Search results for: Xiao-Jun Du

Items from 1 to 20 out of 87 results

article

Association between heart rate variability indices and features of spontaneous ventricular tachyarrhythmias in mice

Mi He, Wei‐Bo Zhao, My‐Nhan Nguyen, Helen Kiriazis, more

Clinical and Experimental Pharmacology and Physiology > 47 > 7 > 1193 - 1202

Direct evidence is limited for the association between heart rate variability (HRV) indices and ventricular tachyarrhythmias (VTAs). While galectin‐3 (Gal‐3) is regarded as a causal factor for cardiac remodelling and a biomarker for arrhythmias, its regulation on VTAs and HVR is unknown. Using aged transgenic (TG) mice with cardiac overexpression of β₂‐adrenoceptors and spontaneous VTAs, we studied...

article

β‐Adrenoceptor activation affects galectin‐3 as a biomarker and therapeutic target in heart disease

Xiao‐Jun Du, Wei‐Bo Zhao, My‐Nhan Nguyen, Qun Lu, more

British Journal of Pharmacology > 176 > 14 > 2449 - 2464

Myocardial fibrosis is a key histopathological component that drives the progression of heart disease leading to heart failure and constitutes a therapeutic target. Recent preclinical and clinical studies have implicated galectin‐3 (Gal‐3) as a pro‐fibrotic molecule and a biomarker of heart disease and fibrosis. However, our knowledge is poor on the mechanism(s) that determine the blood level or...

article

Stimulation of β‐adrenoceptors up‐regulates cardiac expression of galectin‐3 and BIM through the Hippo signalling pathway

Wei‐Bo Zhao, Qun Lu, My‐Nhan Nguyen, Yidan Su, more

British Journal of Pharmacology > 176 > 14 > 2465 - 2481

Background and Purpose Expression of the pro‐fibrotic galectin‐3 and the pro‐apoptotic BIM is elevated in diseased heart or after β‐adrenoceptor stimulation, but the underlying mechanisms are unclear. This question was addressed in the present study. Experimental Approach Wild‐type mice and mice with cardiac transgenic expression of β₂‐adrenoceptors, mammalian sterile‐20 like kinase 1 (Mst1) or...

article

Relaxin mitigates microvascular damage and inflammation following cardiac ischemia–reperfusion

Xiao-Ming Gao, Yidan Su, Shirley Moore, Li-Ping Han, more

Basic Research in Cardiology > 2019 > 114 > 4 > 1-15

Microvascular obstruction (MVO) and leakage (MVL) forms a pivotal part of microvascular damage following cardiac ischemia–reperfusion (IR). We tested the effect of relaxin therapy on MVO and MVL in mice following cardiac IR injury including severity of MVO and MVL, opening capillaries, infarct size, regional inflammation, cardiac function and remodelling, and permeability of cultured endothelial monolayer...

article

Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology

Rudolf A. de Boer, Gilles De Keulenaer, Johann Bauersachs, Dirk Brutsaert, more

European Journal of Heart Failure > 21 > 3 > 272 - 285

Fibrosis is a pivotal player in heart failure development and progression. Measurements of (markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with heart failure, and its treatment may be effective in preventing heart failure and its progression. A lack of pathophysiological insights and uniform definitions has hampered the research in fibrosis and heart failure...

article

Serelaxin attenuates renal inflammation and fibrosis in a mouse model of dilated cardiomyopathy

Beverly Giam, Po‐Yin Chu, Sanjaya Kuruppu, A. Ian Smith, more

Experimental Physiology > 103 > 12 > 1593 - 1602

New Findings What is the central question of this study? The aim was to determine the renoprotective effects of serelaxin in the setting of chronic heart failure. What are the main findings and its importance? Our data indicate that serelaxin can reduce renal fibrosis and inflammation in experimental heart failure. Currently, there are no effective treatments to rescue renal function in heart failure...

article

The role and mechanism of KCa3.1 channels in human monocyte migration induced by palmitic acid

Xiao-Zhen Ma, Zheng-Da Pang, Jun-Hong Wang, Zheng Song, more

Experimental Cell Research > 2018 > 369 > 2 > 208-217

Monocyte migration into diseased tissues contributes to the pathogenesis of diseases. Intermediate-conductance Ca²⁺-activated K⁺ (K_Ca3.1) channels play an important role in cell migration. However, the role of K_Ca3.1 channels in mediating monocyte migration induced by palmitic acid (PA) is still unclear. Using cultured THP-1 cells and peripheral blood mononuclear cells from healthy subjects, we investigated...

