Search results for: Thomas N. Ferraro

Items from 1 to 20 out of 30 results

article

Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations

Remi Stevelink, Jurjen J. Luykx, Bochao D. Lin, Costin Leu, more

Epilepsia > 62 > 7 > 1518 - 1527

Objective Paroxysmal epileptiform abnormalities on electroencephalography (EEG) are the hallmark of epilepsies, but it is uncertain to what extent epilepsy and background EEG oscillations share neurobiological underpinnings. Here, we aimed to assess the genetic correlation between epilepsy and background EEG oscillations. Methods Confounding factors, including the heterogeneous etiology of epilepsies...

article

Investigation of long interspersed element‐1 retrotransposons as potential risk factors for idiopathic temporal lobe epilepsy

Glenn A. Doyle, Benjamin C. Reiner, Richard C. Crist, Aditya M. Rao, more

Epilepsia > 62 > 6 > 1329 - 1342

Objective To determine if long interspersed element‐1 (L1) retrotransposons convey risk for idiopathic temporal lobe epilepsy (TLE). Methods Surgically resected temporal cortex from individuals with TLE (N = 33) and postmortem temporal cortex from individuals with no known neurological disease (N = 33) were analyzed for L1 content by Restriction Enzyme Based Enriched L1Hs sequencing (REBELseq)...

article

The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy

Wolfgang Löscher, Russell J. Ferland, Thomas N. Ferraro

Epilepsy & Behavior > 2017 > 73 > C > 214-235

It is becoming increasingly clear that the genetic background of mice and rats, even in inbred strains, can have a profound influence on measures of seizure susceptibility and epilepsy. These differences can be capitalized upon through genetic mapping studies to reveal genes important for seizures and epilepsy. However, strain background and particularly mixed genetic backgrounds of transgenic animals...

article

Case-control association study of WLS variants in opioid and cocaine addicted populations

Richard C. Crist, Lisa M. Ambrose-Lanci, Angela Zeng, Cindy Yuan, more

Psychiatry Research > 2013 > 208 > 1 > 62-66

The opioid receptor family is involved in the development and maintenance of drug addiction. The mu-opioid receptor (MOR) mediates the rewarding effects of multiple drugs, including opiates and cocaine. A number of proteins interact with MOR, potentially modulating MOR function and altering the physiological consequences of drug use. These mu-opioid receptor interacting proteins (MORIPs) are potential...

article

Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta‐analysis

Toni‐Kim Clarke, Paul J. Bloch, Lisa M. Ambrose‐Lanci, Thomas N. Ferraro, more

Addiction Biology > 18 > 4 > 702 - 708

Genetic research on cocaine dependence (CD) may help clarify our understanding of the disorder as well as provide insights for effective treatment. As endocannabinoid signaling and dopamine neurotransmission have been shown to be involved in drug reward, genes related to these systems are plausible candidates for susceptibility to CD. The cannabinoid receptor 1 protein regulates both the endocannabinoid...

article

Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine

Toni-Kim Clarke, Richard C. Crist, Kyle M. Kampman, Charles A. Dackis, more

Neuroscience Letters > 2013 > 542 > Complete > 71-75

The μ-opioid receptor (MOR) binds exogenous and endogenous opioids and is known to mediate the rewarding effects of drugs of abuse. Numerous genetic studies have sought to identify common genetic variation in the gene encoding MOR (OPRM1) that affects risk for drug addiction. The purpose of this study was to examine the contribution of rare coding variants in OPRM1 to the risk for addiction. Rare...

article

Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike‐wave discharges in DBA/2 mice

Thomas Bessaïh, Esther Garcia de Yebenes, Kyle Kirkland, Michael J. Higley, more

Epilepsia > 53 > 8 > 1429 - 1435

Purpose: Most common forms of human epilepsy result from a complex combination of polygenetic and environmental factors. Quantitative trait locus (QTL) mapping is a first step toward the nonbiased discovery of epilepsy‐related candidate genes. QTL studies of susceptibility to induced seizures in mouse strains have consistently converged on a distal region of chromosome 1 as a major phenotypic determinant;...

