwonhwa Song

Journal of Cellular Physiology > 234 > 4 > 4864 - 4873

Ephrin A1 has a role in a variety of biological events, including cell proliferation, differentiation, migration, and angiogenesis. Ephrin A1 expression is abundant in trophoblasts and endometrial cells during the implantation period; however, its intracellular activities have not yet been reported in bovine endometrial (BEND) epithelial cells. The aim of this study was to identify the functional...

article

Silibinin‐induced endoplasmic reticulum stress and mitochondrial dysfunction suppress growth of endometriotic lesions

Jiyeon Ham, Jonggun Kim, Fuller W. Bazer, Whasun Lim, more

Journal of Cellular Physiology > 234 > 4 > 4327 - 4341

Silibinin is a flavonolignan extracted from milk thistle, which has been used for treating liver disorders, various cancers, and gynecological diseases. However, attempts for treating endometriosis with silibinin are lacking. In this study, we observed that silibinin exerts antiproliferative and apoptotic effects on human endometriotic cell lines VK2/E6E7 and End1/E6E7. We also identified that silibinin‐induced...

article

Chrysin leads to cell death in endometriosis by regulation of endoplasmic reticulum stress and cytosolic calcium level

Soomin Ryu, Fuller W. Bazer, Whasun Lim, Gwonhwa Song

Journal of Cellular Physiology > 234 > 3 > 2480 - 2490

Chrysin is a natural compound derived from honey, propolis, or passion flowers and has many functional roles, such as antiinflammatory and antiangiogenesis effects. Although endometriosis is a benign gynecological disease, there is a need to identify the pathology and develop a therapy for endometriosis. Elucidating the biological mechanism of chrysin on endometriosis will improve the understanding...

article

Carvacrol induces mitochondria‐mediated apoptosis via disruption of calcium homeostasis in human choriocarcinoma cells

Whasun Lim, Jiyeon Ham, Fuller W. Bazer, Gwonhwa Song

Journal of Cellular Physiology > 234 > 2 > 1803 - 1815

Carvacrol is a monoterpenoid phenol present in the oils of various plants including Origanum vulgare (oregano) or Origanum majorana (marjoram). For a long time, it has been used as spice in foods because of its antimicrobial properties. Additionally, it appears to have anticancer effects against some cancer but this has not been well studied. Therefore, we conducted various assays to confirm the effects...

article

Chrysophanol induces cell death and inhibits invasiveness via mitochondrial calcium overload in ovarian cancer cells

Whasun Lim, Yikyung An, Changwon Yang, Fuller W. Bazer, more

Journal of Cellular Biochemistry > 119 > 12 > 10216 - 10227

Chrysophanol is a phytochemical typically extracted from rhubarb. Similar to other extracts from rhubarb, chrysophanol possesses anticancer activity against diverse cancerous cells. However, the apoptotic effects of chrysophanol in ovarian cancer remain unknown. In the current study, we examined the antitumorigenic activity of chrysophanol in human epithelial ovarian cancer cells, such as ES2 and...

article

Trichlorfon inhibits proliferation and promotes apoptosis of porcine trophectoderm and uterine luminal epithelial cells

Whasun Lim, Yikyung An, Changwon Yang, Fuller W. Bazer, more

Environmental Pollution > 2018 > 242 > PA > 555-564

Trichlorfon is an organophosphate insecticide widely used in agriculture. Additionally, it is applied to pigs for control of endo- and ectoparasites. Previous studies have shown the effects of trichlorfon in pigs during late stages of gestation; however, little is known about its effects during early pregnancy, including implantation and placentation. We investigated whether trichlorfon affects proliferation...

article

Sideroxylin (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation

Sunwoo Park, Whasun Lim, Wonsik Jeong, Fuller W. Bazer, more

Journal of Cellular Physiology > 233 > 11 > 8597 - 8604

Sideroxylin is a C‐methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. However, the anticancer effects of sideroxylin and its intracellular signaling mechanisms have not yet been identified. Results of our study showed that sideroxylin decreased cell proliferation and increased apoptosis, causing DNA fragmentation, depolarization...

article

The O‐methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0/G1 cell phase arrest through PI3K/AKT and ERK1/2 inactivation

