Wyniki wyszukiwania dla: Anne Hamilton

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BRCA1 and BRCA2 carriers with breast, ovarian and prostate cancer demonstrate a different pattern of metastatic disease compared with non‐carriers: results from a rapid autopsy programme

Heather Thorne, Lisa Devereux, Jason Li, Kathryn Alsop, więcej

Aim To catalogue and compare the pattern of metastatic disease in germline BRCA1/2 pathogenic mutation carriers and non‐carriers with breast, ovarian and prostate cancer from a rapid autopsy programme. Methods and results The number of metastases in the major body systems and the proportion of participants with metastases were documented in 50 participants (19 germline mutation carriers). Analysis...

artykuł

Exploring the feasibility and utility of exome‐scale tumour sequencing in a clinical setting

Belinda Lee, Ben Tran, Arthur L. Hsu, Graham R. Taylor, więcej

Internal Medicine Journal > 48 > 7 > 786 - 794

Background Technology has progressed from single gene panel to large‐scale genomic sequencing. This is raising expectations from clinicians and patients alike. The utility and performance of this technology in a clinical setting needs to be evaluated. Aim This pilot study investigated the feasibility of using exome‐scale sequencing (ESS) to identify molecular drivers within cancers in real‐time...

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Stem cell therapy clinical research: A regulatory conundrum for academia

Anjali Nagpal, Chris Juttner, Monica Anne Hamilton-Bruce, Paul Rolan, więcej

Advanced Drug Delivery Reviews > 2017 > 122 > C > 105-114

The encouraging pace of discovery and development in the field of regenerative medicine holds tremendous potential for bringing therapies to the clinic that may offer meaningful benefit to patients, particularly in diseases with no or suboptimal therapeutic options. Academic researchers will continue to play a critical role in developing concepts and therapies, thus determining whether regenerative...

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Mainstreaming cancer genetics: A model integrating germline BRCA testing into routine ovarian cancer clinics

Maira Kentwell, Eryn Dow, Yoland Antill, C. David Wrede, więcej

Gynecologic Oncology > 2017 > 145 > 1 > 130-136

Owing to the rapid increase in clinical need, we aimed to implement and review the performance of a mainstreaming model of germline BRCA1/2 genetic testing in eligible women with high grade non-mucinous epithelial ovarian cancer via a Genetic Counselor embedded in the gynecology oncology clinic.The model implemented involved a specialized referral form, weekly genetics-lead multidisciplinary review...

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Genetic variation at 16q24.2 is associated with small vessel stroke

Matthew Traylor, Rainer Malik, Mike A. Nalls, Ioana Cotlarciuc, więcej

Annals of Neurology > 81 > 3 > 383 - 394

Objective Genome‐wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises one quarter of all ischemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological...

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Endovascular treatment for acute ischemic stroke: Experience in South Australia

Laura Ivete Rudaks, Idin Ahangar, Lizzie Dodd, Austin Graham Milton, więcej

International Journal of Stroke > 10 > 6 > E64 - E65

artykuł

Functional health literacy is significantly associated with risk factors for stroke in a population sample

Sarah Appleton, Sam Biermann, Anne Hamilton‐Bruce, Cynthia Piantadosi, więcej

International Journal of Stroke > 10 > 3 > E23 - E23

artykuł

Paternal Filicide in the Context of Domestic Violence: Challenges in Risk Assessment and Risk Management for Community and Justice Professionals

Peter G. Jaffe, Marcie Campbell, Laura Olszowy, Leslie Hazel Anne Hamilton

Child Abuse Review > 23 > 2 > 142 - 153

Paternal filicide in the context of domestic violence is a rare event that is often hard to predict and prevent. However, the results from current research with domestic homicide review committees suggest that warning signs may be overlooked by some professionals and agencies that do not foresee the direct harm to children. Even in cases where the dangers to adult victims were recognised, the potential...

