Search results for: Jun Okada

Items from 1 to 20 out of 22 results

article

Additional studies on nicotine exposure in horses: Accurate quantification and elimination profiles of potential biomarkers in plasma and urine

Hideaki Ishii, Mariko Shibuya, Gary Ngai‐Wa Leung, Shozo Yamashita, more

Rapid Communications in Mass Spectrometry > 36 > 23 > n/a - n/a

Rationale For the purpose of doping control, this is the first report of accurate quantification of four critical structural isomers of nicotine metabolites (trans‐3′‐hydroxycotinine, cis‐3′‐hydroxycotinine, 5′‐hydroxycotinine, and N′‐hydroxymethylnorcotinine) in equine plasma and urine for the establishment of their elimination profiles. Besides, the pharmacokinetic studies of trans‐3′‐hydroxycotinine...

article

Detection and longitudinal distribution of GW1516 and its metabolites in equine hair for doping control using liquid chromatography/high‐resolution mass spectrometry

Hideaki Ishii, Mariko Shibuya, Gary Ngai‐Wa Leung, Satoshi Nozawa, more

Rapid Communications in Mass Spectrometry > 35 > 8 > n/a - n/a

Rationale GW1516 is a peroxisome proliferator‐activated receptor‐δ (PPAR‐δ) agonist that is banned in horseracing and equestrian sports. Long‐term detection and longitudinal distribution of GW1516 in the mane of a horse are reported for the first time and this hair analysis could prolong the detection window of GW1516 for doping control. Methods Mane hairs were divided into three segments (0–7,...

article

Metabolic study of GW1516 in equine urine using liquid chromatography/electrospray ionization Q‐Exactive high‐resolution mass spectrometry for doping control

Hideaki Ishii, Mariko Shibuya, Gary Ngai‐Wa Leung, Shozo Yamashita, more

Rapid Communications in Mass Spectrometry > 35 > 5 > n/a - n/a

Rationale The use of GW1516, a peroxisome proliferator‐activated receptor δ (PPAR δ) agonist, is strictly prohibited in both horseracing and equestrian competitions. However, little is known about its metabolic fate in horses. To the best of our knowledge, this is the first reported metabolic study of GW1516 in equine urine. Methods Urine samples obtained from a thoroughbred after nasoesophageal...

article

Doping control analysis of GW1516 in equine plasma using liquid chromatography/electrospray ionization Q‐Exactive high‐resolution mass spectrometry

Hideaki Ishii, Gary Ngai‐Wa Leung, Shozo Yamashita, Masayuki Yamada, more

Rapid Communications in Mass Spectrometry > 34 > 23 > n/a - n/a

Rationale GW1516 is a peroxisome proliferator‐activated receptor‐δ agonist in the class of hormones and metabolic modulators. The use of GW1516 is banned in both horseracing and equestrian competitions. To the best of our knowledge, this is the first metabolic study of GW1516 in horses. Methods After protein precipitation of pre‐ and post‐administration plasma GW1516 samples, the supernatants were...

article

Clinical significance of serum S100 calcium‐binding protein A4 in idiopathic pulmonary fibrosis

Norimichi Akiyama, Hironao Hozumi, Takuya Isayama, Jun Okada, more

Respirology > 25 > 7 > 743 - 749

Background and objective Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with a poor prognosis. There are no established serum biomarkers for predicting the outcomes of IPF. S100 calcium‐binding protein A4 (S100A4) is considered as a marker of fibroblasts; however, its clinical application remains to be investigated. We evaluated the clinical relevance of S100A4 in...

article

Patients assigned to VGPR, PR, and SD in the IMWG response category are composed of heterogeneous population when assessed by the heavy/light chain assay

Yoshikazu Kamiya, Takaaki Chou, Hirokazu Murakami, Hiroshi Handa, more

Hematological Oncology > 37 > 3 > 316 - 318

chapter

An Efficient GPU Parallelization for Arbitrary Collocated Polyhedral Finite Volume Grids and Its Application to Incompressible Fluid Flows

Shashank Jaiswal, Rajesh Reddy, Raja Banerjee, Shingo Sato, more

2016 IEEE 23rd International Conference on High Performance Computing Workshops (HiPCW) > 81 - 89

2016 IEEE 23rd International Conference on High Performance Computing Workshops (HiPCW)

This paper presents GPU parallelization for a computational fluid dynamics solver which works on a mesh consisting of polyhedral cells, where each cell has an arbitrary number of faces and each face has an arbitrary number of vertices. The parallelization is achieved using NVIDIAs compute unified device architecture (CUDA). The developed code specifically targets performance improvement on NVIDIA...

article

Establishment of gene transfer and gene silencing methods in a desiccation-tolerant cell line, Pv11