Sunwoo Park, Fuller W. Bazer, Whasun Lim, Gwonhwa Song

Journal of Cellular Biochemistry > 119 > 9 > 7377 - 7387

Formononetin is an isoflavone that is extracted from red clovers or soy. It has anti‐oxidant, anti‐proliferative, and anti‐tumor effects against cells in various diseases. Several cohort studies have indicated that phytoestrogen intake, including formononetin, could reduce the risk of various carcinogenesis. In fact, many case‐control studies have indicated the potential value of flavonoids as drug...

article

Myricetin treatment induces apoptosis in canine osteosarcoma cells by inducing DNA fragmentation, disrupting redox homeostasis, and mediating loss of mitochondrial membrane potential

Hahyun Park, Sunwoo Park, Fuller W. Bazer, Whasun Lim, more

Journal of Cellular Physiology > 233 > 9 > 7457 - 7466

Canine osteosarcoma is an aggressive primary bone tumor that shows metastasis to distal regions and is associated with a high mortality rate. However, the pathophysiological mechanisms of canine osteosarcoma are not well characterized. In addition, development of prognostic factors and novel therapeutic agents is necessary to efficiently treat osteosarcoma. Therefore, we studied the effects of myricetin,...

article

Cell-specific expression and signal transduction of C-C motif chemokine ligand 2 and atypical chemokine receptors in the porcine endometrium during early pregnancy

Whasun Lim, Hyocheol Bae, Fuller W. Bazer, Gwonhwa Song

Developmental & Comparative Immunology > 2018 > 81 > C > 312-323

Chemokines and atypical chemokine receptors (ACKRs; also known as chemokine decoy receptors) play an important role in reproductive immunology by recruiting leukocytes during early pregnancy. The aim of this study was to determine the expression of C-C motif chemokine ligand 2 (CCL2) and ACKRs in the endometrium during estrous cycle and early pregnancy, and to investigate the functional effects of...

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INFONA - science communication portal

Search results for: Gwonhwa Song

Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs

Fraxetin induces cell death in colon cancer cells via mitochondria dysfunction and enhances therapeutic effects in 5‐fluorouracil resistant cells

Osthole interacts with an ER‐mitochondria axis and facilitates tumor suppression in ovarian cancer

Therapeutic potential of α,β‐thujone through metabolic reprogramming and caspase‐dependent apoptosis in ovarian cancer cells

5,7‐Dimethoxyflavone induces apoptotic cell death in human endometriosis cell lines by activating the endoplasmic reticulum stress pathway

Melatonin improves uterine‐conceptus interaction via regulation of SIRT1 during early pregnancy

The potential role of exosomes derived from ovarian cancer cells for diagnostic and therapeutic approaches

Quercetin augments apoptosis of canine osteosarcoma cells by disrupting mitochondria membrane potential and regulating PKB and MAPK signal transduction

Effects of luteolin on canine osteosarcoma: Suppression of cell proliferation and synergy with cisplatin

Delphinidin induces antiproliferation and apoptosis of endometrial cells by regulating cytosolic calcium levels and mitochondrial membrane potential depolarization

Ephrin A1 promotes proliferation of bovine endometrial cells with abundant expression of proliferating cell nuclear antigen and cyclin D1 changing the cell population at each stage of the cell cycle

Silibinin‐induced endoplasmic reticulum stress and mitochondrial dysfunction suppress growth of endometriotic lesions

Chrysin leads to cell death in endometriosis by regulation of endoplasmic reticulum stress and cytosolic calcium level

Carvacrol induces mitochondria‐mediated apoptosis via disruption of calcium homeostasis in human choriocarcinoma cells

Chrysophanol induces cell death and inhibits invasiveness via mitochondrial calcium overload in ovarian cancer cells

Trichlorfon inhibits proliferation and promotes apoptosis of porcine trophectoderm and uterine luminal epithelial cells

Sideroxylin (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation

The O‐methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0/G1 cell phase arrest through PI3K/AKT and ERK1/2 inactivation

Myricetin treatment induces apoptosis in canine osteosarcoma cells by inducing DNA fragmentation, disrupting redox homeostasis, and mediating loss of mitochondrial membrane potential

Cell-specific expression and signal transduction of C-C motif chemokine ligand 2 and atypical chemokine receptors in the porcine endometrium during early pregnancy

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