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Responses to noxious stimuli in sedated mechanically ventilated adults

Mary Jo Grap, Cindy L. Munro, Paul A. Wetzel, Jessica M. Ketchum, więcej

Heart & Lung - The Journal of Acute and Critical Care > 2014 > 43 > 1 > 6-12

To determine the effect of sedation on physiologic responses and comfort before, during and after a noxious stimulus (endotracheal tube suctioning).The sample was a subset of a larger, longitudinal descriptive study, blood for endorphins and saliva for alpha-amylase were obtained before and after suctioning. Heart rate (HR), respiration rate (RR), oxygen saturation (SPO ₂ ), and arm and leg...

artykuł

Investigation of herb-drug interactions with ginkgo biloba in women receiving hormonal treatment for early breast cancer

Janette Vardy, Haryana M Dhillon, Stephen J Clarke, Inger Olesen, więcej

SpringerPlus > 2013 > 2 > 1 > 1-5

Women receiving treatment for breast cancer commonly ingest herbal medicines. Little is known about the potential for herb-drug interactions in this population. The aim of this study is to investigate the effect of ginkgo biloba co-administration on the pharmacokinetics of tamoxifen, anastrozole and letrozole. This was a prospective open-label cross-over study in 60 women with early stage breast cancer...

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Assessing Children’s Risk for Homicide in the Context of Domestic Violence

Leslie Hazel Anne Hamilton, Peter G. Jaffe, Marcie Campbell

Journal of Family Violence > 2013 > 28 > 2 > 179-189

Increasing evidence indicates that children are at risk of homicide in the context of domestic violence. Using a retrospective case analysis of 84 domestic homicide cases, this study sought to identify the unique factors that place a child at risk of homicide. Three groups of domestic homicide cases in which there were no children in the home (No Child in the Home, n = 44), a child was targeted (Child...

artykuł

Ventilator-associated Pneumonia: The Potential Critical Role of Emergency Medicine in Prevention

Mary Jo Grap, Cindy L. Munro, Takeshi Unoki, V. Anne Hamilton, więcej

Journal of Emergency Medicine > 2012 > 42 > 3 > 353-362

Delivery of critical care within a certain window of opportunity is paramount in many disease states, and providing the right care to these patients at the right time in the Emergency Department (ED) can significantly reduce mortality. However, aggressive treatment of these patients often requires endotracheal intubation and mechanical ventilation either in the pre-hospital or ED phase of care. Care...

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The role of the endotracheal tube cuff in microaspiration

V. Anne Hamilton, Mary Jo Grap

Heart & Lung - The Journal of Acute and Critical Care > 2012 > 41 > 2 > 167-172

The cuff of the endotracheal tube (ETT) is designed to provide a seal within the airway, allowing airflow through the ETT but preventing passage of air or fluids around the ETT. Deliberate or inadvertent movement of the ETT may affect cuff pressure or shift folds in the cuff, mobilizing pooled secretions. When this seal is compromised, microaspirations contaminated with gastric contents or bacterially...

artykuł

Association of the phosphodiesterase 4D (PDE4D) gene and cardioembolic stroke in an Australian cohort

Austin G. Milton, Verna M. Aykanat, M. Anne Hamilton‐Bruce, Mark Nezic, więcej

International Journal of Stroke > 6 > 6 > 480 - 486

Background Large‐scale epidemiological studies support an important role for susceptibility genes in the pathogenesis of ischemic stroke, with phosphodiesterase 4D identified as the first gene predisposing to ischemic stroke. Several single nucleotide polymorphisms within the phosphodiesterase 4D gene have been implicated in the pathogenesis of stroke. Aim Undertake a multivariate analysis...

artykuł

Early, single chlorhexidine application reduces ventilator-associated pneumonia in trauma patients

Mary Jo Grap, Cindy L. Munro, V. Anne Hamilton, R.K. Elswick, więcej

Heart & Lung - The Journal of Acute and Critical Care > 2011 > 40 > 5 > e115-e122

