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We investigated the osteoconductivity and biocompatibility in vivo of a new hydroxyapatite–polymethylmethacrylate (HA–PMMA) composite developed for use as an implant material for cranioplasty, which is expected to have the good osteoconductivity of HA together with the strength and ease of handling of PMMA. The HA–PMMA composites were implanted in eight full-grown beagles and then 6, 12, 24 weeks...
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