Search results for: Morten Overgaard

Items from 1 to 20 out of 42 results

article

Win‐loss parameters for right‐censored event data, with application to recurrent events

Erik T. Parner, Morten Overgaard

Statistics in Medicine > 42 > 30 > 5723 - 5735

The win ratio has become a popular method for comparing multiple event data between two groups in clinical cohort studies. The win ratio compares the event data in prioritized order, where the first prioritized event is death and a typical example for the second prioritized event is hospitalization. Literature is sparse on inference for win and loss parameters, including the win ratio, for censored...

article

Task requirements affect the neural correlates of consciousness

Lau M. Andersen, Mikkel C. Vinding, Kristian Sandberg, Morten Overgaard

European Journal of Neuroscience > 56 > 10 > 5810 - 5822

In the search for the neural correlates of consciousness, it is often assumed that there is a stable set within the relevant sensory modality. Within the visual modality, the debate has centred upon whether frontal or occipital activations are the best predictors of perceptual awareness. Although not accepted by all as definitive evidence, no‐report and decoding studies have indicated that occipital...

article

No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients

Ida Kuhlmann, Rasmus Hjelmar Petersen, Morten Overgaard, Kenn Dornonville de la Cour, more

Basic & Clinical Pharmacology & Toxicology > 130 > 1 > 93 - 102

We investigated the impact of genetic variants in OCT1 (SLC22A1) on morphine, morphine‐3‐glucuronide (M3G) and morphine‐6‐glucuronide (M6G) pharmacokinetics in adult patients scheduled for major surgery. Blood samples were taken before and 5, 10, 15, 30, 45, 60 and 90 min after a bolus of morphine (0.15 mg/kg). Patients were genotyped for the genetic variants (rs12208357, rs34059508, rs72552763 and...

article

On the assumption of independent right censoring

Morten Overgaard, Stefan Nygaard Hansen

Scandinavian Journal of Statistics > 48 > 4 > 1234 - 1255

Various assumptions on a right‐censoring mechanism to ensure consistency of the Kaplan–Meier and Aalen–Johansen estimators in a competing risks setting are studied. Specifically, eight different assumptions are seen to fall in two categories: a weaker identifiability assumption, which is the weakest possible assumption in a precise sense, and a stronger representativity assumption which ensures the...

article

Pupillary reactivity to alcohol cues as a predictive biomarker of alcohol relapse following treatment in a pilot study

Timo L. Kvamme, Mads Uffe Pedersen, Morten Overgaard, Kristine Rømer Thomsen, more

Psychopharmacology > 2019 > 236 > 4 > 1233-1243

Rationale Identifying the predictors of relapse in detoxified alcohol-dependent patients is crucial for effective surveillance procedures and the optimization of treatment. Physiological measures such as functional MRI activity and heart rate variability have been shown as potential markers of relapse prediction. Objectives Our aim was to assess differential pupillary reactions to alcohol-related...

article

Estimating the variance in a pseudo‐observation scheme with competing risks

Morten Overgaard, Erik Thorlund Parner, Jan Pedersen

Scandinavian Journal of Statistics > 45 > 4 > 923 - 940

The Huber–White sandwich variance estimator of the variance of estimates from a regression using jack‐knife pseudo‐observations from the Aalen–Johansen estimator in a competing risks situation is known to be biased. In this paper, an expression of the asymptotic bias of the Huber–White variance estimator is found, and the Huber–White variance estimator is seen to be biased upwards. An alternative...

article

A Multi‐Factor Account of Degrees of Awareness

Peter Fazekas, Morten Overgaard

Cognitive Science > 42 > 6 > 1833 - 1859

In this paper we argue that awareness comes in degrees, and we propose a novel multi‐factor account that spans both subjective experiences and perceptual representations. At the subjective level, we argue that conscious experiences can be degraded by being fragmented, less salient, too generic, or flash‐like. At the representational level, we identify corresponding features of perceptual representations—their...

article

Multiple Factors and Multiple Mechanisms Determine the Quality of Conscious Experiences: A Reply to Anzulewicz and Wierzchoń

Peter Fazekas, Morten Overgaard

Cognitive Science > 42 > 6 > 2101 - 2103

In this Letter to the Editor, we seize the opportunity to respond to the recent comments by Anzulewicz and Wierzchoń, and further clarify and extend the scope of our original paper. We re‐emphasize that conscious experiences come in degrees, and that there are several factors that determine this degree. Endorsing the suggestions of Anzulewicz and Wierzchoń, we discuss that besides low‐level attentional...

article

Early visual processing allows for selective behavior, shifts of attention, and conscious visual experience in spite of masking

Sébastien M. Crouzet, Lyudmyla Y. Kovalenko, Simon Hviid del Pin, Morten Overgaard, more

Consciousness and Cognition > 2017 > 54 > C > 89-100

Object-substitution masking (OSM) occurs when a briefly displayed target in a search array is surrounded by a mask, which remains onscreen after the target has disappeared. It has been suggested that OSM results from a specific interference with reentrant visual processing, while the initial feedforward processing is left intact. Here, we tested the prediction that the fastest saccadic responses towards...

article

Estimating a population cumulative incidence under calendar time trends

Stefan N. Hansen, Morten Overgaard, Per K. Andersen, Erik T. Parner

BMC Medical Research Methodology > 2017 > 17 > 1 > 1-10

Background The risk of a disease or psychiatric disorder is frequently measured by the age-specific cumulative incidence. Cumulative incidence estimates are often derived in cohort studies with individuals recruited over calendar time and with the end of follow-up governed by a specific date. It is common practice to apply the Kaplan–Meier or Aalen–Johansen estimator to the total sample and report...

article

Risk of epilepsy and autism in full and half siblings—A population‐based cohort study

Jakob Christensen, Morten Overgaard, Erik T. Parner, Mogens Vestergaard, more

Epilepsia > 57 > 12 > 2011 - 2018

Objective Epilepsy and autism spectrum disorder (ASD) often occur together in the same individual. However, it remains unknown whether siblings of children with ASD have an increased risk of epilepsy and vice versa. This study determines the risk of ASD and epilepsy among younger siblings of children with ASD and epilepsy. Design The study included all children born in Denmark between January 1,...

article

Multidimensional Models of Degrees and Levels of Consciousness

Peter Fazekas, Morten Overgaard

Trends in Cognitive Sciences > 2016 > 20 > 10 > 715-716

article

Can No-Report Paradigms Extract True Correlates of Consciousness?