Ventilator-associated pneumonia (VAP) is an important complication of mechanical ventilation and is particularly common in trauma, burn, and surgical patients. Interventions that kill bacteria in the oropharynx reduce the pool of viable organisms available for translocation to the lung and thereby lessen the likelihood of developing VAP. Repeated administration of chlorhexidine (CHX) to the mouth...

artykuł

Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study

Ticiana B. Leal, Scot C. Remick, Chris H. Takimoto, Ramesh K. Ramanathan, więcej

Cancer Chemotherapy and Pharmacology > 2011 > 68 > 6 > 1439-1447

Purpose To determine the toxicities, pharmacokinetics, pharmacodynamics, and maximum tolerated dose of bortezomib in patients with renal impairment and to develop dosing guidelines for such a patient population. Patients and Methods Sixty-two adult cancer patients received intravenous bortezomib at 0.7–1.5 mg/m² on days 1, 4, 8, and 11 every 3 weeks. Patients were stratified by 24-h creatinine clearance...

artykuł

Cetuximab is Associated With Excessive Toxicity When Combined With Bevacizumab Plus mFOLFOX6 in Metastatic Colorectal Carcinoma

Allyson J. Ocean, Blase Polite, Paul Christos, Lisa Horvath, więcej

Clinical Colorectal Cancer > 2010 > 9 > 5 > 290-296

The bevacizumab-cetuximab combination has shown promising activity in chemotherapy-refractory metastatic colorectal cancer (mCRC). We sought to determine the safety and efficacy of cetuximab added to bevacizumab plus standard mFOLFOX6 (modified 5-fluorouracil [5-FU]/leucovorin/oxaliplatin) as first-line therapy for mCRC. Sixty-six patients received cetuximab (400 mg/m ² loading dose, then...

artykuł

High Notch1 protein expression is an early event in breast cancer development and is associated with the HER‐2 molecular subtype

Sarah J Zardawi, Ibrahim Zardawi, Catriona M McNeil, Ewan K A Millar, więcej

Histopathology > 56 > 3 > 286 - 296

Zardawi S J, Zardawi I, McNeil C M, Millar E K A, McLeod D, Morey A L, Crea P, Murphy N C, Pinese M, Lopez‐Knowles E, Oakes S R, Ormandy C J, Qiu M R, Hamilton A, Spillane A, Soon Lee C, Sutherland R L, Musgrove E A & O’Toole S A (2010) Histopathology56, 286–296 High Notch1 protein expression is an early event in breast cancer development and is associated with the HER‐2 molecular subtype Aims: ...

artykuł

Results of a multicenter, randomized, double‐blind phase 2/3 study of lenalidomide in the treatment of pretreated relapsed or refractory metastatic malignant melanoma

Tim Eisen, Uwe Trefzer, Anne Hamilton, Peter Hersey, więcej

Cancer > 116 > 1 > 146 - 154

BACKGROUND:The results of an international, multicenter, randomized, double‐blind, controlled study assessing the efficacy and safety of lenalidomide treatment in patients with refractory stage IV metastatic malignant melanoma are reported. METHODS:The study compared treatment with lenalidomide (25 mg/d on Days 1‐21 of a 28‐day cycle) to placebo in 306 patients with metastatic malignant melanoma...

artykuł

Phase I study of bryostatin 1, a protein kinase C modulator, preceding cisplatin in patients with refractory non-hematologic tumors

Anna C. Pavlick, Jennifer Wu, John Roberts, Mark A. Rosenthal, więcej

Cancer Chemotherapy and Pharmacology > 2009 > 64 > 4 > 803-810

Purpose Preclinical data suggested that bryostatin-1 (bryo) could potentiate the cytotoxicity of cisplatin when given prior to this drug. We designed a phase I study to achieve tolerable doses and schedules of bryo and cisplatin in combination and in this sequence. Methods Patients with non-hematologic malignancies received bryo followed by cisplatin in several schedules. Bryo was given as an 1...

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