article

Strategies for studying the epilepsy genome

Thomas N. Ferraro, Jose M. Serratosa, Deb K. Pal, Guy A. Rouleau, more

Epilepsia > 51 > s5 > 58 - 58

Most human epilepsies are multifactorial, resulting from combined effects of genes and environment. The large number of genes whose variation and/or mutation influences the development and progression of epilepsy are only now beginning to be identified. Advanced methods of genetic analysis promise to facilitate understanding of pathogenesis and establishment of new effective treatments. For an expanded...

article

Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder

Paul J. Bloch, Andrew E. Weller, Glenn A. Doyle, Thomas N. Ferraro, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2010 > 34 > 8 > 1515-1519

Linkage studies in bipolar disorder (BPD) suggest that a susceptibility locus exists on chromosome 18p11. The myo-inositol monophosphatase 2 gene (IMPA2) maps to this genomic region. Myo-inositol monophosphatase dephosphorylates inositol monophosphate, regenerating free inositol. Lithium, a common treatment for BPD, has been shown to inhibit IMPA2 activity and decrease levels of inositol. It is hypothesized...

article

Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure‐susceptible DBA/2 mice

Mikhail Inyushin, Lilia Y. Kucheryavykh, Yuriy V. Kucheryavykh, Colin G. Nichols, more

Epilepsia > 51 > 9 > 1707 - 1713

Purpose: KCNJ10 encodes subunits of inward rectifying potassium (Kir) channel Kir4.1 found predominantly in glial cells within the brain. Genetic inactivation of these channels in glia impairs extracellular K⁺ and glutamate clearance and produces a seizure phenotype. In both mice and humans, polymorphisms and mutations in the KCNJ10 gene have been associated with seizure susceptibility. The purpose...

article

Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence

Falk W. Lohoff, Paul J. Bloch, Rachel Hodge, Aleksandra H. Nall, more

Neuroscience Letters > 2010 > 473 > 2 > 87-91

Genetic research on cocaine dependence (CD) may help clarify our understanding of the disorder as well as provide novel insights for effective treatment. Since dopamine neurotransmission has been shown to be involved in drug reward, related genes are plausible candidates for susceptibility to CD. The dopamine receptor D ₂ (DRD2) protein and dopamine transporter (DAT1) protein play regulatory...

article

Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence

Falk W. Lohoff, Paul J. Bloch, Thomas N. Ferraro, Wade H. Berrettini, more

Neuroscience Letters > 2009 > 453 > 3 > 199-203

Cocaine-induced neuroplasticity changes in the mesocorticolimbic dopamine systems are thought to be involved in the pathophysiology of cocaine dependence. Since neurotrophic factors have been observed to prevent/reverse and mimic cocaine-induced neurobiological changes in the brain, related genes are plausible candidates for susceptibility to cocaine dependence. The novel conserved dopamine neurotrophic...

article

Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence

Falk W. Lohoff, Paul J. Bloch, Andrew E. Weller, Aleksandra H. Nall, more

Neuroscience Letters > 2008 > 440 > 3 > 280-283

Dopaminergic brain systems have been implicated to play a major role in drug reward, thus making genes involved in these circuits plausible candidates for susceptibility to substance use disorders. The cocaine- and amphetamine-regulated transcript peptide (CARTPT) is involved in reward and feeding behavior and has functional characteristics of an endogenous psychostimulant. In this study we tested...

article

Association between variation in the vesicular monoamine transporter 1 gene on chromosome 8p and anxiety-related personality traits

Falk W. Lohoff, Marion Lautenschlager, Johannes Mohr, Thomas N. Ferraro, more

Neuroscience Letters > 2008 > 434 > 1 > 41-45

Vesicular monoamine transporters are involved in the presynaptic packaging of norepinephrine, dopamine and serotonin into storage vesicles. The vesicles release their content upon arrival of an action potential into the synaptic cleft. Dysregulation of monoaminergic neurotransmission has been long postulated to play a relevant role in the etiology of neuropsychiatric disorders. The gene encoding the...

article

Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder

Falk W. Lohoff, Andrew E. Weller, Paul J. Bloch, Aleksandra H. Nall, more

Journal of Neural Transmission > 2008 > 115 > 9 > 1339-1345

Linkage studies in bipolar disorder (BPD) suggest that a susceptibility locus exists on chromosome 18p11. The vesicle-associated membrane protein-associated protein A (VAPA) gene maps to this region. VAPA interacts with presynaptic proteins and is necessary for vesicular neurotransmission. Dysregulation of synaptic neurotransmission might contribute to the pathophysiology of BPD. In this study, we...

