Search results for: Jae Sung Kim

Items from 1 to 20 out of 175 results

article

Swelling Behaviors of Natural Rubber/Solvent Systems Based on the Extended Modified Double Lattice Model

Sung Jin Pai, Eung Jun Kang, Won Min Ahn, Jae Sung Kim, more

Macromolecular Theory and Simulations > 33 > 4 > n/a - n/a

Swelling experiments are conducted on nonfiller natural rubber using four solvents (toluene, cyclohexane, tetrahydrofuran (THF), and methylethylketone (MEK)) over temperatures from 10 to 70 °C. Toluene, cyclohexane, and THF, classified as effective solvents, show swelling ratios between 3 and 7, influenced by the crosslink density of the rubber. MEK, however, has a lower ratio of 1.5 to 2. Temperature...

article

25‐Hydroxycholesterol induces odontoclastic differentiation through RANK–RANKL upregulation and NF‐κB activation in odontoblast‐like MDPC‐23 cells: An in vitro study

HyangI Lim, Ji‐Su Oh, Kyeong‐Rok Kang, Jeong‐Yeon Seo, more

International Endodontic Journal > 56 > 4 > 432 - 446

Aim The physiological effects and cellular mechanism of 25‐hydroxycholesterol (25‐HC), which is an oxysterol synthesized from cholesterol by cholesterol‐25‐hydroxylase (CH25H) expressed under inflammatory conditions, are still largely unknown during odontoclastogenesis. This study aimed to evaluate 25‐HC‐induced odontoclastogenesis and its cellular mechanisms in odontoblast‐like MDPC‐23 cells. ...

article

TCTP overexpression reverses age‐associated telomere attrition by upregulating telomerase activity in mouse oocytes

Hyuk‐Joon Jeon, Minsung Kang, Jae‐Sung Kim, Jeong Su Oh

Journal of Cellular Physiology > 237 > 1 > 833 - 845

A prolonged time span between ovulation and fertilization can cause postovulatory aging of oocytes, which impairs oocyte quality and subsequent embryo development. Telomere attrition has long been considered as the primary hallmark of aging or the cause of age‐associated diseases. However, the status of telomere and its regulation during postovulatory oocyte aging are poorly understood. Here we found...

article

Melatonin protects mouse oocytes from DNA damage by enhancing nonhomologous end‐joining repair

Jiyeon Leem, Guang‐Yu Bai, Jae‐Sung Kim, Jeong Su Oh

Journal of Pineal Research > 67 > 4 > n/a - n/a

Mammalian oocytes remain arrested at the first prophase of meiosis in ovarian follicles for an extended period. During this protracted arrest, oocytes are remarkably susceptible to the accumulation of DNA damage. Melatonin (N‐acetyl‐5‐methoxytryptamine), a hormone secreted by the pineal gland, has diverse effects on various physiological processes. However, the effect of melatonin on DNA damage response...

article

Possibility of Interchanging Patients for Beam-Matched Linear Accelerators from the Same Vendor

Seonghee Kang, Jin-Beom Chung, Keun-Yong Eom, Changhoon Song, more

Journal of the Korean Physical Society > 2019 > 75 > 8 > 628-635

The purpose of this study is to investigate the possibility of interchanging patients on beam-matched linear accelerators (linacs), by evaluating the dosimetric variation and the dose delivery accuracy of volumetric modulated arc therapy (VMAT). Two VitalBeam linacs installed recently in our center were included in this study. For dosimetric data comparison, beam data, such as percentage depth doses...

article

Zw10 is a spindle assembly checkpoint protein that regulates meiotic maturation in mouse oocytes

Yuram Park, Jae-Sung Kim, Jeong Su Oh

Histochemistry and Cell Biology > 2019 > 152 > 3 > 207-215

Faithful chromosome segregation during the cell cycle is ensured by the spindle assembly checkpoint (SAC). Although SAC activity is highly conserved and most organisms share common SAC components, additional proteins that regulate SAC activity to ensure high fidelity chromosome segregation are present in higher eukaryotes. Zw10 is one of these additional SAC components. Although Zw10 has been demonstrated...

