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Objective: The aim of this study is to determine whether adenoviral inducible nitric oxide synthase (iNOS) gene transfer could inhibit intimal hyperplasia (IH) in porcine internal jugular veins interposed into the carotid artery circulation. Methods: Porcine internal jugular veins were transduced passively with 1 × 1011 particles of an adenoviral vector carrying either the human iNOS (AdiNOS) or β-galactosidase...