Search results for: Xuechuan Hong

Items from 1 to 20 out of 41 results

article

Cover Picture: Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared‐II Imaging and Rapid Inactivation of Coronavirus (Angew. Chem. Int. Ed. 13/2023)

Yishen Liu, Meijia Gu, Qihang Ding, Zhiyun Zhang, more

Angewandte Chemie International Edition > 62 > 13 > n/a - n/a

The relationship between molecular configuration and charge transfer processes in near‐infrared‐II (NIR‐II) chromophores was studied, and subsequently instructed the engineering of an efficient NIR photosensitizer (PS), as reported by Wenbo Hu, Yuliang Xiao et al. in their Research Article (e202214875). The resulting NIR‐II PS not only enables NIR‐II image‐guided in vivo pulmonary coronavirus photo‐ablation...

article

Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared‐II Imaging and Rapid Inactivation of Coronavirus

Yishen Liu, Meijia Gu, Qihang Ding, Zhiyun Zhang, more

Angewandte Chemie International Edition > 62 > 13 > n/a - n/a

Despite significant effort, a majority of heavy‐atom‐free photosensitizers have short excitation wavelengths, thereby hampering their biomedical applications. Here, we present a facile approach for developing efficient near‐infrared (NIR) heavy‐atom‐free photosensitizers. Based on a series of thiopyrylium‐based NIR‐II (1000–1700 nm) dyads, we found that the star dyad HD with a sterically bulky and...

article

Titelbild: Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared‐II Imaging and Rapid Inactivation of Coronavirus (Angew. Chem. 13/2023)

Yishen Liu, Meijia Gu, Qihang Ding, Zhiyun Zhang, more

Angewandte Chemie > 135 > 13 > n/a - n/a

article

Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared‐II Imaging and Rapid Inactivation of Coronavirus

Yishen Liu, Meijia Gu, Qihang Ding, Zhiyun Zhang, more

Angewandte Chemie > 135 > 13 > n/a - n/a

article

Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer

Mingmin Ding, Hongbo Wang, Chunrong Qu, Fuchun Xu, more

Cancer Letters > 2018 > 432 > C > 47-55

Transient receptor potential canonical 6 (TRPC6) proteins form receptor-operated Ca²⁺-permeable channels, which have been thought to bring benefit to the treatment of diseases, including cancer. However, selective antagonists for TRPC channels are rare and none of them has been tested against gastric cancer. Compound 14a and analogs were synthesized by chemical elaboration of previously reported TRPC3/6/7...

article

New glowing dyes in vivo imaging with wavelengths beyond 1500 nm

Jing Yang, Xuechuan Hong

Science China Chemistry > 2019 > 62 > 1 > 7-8

article

A rapid and easy protein N‐terminal profiling strategy using (N‐Succinimidyloxycarbonylmethyl)tris(2,4,6‐trimethoxyphenyl)phosphonium bromide (TMPP) labeling and StageTip

Yanchang Li, Zhiqiang Wang, Wenjing Zhou, Kun Zhang, more

PROTEOMICS > 17 > 13-14 > n/a - n/a

Protein N‐terminal profiling is crucial when characterizing biological functions and provides proteomic evidences for genome reannotations. However, most of the current N‐terminal enrichment approaches involve multiple chemical derivatizations and chromatographic separation processes which are time consuming and can contribute to N‐terminal peptide losses. In this study, a fast, one‐step approach...

article

Imaging: Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR‐II Probe (Adv. Funct. Mater. 23/2017)

Kangquan Shou, Chunrong Qu, Yao Sun, Hao Chen, more

Advanced Functional Materials > 27 > 23 > n/a - n/a

In article number 1700995, Aixi Yu, Zhen Cheng, and co‐workers describe the creation of highly biocompatible, small‐organic‐molecules‐based nano‐vesicles with fluorescent emission in the NIR‐II window. This imaging agent can noninvasively and dynamically visualize many physiological and pathological conditions, and aid surgeons in performing accurate surgery. This approach will enable better diseases...