article

Reversine induces caspase-dependent apoptosis of human osteosarcoma cells through extrinsic and intrinsic apoptotic signaling pathways

Jae-Sung Kim, In-A Cho, Kyeong-Rok Kang, HyangI Lim, more

Genes & Genomics > 2019 > 41 > 6 > 657-665

Background The 2-(4-morpholinoanilino)-6-cyclohexylaminopurine (reversine) acts as a chemopreventive agent and induces apoptotic cell death in various cancer cells. However, the anticancer effects of reversine on osteosarcoma cells are not clearly established. Objective The purpose of this study was to investigate the effect of reversine on cell proliferation and induction of apoptosis in human...

article

Formononetin Antagonizes the Interleukin-1β-Induced Catabolic Effects Through Suppressing Inflammation in Primary Rat Chondrocytes

In-A Cho, Tae-Hyeon Kim, HyangI Lim, Jong-Hyun Park, more

Inflammation > 2019 > 42 > 4 > 1426-1440

In the present study, we demonstrated the anti-catabolic effects of formononetin, a phytoestrogen derived from herbal plants, against interleukin-1β (IL-1β)-induced severe catabolic effects in primary rat chondrocytes and articular cartilage. Formononetin did not affect the viability of primary rat chondrocytes in both short- (24 h) and long-term (21 days) treatment periods. Furthermore, formononetin...

article

Delta-radiomics signature predicts treatment outcomes after preoperative chemoradiotherapy and surgery in rectal cancer

Seung Hyuck Jeon, Changhoon Song, Eui Kyu Chie, Bohyoung Kim, more

Radiation Oncology > 2019 > 14 > 1 > 1-10

Background To develop and compare delta-radiomics signatures from 2- (2D) and 3-dimensional (3D) features that predict treatment outcomes following preoperative chemoradiotherapy (CCRT) and surgery for locally advanced rectal cancer. Methods In total, 101 patients (training cohort, n = 67; validation cohort, n = 34) with locally advanced rectal adenocarcinoma between 2008 and 2015 were included...

article

Performance Evaluation of a Transmission Reference Detector for Commissioning Beam Data in a Wedge Field

Seonghee Kang, Jin-Beom Chung, Changhoon Song, Keun-Yong Eom, more

Journal of the Korean Physical Society > 2019 > 74 > 4 > 405-413

The purpose of this study is to evaluate the performance of a “stealth chamber” as a novel reference detector for measuring the commissioning beam data for a wedge field. The stealth chamber is a transmission ionization chamber intended to be used as a reference chamber for relative dosimetry. The percentage depth doses (PDDs) and the dose profiles of 6-, 8-, and 10-MV photon beams of four wedge filters...

article

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

Yi Na Yoon, Min Ho Choe, Kwan-Young Jung, Sang-Gu Hwang, more

BMC Cancer > 2018 > 18 > 1 > 1-13

Background Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the antitumor mechanism of MASTL targeting in cancer cells is still unclear. Methods MASTL expression was evaluated by using breast cancer tissue microarrays and public cancer databases...

article

Molecular subtype predicts incidence and prognosis of brain metastasis from breast cancer in SEER database

Yi-Jun Kim, Jae-Sung Kim, In Ah Kim

Journal of Cancer Research and Clinical Oncology > 2018 > 144 > 9 > 1803-1816

Purpose To evaluate the impact of molecular subtype on incidence and prognosis of brain metastasis from breast cancer. Methods The Surveillance, Epidemiology, and End Results (SEER) 18 registry was used to select breast cancer patients from 2010 to 2014. Molecular subtypes were classified as luminal A (hormone receptor [HR]+/human epidermal growth factor receptor 2 [HER2]-), luminal B (HR+/HER2+),...