article

The actions of relaxin on the human cardiovascular system

Mohsin Sarwar, Xiao‐Jun Du, Thomas B Dschietzig, Roger J Summers

British Journal of Pharmacology > 174 > 10 > 933 - 949

The insulin‐like peptide relaxin, originally identified as a hormone of pregnancy, is now known to exert a range of pleiotropic effects including vasodilatory, anti‐fibrotic, angiogenic, anti‐apoptotic and anti‐inflammatory effects in both males and females. Relaxin produces these effects by binding to a cognate receptor RXFP1 and activating a variety of signalling pathways including cAMP, cGMP and...

article

Inhibition of the Renin-Angiotensin System Post Myocardial Infarction Prevents Inflammation-Associated Acute Cardiac Rupture

Xiao-Ming Gao, Alan Tsai, Annas Al-Sharea, Yidan Su, more

Cardiovascular Drugs and Therapy > 2017 > 31 > 2 > 145-156

Purpose Inhibition of the renin-angiotensin system (RAS) is beneficial in patient management after myocardial infarction (MI). However, whether RAS inhibition also provides cardiac protection in the acute phase of MI is unclear. Methods Male 129sv mice underwent coronary artery occlusion to induce MI, followed by treatment with losartan (L, 20 and 60 mg/kg), perindopril (P, 2 and 6 mg/kg), amlodipine...

article

Expressing an inhibitor of PLCβ1b sustains contractile function following pressure overload

David R. Grubb, Xiao-Ming Gao, Helen Kiriazis, Aya Matsumoto, more

Journal of Molecular and Cellular Cardiology > 2016 > 93 > C > 12-17

The activity of phospholipase Cβ1b (PLCβ1b) is selectively elevated in failing myocardium and cardiac expression of PLCβ1b causes contractile dysfunction. PLCβ1b can be selectively inhibited by expressing a peptide inhibitor that prevents sarcolemmal localization. The inhibitory peptide, PLCβ1b-CT was expressed in heart from a mini-gene using adeno-associated virus (rAAV6-PLCβ1b-CT). rAAV6-PLCβ1b-CT,...

article

Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance

Michael J. Kraakman, Helene L. Kammoun, Tamara L. Allen, Virginie Deswaerte, more

Cell Metabolism > 2016 > 23 > 3 > 563

article

Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling

Miles J. De Blasio, Karina Huynh, Chengxue Qin, Sarah Rosli, more

Free Radical Biology and Medicine > 2015 > 87 > C > 137-147

Diabetes-induced cardiac complications include left ventricular (LV) dysfunction and heart failure. We previously demonstrated that LV phosphoinositide 3-kinase p110α (PI3K) protects the heart against diabetic cardiomyopathy, associated with reduced NADPH oxidase expression and activity. Conversely, in dominant negative PI3K(p110α) transgenic mice (dnPI3K), reduced cardiac PI3K signaling exaggerated...

article

The atypical ‘b’ splice variant of phospholipase Cβ1 promotes cardiac contractile dysfunction

David R. Grubb, Bryony Crook, Yi Ma, Jieting Luo, more

Journal of Molecular and Cellular Cardiology > 2015 > 84 > C > 95-103

The activity of the early signaling enzyme, phospholipase Cβ1b (PLCβ1b), is selectively elevated in diseased myocardium and activity increases with disease progression. We aimed to establish the contribution of heightened PLCβ1b activity to cardiac pathology. PLCβ1b, the alternative splice variant, PLCβ1a, and a blank virus were expressed in mouse hearts using adeno-associated viral vectors (rAAV6-FLAG-PLCβ1b,...

article

Augmented endothelial l‐arginine transport ameliorates pressure‐overload‐induced cardiac hypertrophy

Niwanthi W. Rajapakse, Tamara Johnston, Helen Kiriazis, Jaye P. Chin‐Dusting, more

Experimental Physiology > 100 > 7 > 796 - 804

New FindingsWhat is the central question of this study?What is the potential role of endothelial NO production via overexpression of the l‐arginine transporter, CAT1, as a mitigator of cardiac hypertrophy? What is the main finding and its importance?Augmentation of endothelium‐specific l‐arginine transport via CAT1 can attenuate pressure‐overload‐dependent cardiac hypertrophy and fibrosis. Our findings...

article

Serial changes of mean platelet volume in relation to Killip Class in patients with acute myocardial infarction and primary percutaneous coronary intervention

Xin-Yu Wang, Hai-Yi Yu, You-Yi Zhang, Yu-Peng Wang, more

Thrombosis Research > 2015 > 135 > 4 > 652-658

Mean platelet volume (MPV) is related to the reactivity of platelets. Among survivors of acute myocardial infarction (MI), greater MPV is known to be associated with impaired reperfusion and higher mortality. The aims of the study is to investigate the dynamic changes of MPV and the relation between MPV and cardiac function in patients with acute MI and received primary percutaneous coronary intervention...