article

Novel De Novo Mutation of a Conserved SCN1A Amino-Acid Residue (R1596)

Dennis J. Dlugos, Thomas N. Ferraro, Russell J. Buono

Pediatric Neurology > 2007 > 37 > 4 > 303-305

We report on the case of a 6-year-old boy with epilepsy involving febrile seizures and unprovoked generalized tonic clonic seizures. Genetic testing revealed a novel de novo mutation in the SCN1A gene (C>T 4786, R1596C). The epilepsy phenotype is within the spectrum of generalized epilepsy with febrile seizures plus. However, de novo mutations are more commonly reported in cases of severe myoclonic...

article

Identification of five mouse μ-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon

Glenn A. Doyle, X. Rebecca Sheng, Sharon S.J. Lin, Danielle M. Press, more

Gene > 2007 > 395 > 1-2 > 98-107

The mouse μ-opioid receptor gene, Oprm1, currently contains 18 recognized alternatively spliced exons [Doyle, G.A., Sheng, X.R., Lin, S.S.J., Press, D.M., Grice, D.E., Buono, R.J., Ferraro, T.N., Berrettini, W.H., 2007. Identification of three mouse μ-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. Gene 388 (1–2) 135–147, in press (doi:10...

article

Identification of three mouse μ-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon

Glenn A. Doyle, X. Rebecca Sheng, Sharon S.J. Lin, Danielle M. Press, more

Gene > 2007 > 388 > 1-2 > 135-147

The mouse μ-opioid receptor gene, Oprm1, is recognized currently to contain 17 alternatively spliced exons that generate 24 splice variants encoding at least 11 morphine-binding isoforms of the receptor. Here, we identify three new MOR splice variants that contain a previously undescribed exon, exon 18, and provide evidence that they are expressed in two mouse strains. The transcripts containing the...

article

Identification and functional significance of polymorphisms in the μ-opioid receptor gene (Oprm) promoter of C57BL/6 and DBA/2 mice

Glenn A. Doyle, X. Rebecca Sheng, Candice L. Schwebel, Thomas N. Ferraro, more

Neuroscience Research > 2006 > 55 > 3 > 244-254

C57BL/6J and DBA/2J mice demonstrate differences in morphine preference when tested in a two-bottle choice paradigm. Quantitative trait loci (QTL) mapping suggested the proximal region of chromosome 10 was responsible for 41% of the observed genetic variance. The μ-opioid receptor (MOR) gene (Oprm) maps to this region and is a prime candidate for explaining the QTL. We hypothesized that variations...

article

Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependence

John P. Dahl, Glenn A. Doyle, David W. Oslin, Russell J. Buono, more

Journal of Psychiatric Research > 2005 > 39 > 5 > 475-479

While the physiological mechanisms that contribute to the development of alcohol dependence remain unclear, a number of recent studies have indicated a role for the corticotropin releasing hormone receptor 1 (CRHR1) in modulating the response of the central nervous system to ethanol. Based on these data, the present study aims to identify associations between variations in the CRHR1 gene and alcohol...

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Thomas N. Ferraro

Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations

Investigation of long interspersed element‐1 retrotransposons as potential risk factors for idiopathic temporal lobe epilepsy

The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy

Case-control association study of WLS variants in opioid and cocaine addicted populations

Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta‐analysis

Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine

Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike‐wave discharges in DBA/2 mice

Strategies for studying the epilepsy genome

Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder

Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure‐susceptible DBA/2 mice

Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence

Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence

Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence

Association between variation in the vesicular monoamine transporter 1 gene on chromosome 8p and anxiety-related personality traits

Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder

Novel De Novo Mutation of a Conserved SCN1A Amino-Acid Residue (R1596)

Identification of five mouse μ-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon

Identification of three mouse μ-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon

Identification and functional significance of polymorphisms in the μ-opioid receptor gene (Oprm) promoter of C57BL/6 and DBA/2 mice

Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependence

Filter options

Publication date

Content availability

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Thomas N. Ferraro

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options