article

The small molecule AU14022 promotes colorectal cancer cell death via p53‐mediated G2/M‐phase arrest and mitochondria‐mediated apoptosis

Hwani Ryu, Ky‐Youb Nam, Jae Sung Kim, Sang‐Gu Hwang, more

Journal of Cellular Physiology > 233 > 6 > 4666 - 4676

The p53 tumor suppressor plays critical roles in cell cycle regulation and apoptotic cell death, with its activation capable of sensitizing cancer cells to radiotherapy or chemotherapy. To identify small molecules that induce apoptosis via increased p53 transcriptional activity, we used a novel in‐house library containing 96 small‐molecule compounds. Using a cell‐based screening method with a p53‐responsive...

article

Hippocampus-sparing radiotherapy using volumetric modulated arc therapy (VMAT) to the primary brain tumor: the result of dosimetric study and neurocognitive function assessment

Kyung Su Kim, Chan Woo Wee, Jin-Yong Seok, Joo Wan Hong, more

Radiation Oncology > 2018 > 13 > 1 > 1-8

Background We hypothesized that hippocampal-sparing radiotherapy via volumetric modulated arc therapy (VMAT) could preserve the neurocognitive function (NCF) of patients with primary brain tumors treated with radiotherapy. Methods We reviewed data from patients with primary brain tumors who underwent hippocampal-sparing brain radiotherapy via VMAT between February 2014 and December 2015. The optimization...

article

Aqueous extract of Codium fragile alleviates osteoarthritis through the MAPK/NF-κB pathways in IL-1β-induced rat primary chondrocytes and a rat osteoarthritis model

Sung-Min Moon, Seul Ah Lee, Seul Hee Han, Bo-Ram Park, more

Biomedicine & Pharmacotherapy > 2018 > 97 > C > 264-270

Codium fragile (Suringar) Hariot has been used as a potential remedy in traditional medicine because of its anti-inflammatory and anti-oxidant effects. Osteoarthritis is a chronic progressive joint disease, characterized by complex mechanisms related to inflammation and degeneration of articular cartilage. In this study, we aimed to evaluate the cartilage protective effect of an aqueous extract of...

article

Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cells

Myeong-ok Kim, Min Ho Choe, Yi Na Yoon, Jiyeon Ahn, more

Biochemical Pharmacology > 2017 > 144 > C > 78-89

Protein phosphatase 2A (PP2A) is a critical tumor suppressor complex responsible for the inactivation of various oncogenes. Recently, PP2A reactivation has emerged asan anticancer strategy. Cancerous inhibitor of protein phosphatase 2A (CIP2A), an endogenous inhibitor of PP2A, is upregulated in many cancer cells, including non-small cell lung cancer (NSCLC) cells. We demonstrated that the antihelminthic...

article

Aqueous extract of Codium fragile suppressed inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells and carrageenan-induced rats

Seul Ah Lee, Sung-Min Moon, Yun Hee Choi, Seul Hee Han, more

Biomedicine & Pharmacotherapy > 2017 > 93 > C > 1055-1064

Codium fragile (Suringar) Hariot has been used in Oriental medicine for the treatment of enterobiasis, dropsy, and dysuria and has been shown to have various biological effects. In this study, we evaluated the anti-inflammatory effects of aqueous extract of C. fragile (AECF) using in vitro and in vivo models. Nitric oxide (NO), prostaglandin E₂ (PGE₂), inflammatory-related mRNAs, and proteins were...

article

Peroxiredoxins are required for spindle assembly, chromosome organization, and polarization in mouse oocytes

Hyuk-Joon Jeon, Yong Seok Park, Dong-Hyung Cho, Jae-Sung Kim, more

Biochemical and Biophysical Research Communications > 2017 > 489 > 2 > 193-199

Peroxiredoxins (Prxs) are highly conserved antioxidant enzymes and are implicated in multiple biological processes; however, their function in oocyte meiosis has not been studied. Here we show that inhibition of Prx I and II results in spindle defects, chromosome disorganization, and impaired polarization in mouse oocytes. Prx I was specifically localized at the spindle, whereas Prx II was enriched...