article

Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance

Michael J. Kraakman, Helene L. Kammoun, Tamara L. Allen, Virginie Deswaerte, more

Cell Metabolism > 2015 > 21 > 3 > 403-416

Interleukin-6 (IL-6) plays a paradoxical role in inflammation and metabolism. The pro-inflammatory effects of IL-6 are mediated via IL-6 “trans-signaling,” a process where the soluble form of the IL-6 receptor (sIL-6R) binds IL-6 and activates signaling in inflammatory cells that express the gp130 but not the IL-6 receptor. Here we show that trans-signaling recruits macrophages into adipose tissue...

article

Current Advances in Noncoding RNA Relevant to Epigenetic Mechanisms

Prabhu Mathiyalagan, Abdul Waheed Khan, Xiao-Jun Du, Assam El-Osta

Current Molecular Biology Reports > 2015 > 1 > 1 > 29-38

The human genome regulates dynamic patterns of transcript expression and while studies in recent years by the Encyclopedia of DNA Elements (ENCODE) consortium have shown the remarkable complexity of pervasive transcription, it is estimated that less than 2 % of the genome codes for proteins. Multiple lines of experimental evidence now highlight the functional importance of noncoding RNAs (ncRNAs)...

article

Erratum to ‘Differential roles of cardiac and leukocyte derived macrophage migration inhibitory factor in inflammatory responses and cardiac remodelling post myocardial infarction’ [J Mol Cell Cardiol 69 (2014) 32–42]

David A. White, Yidan Su, Peter Kanellakis, Helen Kiriazis, more

Journal of Molecular and Cellular Cardiology > 2014 > 75 > C > 198

article

Epigenetic Regulation of Gene Expression by Long Intergenic Non-Coding RNA Encoded by Cardiac Myosin Heavy Chain Genes

Prabhu Mathiyalagan, Jun Okabe, Harikrishnan Kaipananickal, Xiao-Jun Du, more

Journal of Cardiac Failure > 2014 > 20 > 8 Supplement > S81-S82

article

Differential roles of cardiac and leukocyte derived macrophage migration inhibitory factor in inflammatory responses and cardiac remodelling post myocardial infarction

David A. White, Yidan Su, Peter Kanellakis, Helen Kiriazis, more

Journal of Molecular and Cellular Cardiology > 2014 > 69 > Complete > 32-42

Myocardial infarction (MI) provokes regional inflammation which facilitates the healing, whereas excessive inflammation leads to adverse cardiac remodelling. Our aim was to determine the role of macrophage migration inhibitory factor (MIF) in inflammation and cardiac remodelling following MI. Wild type (WT) or global MIF deficient (MIFKO) mice were subjected to coronary artery occlusion. Compared...

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Search results for: Xiao-Jun Du

Association between heart rate variability indices and features of spontaneous ventricular tachyarrhythmias in mice

β‐Adrenoceptor activation affects galectin‐3 as a biomarker and therapeutic target in heart disease

Stimulation of β‐adrenoceptors up‐regulates cardiac expression of galectin‐3 and BIM through the Hippo signalling pathway

Relaxin mitigates microvascular damage and inflammation following cardiac ischemia–reperfusion

Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology

Serelaxin attenuates renal inflammation and fibrosis in a mouse model of dilated cardiomyopathy

The role and mechanism of KCa3.1 channels in human monocyte migration induced by palmitic acid

The actions of relaxin on the human cardiovascular system

Inhibition of the Renin-Angiotensin System Post Myocardial Infarction Prevents Inflammation-Associated Acute Cardiac Rupture

Expressing an inhibitor of PLCβ1b sustains contractile function following pressure overload

Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance

Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling

The atypical ‘b’ splice variant of phospholipase Cβ1 promotes cardiac contractile dysfunction

Augmented endothelial l‐arginine transport ameliorates pressure‐overload‐induced cardiac hypertrophy

Serial changes of mean platelet volume in relation to Killip Class in patients with acute myocardial infarction and primary percutaneous coronary intervention

Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance

Current Advances in Noncoding RNA Relevant to Epigenetic Mechanisms

Erratum to ‘Differential roles of cardiac and leukocyte derived macrophage migration inhibitory factor in inflammatory responses and cardiac remodelling post myocardial infarction’ [J Mol Cell Cardiol 69 (2014) 32–42]

Epigenetic Regulation of Gene Expression by Long Intergenic Non-Coding RNA Encoded by Cardiac Myosin Heavy Chain Genes

Differential roles of cardiac and leukocyte derived macrophage migration inhibitory factor in inflammatory responses and cardiac remodelling post myocardial infarction

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