article

Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR‐II Probe

Kangquan Shou, Chunrong Qu, Yao Sun, Hao Chen, more

Advanced Functional Materials > 27 > 23 > n/a - n/a

Compared with imaging in the visible (400–650 nm) and near‐infrared window I (NIR‐I, 650–900 nm) regions, imaging in near‐infrared window II (NIR‐II, 1000–1700 nm) is a highly promising in vivo imaging modality with improved resolution and deeper tissue penetration. Here, a small molecule NIR‐II dye,5,5′‐(1H,5H‐benzo[1,2‐c:4,5‐c′] bis[1,2,5]thiadiazole)‐4,8‐diyl)bis(N,N‐bis(4‐(3‐((tert‐butyldimethylsilyl)oxy)propyl)phenyl)...

article

Hydroxyethyl Pachyman as a novel excipient for sustained-release matrix tablets

Xiaoju Zhou, Pengyu Wang, Jiong Wang, Zhi Liu, more

Carbohydrate Polymers > 2016 > 154 > C > 1-7

This paper addressed the application of hydroxyethyl pachyman (HEP) as a novel matrix for sustained – release tablets, using diclofenac sodium (DS) as a model drug. The studies showed the HEP tablets prepared by wet granulation had much slower drug release as compared to those prepared by direct compression. Meanwhile, increasing the percentage of HEP in the formulations caused a decrease in drug...

article

Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way

Ai-Jun Ding, Gui-Sheng Wu, Bin Tang, Xuechuan Hong, more

Molecular and Cellular Biochemistry > 2017 > 426 > 1-2 > 101-109

With the growth of aging population, there is increasing demand to develop strategy to improve the aging process and aging-related diseases. Benzimidazole and its derivatives are crucial heterocyclic backbone of many drugs and compounds with diverse therapeutic applications, including alleviation of aging-related diseases. Here, we investigate if the benzimidazole derivative n-butyl-[1H]-benzimidazol-2-amine...

article

Steroidal Ammonium Compounds as New Neuromuscular Blocking Agents

Zhigang Rao, Hao Hu, Jiazhi Tang, Zhiying Liu, more

Chemical Biology & Drug Design > 87 > 5 > 773 - 783

Neuromuscular blocking agents are widely used as an anesthesia auxiliary in surgery, which induce relaxation of skeletal muscles by blocking signal transmission at the neuromuscular junction. Many neuromuscular blocking agents s were developed over the past decades, but none of them fully meets the needs of the clinic by various reasons. In this study, a series of quaternary ammonium steroidal neuromuscular...

article

Identification and optimization of 2‐aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels

Yingmin Zhu, Yungang Lu, Chunrong Qu, Melissa Miller, more

British Journal of Pharmacology > 172 > 14 > 3495 - 3509

Background and PurposeTransient receptor potential canonical (TRPC) channels play important roles in a broad array of physiological functions and are involved in various diseases. However, due to a lack of potent subtype‐specific inhibitors the exact roles of TRPC channels in physiological and pathophysiological conditions have not been elucidated. Experimental ApproachUsing fluorescence membrane...

article

Total Synthesis of (±)‐8‐Oxo‐erythrinine, (±)‐8‐Oxo‐erythraline, and (±)‐Clivonine

Maomao He, Chunrong Qu, Bingbing Ding, Hao Chen, more

European Journal of Organic Chemistry > 2015 > 15 > 3240 - 3250

Total syntheses of the erythrina alkaloids (±)‐8‐oxo‐erythrinine and (±)‐8‐oxo‐erythraline have been developed, based on a substrate‐controlled intramolecular 6‐exo‐trig selective radical spirocyclization that establishes the quaternary center of the B‐rings. An improved total synthesis of (±)‐clivonine has also been reported, based on an intramolecular 6‐endo‐trig free‐radical cyclization of a highly...

article

Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes

Yao Sun, Xiaowei Ma, Kai Cheng, Biying Wu, more

Angewandte Chemie > 127 > 20 > 6079 - 6082

Small‐molecule‐based multimodal and multifunctional imaging probes play prominent roles in biomedical research and have high clinical translation ability. A novel multimodal imaging platform using base‐catalyzed double addition of thiols to a strained internal alkyne such as bicyclo[6.1.0]nonyne has been established in this study, thus allowing highly selective assembly of various functional units...

article

Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes

Yao Sun, Xiaowei Ma, Kai Cheng, Biying Wu, more

Angewandte Chemie International Edition > 54 > 20 > 5981 - 5984

article

3,16-Bisquaternary ammonium steroid derivatives as neuromuscular blocking agents: Synthesis and biological evaluation