article

Oncologic relevance of magnetic resonance imaging–detected threatened mesorectal fascia for patients with mid or low rectal cancer: A longitudinal analysis before and after long-course, concurrent chemoradiotherapy

Il Tae Son, Young Hoon Kim, Kyoung Ho Lee, Sung IL Kang, more

Surgery > 2017 > 162 > 1 > 152-163

The oncologic importance of threatened mesorectal fascia detected with magnetic resonance imaging is obscured by the heterogeneity of preoperative treatments. We evaluated the oncologic relevance of threatened mesorectal fascia detected with consecutive magnetic resonance imaging performed before and after long-course, concurrent chemoradiotherapy (LCRT) for mid or low rectal cancer.We evaluated 196...

article

TCTP regulates spindle assembly during postovulatory aging and prevents deterioration in mouse oocyte quality

Hyuk-Joon Jeon, Xiang-Shun Cui, Jing Guo, Jae Man Lee, more

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research > 2017 > 1864 > 7 > 1328-1334

If no fertilization occurs for a prolonged time following ovulation, oocytes experience a time-dependent deterioration in quality both in vivo and in vitro due to processes called postovulatory aging. Because the postovulatory aging of oocytes has marked detrimental effects on embryo development and offspring, many efforts have been made to unveil the underlying mechanisms. Here we showed that translationally...

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INFONA - science communication portal

Search results for: Jae Sung Kim

Swelling Behaviors of Natural Rubber/Solvent Systems Based on the Extended Modified Double Lattice Model

25‐Hydroxycholesterol induces odontoclastic differentiation through RANK–RANKL upregulation and NF‐κB activation in odontoblast‐like MDPC‐23 cells: An in vitro study

TCTP overexpression reverses age‐associated telomere attrition by upregulating telomerase activity in mouse oocytes

Melatonin protects mouse oocytes from DNA damage by enhancing nonhomologous end‐joining repair

Possibility of Interchanging Patients for Beam-Matched Linear Accelerators from the Same Vendor

Zw10 is a spindle assembly checkpoint protein that regulates meiotic maturation in mouse oocytes

Reversine induces caspase-dependent apoptosis of human osteosarcoma cells through extrinsic and intrinsic apoptotic signaling pathways

Formononetin Antagonizes the Interleukin-1β-Induced Catabolic Effects Through Suppressing Inflammation in Primary Rat Chondrocytes

Delta-radiomics signature predicts treatment outcomes after preoperative chemoradiotherapy and surgery in rectal cancer

Performance Evaluation of a Transmission Reference Detector for Commissioning Beam Data in a Wedge Field

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

Molecular subtype predicts incidence and prognosis of brain metastasis from breast cancer in SEER database

The small molecule AU14022 promotes colorectal cancer cell death via p53‐mediated G2/M‐phase arrest and mitochondria‐mediated apoptosis

Hippocampus-sparing radiotherapy using volumetric modulated arc therapy (VMAT) to the primary brain tumor: the result of dosimetric study and neurocognitive function assessment

Aqueous extract of Codium fragile alleviates osteoarthritis through the MAPK/NF-κB pathways in IL-1β-induced rat primary chondrocytes and a rat osteoarthritis model

Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cells

Aqueous extract of Codium fragile suppressed inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells and carrageenan-induced rats

Peroxiredoxins are required for spindle assembly, chromosome organization, and polarization in mouse oocytes

Oncologic relevance of magnetic resonance imaging–detected threatened mesorectal fascia for patients with mid or low rectal cancer: A longitudinal analysis before and after long-course, concurrent chemoradiotherapy

TCTP regulates spindle assembly during postovulatory aging and prevents deterioration in mouse oocyte quality

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