Yoichiro Sogame, Jun Okada, Shingo Kikuta, Yugo Miyata, more

Extremophiles > 2017 > 21 > 1 > 65-72

Larvae of the African midge Polypedilum vanderplanki show extreme desiccation tolerance, known as anhydrobiosis. Recently, the cultured cell line Pv11 was derived from this species; Pv11 cells can be preserved in the dry state for over 6 months and retain their proliferation potential. Here, we attempted to expand the use of Pv11 cells as a model to investigate the mechanisms underlying anhydrobiosis...

article

Diversity of the expression profiles of late embryogenesis abundant (LEA) protein encoding genes in the anhydrobiotic midge Polypedilum vanderplanki

Rie Hatanaka, Oleg Gusev, Richard Cornette, Sachiko Shimura, more

Planta > 2015 > 242 > 2 > 451-459

Main conclusion In the anhydrobiotic midge Polypedilum vanderplanki , LEA family proteins are likely to play distinct temporal and spatial roles in the larvae throughout the process of desiccation and rehydration. The larvae of the anhydrobiotic midge, P. vanderplanki, which can tolerate almost complete desiccation, accumulate late embryogenesis abundant (LEA) proteins in response to drying...

article

Protein Unfolding Pathway Examined by Pulse Proteolysis using a Super-Stable Protease

Kazufumi Takano, Jun Okada

Biophysical Journal > 2013 > 104 > 2 Supplement 1 > 564a

article

Monoclonal antibodies in man that neutralized H3N2 influenza viruses were classified into three groups with distinct strain specificity: 1968–1973, 1977–1993 and 1997–2003

Jun Okada, Nobuko Ohshima, Ritsuko Kubota-Koketsu, Sayuri Ota, more

Virology > 2010 > 397 > 2 > 322-330

We tried to reveal the strain specificity of neutralizing mAbs against H3N2 influenza viruses in individuals. A large number of B lymphocytes of a pediatrician were collected by apheresis and two Ab libraries were constructed at 2004 and 2007 by using the phage-display technology. The libraries were screened against 12 different H3 strains of flu isolated between 1968 and 2004. Large numbers of clones...

article

Efficacy and safety of mizoribine for the treatment of Sjögren's syndrome: a multicenter open-label clinical trial

Shingo Nakayamada, Kazuyoshi Saito, Hisanori Umehara, Noriyoshi Ogawa, more

Modern Rheumatology > 2007 > 17 > 6 > 464-469

This multicenter clinical trial was performed to evaluate the efficacy and safety of mizoribine for the treatment of Sjögren's syndrome. Fifty-nine patients with a definite diagnosis of Sjögren's syndrome received 150^Smg of mizoribine daily for 16 weeks. The salivary secretion volume was determined at baseline, at weeks 8 and 16 after the start of the study treatment by the Saxon test, and clinical...

article

Activation of lipase in ionic liquids by modification with comb-shaped poly(ethylene glycol)

Kazunori Nakashima, Jun Okada, Tatsuo Maruyama, Noriho Kamiya, more

Science and Technology of Advanced Materials > 2006 > 7 > 7 > 692-698

Outstanding activation of an enzyme in ionic liquids (ILs) has been demonstrated by covalent modification with comb-shaped poly(ethylene glycol) (PEG) (PM ₁₃ ). Candida rugosa lipase modified with PM ₁₃ (PM ₁₃ –CRL) was readily solubilized in all the ILs tested ([Emim][Tf ₂ N], [C ₂ OC ₁ mim][Tf ₂ N] and [C ₂ OHmim][Tf ₂ N]) containing...

article

Coexistence of nodular regenerative hyperplasia of the liver and pulmonary arterial hypertension in patients with connective tissue diseases: report of three cases and review of the literature

Hiroyuki Watabe, Tohru Akahoshi, Jun Okada, Shigehiro Kokubu, more

Modern Rheumatology > 2006 > 16 > 6 > 389-394

Nodular regenerative hyperplasia of the liver (NRH) is known to be a rare condition in patients with connective tissue diseases (CTD). In this report, we document three patients with CTD who had both NRH and pulmonary hypertension (PH). All three patients developed PH during their course and thereafter developed NRH. The clinical course of these patients suggests that circulatory disturbance caused...

article

Ground uplift detected by precise leveling in the Ontake earthquake swarm area, central Japan in 2002–2004

Fumiaki Kimata, Rikio Miyajima, Masayuki Murase, Dudy Darwaman, more

Earth, Planets and Space > 2004 > 56 > 12 > e45-e48

Repeated precise leveling in the earthquake swarm area of Ontake, central Japan has revealed uplift of 3–6 mm in proximity to the epicentral region of the most active earthquake cluster in 2002–2004. Although the uplift is small, the vertical displacement is significant even considering leveling error. This uplift is associated with increases in ³He/⁴He ratios and CO₂ δ¹³C values at a mineral spring...

article

Prospective study of high-dose intravenous immunoglobulin for the treatment of steroid-resistant polymyositis and dermatomyositis