Hao Hu, Zhigang Rao, Min Feng, Zhe Wu, more

Steroids > 2015 > 96 > C > 103-114

Neuromuscular blocking agents (NMBAs) are widely used in surgery to achieve skeleton muscles relaxation under light anesthesia status. In this work, we synthesized a series of 3,16-bisquaternary ammonium steroidal NMBAs. Among them, three compounds exhibited higher in vitro activities than the commenced drug rocuronium. In addition, structure–activity relationship was unveiled. We found that the intact...

article

Design, synthesis and pharmacological evaluation of novel N-(2-(1, 1-dimethyl-5, 7-dioxo-4, 6-diazaspiro[2.4]heptan-6-yl)ethyl) sulfonamide derivatives as potential anticonvulsant agents

Jinping Li, Jun Lou, Zhiming Wang, Ting Wang, more

European Journal of Medicinal Chemistry > 2015 > 92 > C > 370-376

A series of new N-(2-(1,1-dimethyl-5,7-dioxo-4,6-diazaspiro[2.4]heptan-6-yl)ethyl) sulfonamide derivatives (8a–i) and ethyl 2,2-dimethyl-1-(3-(2-(sulfonamido)ethyl)ureido) cyclopropanecarbox-ylate derivatives (9a–i) were designed, synthesized and evaluated for their anticonvulsant activities using maximal electroshock shock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure models in mice....

article

Studies Towards the Synthesis of Medermycin via Dötz Benzannulation

Chunrong Qu, Erqing Tang, Richard Loeppky, Zixin Deng, more

Chirality > 27 > 1 > 18 - 22

The C‐arylglycosides are available in enantiomerically pure form via the Dötz benzannulation reaction between Fischer alkenyl chromium carbene complexes and alkynes; it also could be converted to a precursor of medermycin by O‐carbamate directed ipsobromination and nitrile substitution in good overall yields. Chirality 27:18–22, 2015. © 2014 Wiley Periodicals, Inc.

article

Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors

Jun Lou, Xiaoyan Yang, Zhigang Rao, Wenwen Qi, more

European Journal of Medicinal Chemistry > 2014 > 83 > Complete > 466-473

A series of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives were prepared to evaluate their ability of inhibiting neuraminidase (NA) of influenza A virus. All the compounds were synthesized in good yields starting from aldehyde by using a suitable synthetic strategy, which showed moderate inhibitory activity against influenza A NA. Compound 6g exhibited the strongest inhibitory activity...

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INFONA - science communication portal

Search results for: Xuechuan Hong

Cover Picture: Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared‐II Imaging and Rapid Inactivation of Coronavirus (Angew. Chem. Int. Ed. 13/2023)

Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared‐II Imaging and Rapid Inactivation of Coronavirus

Titelbild: Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared‐II Imaging and Rapid Inactivation of Coronavirus (Angew. Chem. 13/2023)

Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared‐II Imaging and Rapid Inactivation of Coronavirus

Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer

New glowing dyes in vivo imaging with wavelengths beyond 1500 nm

A rapid and easy protein N‐terminal profiling strategy using (N‐Succinimidyloxycarbonylmethyl)tris(2,4,6‐trimethoxyphenyl)phosphonium bromide (TMPP) labeling and StageTip

Imaging: Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR‐II Probe (Adv. Funct. Mater. 23/2017)

Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR‐II Probe

Hydroxyethyl Pachyman as a novel excipient for sustained-release matrix tablets

Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way

Steroidal Ammonium Compounds as New Neuromuscular Blocking Agents

Identification and optimization of 2‐aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels

Total Synthesis of (±)‐8‐Oxo‐erythrinine, (±)‐8‐Oxo‐erythraline, and (±)‐Clivonine

Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes

Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes

3,16-Bisquaternary ammonium steroid derivatives as neuromuscular blocking agents: Synthesis and biological evaluation

Design, synthesis and pharmacological evaluation of novel N-(2-(1, 1-dimethyl-5, 7-dioxo-4, 6-diazaspiro[2.4]heptan-6-yl)ethyl) sulfonamide derivatives as potential anticonvulsant agents

Studies Towards the Synthesis of Medermycin via Dötz Benzannulation

Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors

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