Morten Overgaard, Peter Fazekas

Trends in Cognitive Sciences > 2016 > 20 > 4 > 241-242

article

An integrative view on consciousness and introspection

Morten Overgaard, Jesper Mogensen

Review of Philosophy and Psychology > 2017 > 8 > 1 > 129-141

The relation between first and higher order mental states is currently unknown. In particular, the relation between conscious experience and introspection is difficult as the same methods are used to investigate them. In order to make progress in the scientific understanding of consciousness, introspection or both, it is fundamental to understand whether their relation is serial (conscious experience...

chapter

How Unconscious is Subliminal Perception?

Morten Overgaard, Bert Timmermans

Handbook of Phenomenology and Cognitive Science > 501-518

Ever since the concept of the “unconscious” defragmented one of the last nuclei of certitude in the western world, one of the great mysteries that common knowledge has come to associate with psychology is the idea that much of what goes on in our lives occurs outside of awareness. In other words, what we experience is but the tip of the iceberg: massive amounts of information are processed, have an...

article

Reconciling current approaches to blindsight

Morten Overgaard, Jesper Mogensen

Consciousness and Cognition > 2015 > 32 > Complete > 33-40

After decades of research, blindsight is still a mysterious and controversial topic in consciousness research. Currently, many researchers tend to think of it as an ideal phenomenon to investigate neural correlates of consciousness, whereas others believe that blindsight is in fact a kind of degraded vision rather than “truly blind”. This article considers both perspectives and finds that both have...

article

Distinct MEG correlates of conscious experience, perceptual reversals and stabilization during binocular rivalry

Kristian Sandberg, Gareth Robert Barnes, Bahador Bahrami, Ryota Kanai, more

NeuroImage > 2014 > 100 > C > 161-175

During binocular rivalry, visual perception alternates spontaneously between two different monocular images. Such perceptual reversals are slowed or halted if stimuli are presented intermittently with inter-stimulus intervals larger than ~400ms — a phenomenon called stabilization. Often, the neural correlates of reversal and stabilization are studied separately, and both phenomena in turn are studied...

article

Experience of action depends on intention, not body movement: An experiment on memory for mens rea

Mads Jensen, Eleonora Vagnoni, Morten Overgaard, Patrick Haggard

Neuropsychologia > 2014 > 55 > Complete > 122-127

How do we know whether our own actions were voluntary or involuntary? Intentional theories of sense of agency suggest that we consciously perceive the intentions that accompany our actions, but reconstructive theories suggest that we perceive our actions only through the body movements and other effects that they produce. Intentions would then be mere confabulations, and not bona fide experiences...

article

Uncertainty and confidence from the triple-network perspective: Voxel-based meta-analyses

Thomas P. White, Nina Helkjær Engen, Susan Sørensen, Morten Overgaard, more

Brain and Cognition > 2014 > 85 > Complete > 191-200

Our subjective confidence about particular events is related to but independent from the objective certainty of the stimuli we encounter. Surprisingly, previous investigations of the neurophysiological correlates of confidence and uncertainty have largely been carried out separately. After systematically reviewing the blood oxygenation-level dependent functional magnetic resonance imaging (BOLD fMRI)...

article

Distinct electrophysiological potentials for intention in action and prior intention for action

Mikkel C. Vinding, Mads Jensen, Morten Overgaard

Cortex > 2014 > 50 > Complete > 86-99

The role of conscious intention in relation to motoric movements has become a major topic of investigation in neuroscience. Traditionally, reports of conscious intention have been compared to various features of the readiness-potential (RP) – an electrophysiological signal that appears before voluntary movements. Experiments, however, tend to study intentions in immediate relation to movements (proximal...

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INFONA - science communication portal

Search results for: Morten Overgaard

Win‐loss parameters for right‐censored event data, with application to recurrent events

Task requirements affect the neural correlates of consciousness

No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients

On the assumption of independent right censoring

Pupillary reactivity to alcohol cues as a predictive biomarker of alcohol relapse following treatment in a pilot study

Estimating the variance in a pseudo‐observation scheme with competing risks

A Multi‐Factor Account of Degrees of Awareness

Multiple Factors and Multiple Mechanisms Determine the Quality of Conscious Experiences: A Reply to Anzulewicz and Wierzchoń

Early visual processing allows for selective behavior, shifts of attention, and conscious visual experience in spite of masking

Estimating a population cumulative incidence under calendar time trends

Risk of epilepsy and autism in full and half siblings—A population‐based cohort study

Multidimensional Models of Degrees and Levels of Consciousness

Can No-Report Paradigms Extract True Correlates of Consciousness?

An integrative view on consciousness and introspection

How Unconscious is Subliminal Perception?

Reconciling current approaches to blindsight

Distinct MEG correlates of conscious experience, perceptual reversals and stabilization during binocular rivalry

Experience of action depends on intention, not body movement: An experiment on memory for mens rea

Uncertainty and confidence from the triple-network perspective: Voxel-based meta-analyses

Distinct electrophysiological potentials for intention in action and prior intention for action

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