Masako Hara, Masao Kinoshita, Eizo Saito, Hiroshi Hashimoto, more

Modern Rheumatology > 2003 > 13 > 4 > 319-325

High-dose intravenous immunoglobulin (IVIG) therapy has been effective in treating many autoimmune and systemic inflammatory diseases. In the present prospective study, we evaluated the efficacy of IVIG for patients with polymyositis (PM) and dermatomyositis (DM) refractory to treatment with high-dose corticosteroids. PM/DM was defined as steroid-resistant when the muscle strength of a patient did...

article

Epstein-Barr Virus-Associated B-Cell Type Non-Hodgkin’s Lymphoma with Concurrent p53 Protein Expression in a Rheumatoid Arthritis Patient Treated with Methotrexate

Yuko Hirose, Yasufumi Masaki, Jun Okada, Chang Gi Kim, more

International Journal of Hematology > 2002 > 75 > 4 > 412-415

A Japanese male patient received various medications for his long-standing rheumatoid arthritis (stage IV, class II). He developed a mass on the right anterior chest wall after being treated with methotrexate (MTX) for 4 months. A biopsy of the mass showed it to be Epstein Barr virus (EBV)-associated lymphoma of B-cell phenotype stage IE (bulky mass), with positive EBV-encoded small RNAs (EBERs) in...

article

Additive depressor effect of pravastatin beyond its effect on cholesterol in hypertensive patients treated with antihypertensives

Toshio Ikeda, Kunio Yamamoto, Jun Okada, Manabu Hayashida, more

American Journal of Hypertension > 2002 > 15 > 4 Supplement 1 > A38

article

Antihypertensive effect of Nori-peptides derived from red alga porphyra yezoensis in hypertensive patients

Masanobu Saito, Masanobu Kawai, Hiroshi Hagino, Jun Okada, more

American Journal of Hypertension > 2002 > 15 > 4 Supplement 1 > A210

article

T-Cell Type Acute Lymphoblastic Leukemia Following Cyclosporin A Therapy for Aplastic Anemia

Yuko Hirose, Yasufumi Masaki, Kazumi Ebata, Jun Okada, more

International Journal of Hematology > 2001 > 73 > 2 > 226-229

Cyclosporin A (CsA) is used to prevent rejection in transplantation and to treat autoimmune and hematologic diseases such as aplastic anemia. However, the tumor growth-promoting effect of CsA remains controversial. We report the case of a 24-year-old man who developed acute lymphoblastic leukemia of precursor-T-cell origin after 75 months of treatment with CsA for aplastic anemia. The surface antigen...

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INFONA - science communication portal

Search results for: Jun Okada

Additional studies on nicotine exposure in horses: Accurate quantification and elimination profiles of potential biomarkers in plasma and urine

Detection and longitudinal distribution of GW1516 and its metabolites in equine hair for doping control using liquid chromatography/high‐resolution mass spectrometry

Metabolic study of GW1516 in equine urine using liquid chromatography/electrospray ionization Q‐Exactive high‐resolution mass spectrometry for doping control

Doping control analysis of GW1516 in equine plasma using liquid chromatography/electrospray ionization Q‐Exactive high‐resolution mass spectrometry

Clinical significance of serum S100 calcium‐binding protein A4 in idiopathic pulmonary fibrosis

Patients assigned to VGPR, PR, and SD in the IMWG response category are composed of heterogeneous population when assessed by the heavy/light chain assay

An Efficient GPU Parallelization for Arbitrary Collocated Polyhedral Finite Volume Grids and Its Application to Incompressible Fluid Flows

Establishment of gene transfer and gene silencing methods in a desiccation-tolerant cell line, Pv11

Diversity of the expression profiles of late embryogenesis abundant (LEA) protein encoding genes in the anhydrobiotic midge Polypedilum vanderplanki

Protein Unfolding Pathway Examined by Pulse Proteolysis using a Super-Stable Protease

Monoclonal antibodies in man that neutralized H3N2 influenza viruses were classified into three groups with distinct strain specificity: 1968–1973, 1977–1993 and 1997–2003

Efficacy and safety of mizoribine for the treatment of Sjögren's syndrome: a multicenter open-label clinical trial

Activation of lipase in ionic liquids by modification with comb-shaped poly(ethylene glycol)

Coexistence of nodular regenerative hyperplasia of the liver and pulmonary arterial hypertension in patients with connective tissue diseases: report of three cases and review of the literature

Ground uplift detected by precise leveling in the Ontake earthquake swarm area, central Japan in 2002–2004

Prospective study of high-dose intravenous immunoglobulin for the treatment of steroid-resistant polymyositis and dermatomyositis

Epstein-Barr Virus-Associated B-Cell Type Non-Hodgkin’s Lymphoma with Concurrent p53 Protein Expression in a Rheumatoid Arthritis Patient Treated with Methotrexate

Additive depressor effect of pravastatin beyond its effect on cholesterol in hypertensive patients treated with antihypertensives

Antihypertensive effect of Nori-peptides derived from red alga porphyra yezoensis in hypertensive patients

T-Cell Type Acute Lymphoblastic Leukemia Following Cyclosporin A Therapy for Aplastic Anemia

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