Search results for: Dai Wen

Items from 1 to 20 out of 193 results

article

Regulation of Protein Conformation Enables Cell‐Selective Targeting of Virus‐Mimicking Nanoparticles for siRNA Therapy of Glioblastoma

Han Zhu, Yi‐Fan Wang, Zhi‐Gang Wang, Dai‐Wen Pang, more

Advanced Materials > 36 > 29 > n/a - n/a

Orthotopic glioblastoma (GBM) has an aggressive growth pattern and complex pathogenesis, becoming one of the most common and deadly tumors of the central nervous system (CNS). The emergence of RNA therapies offers promise for the treatment of GBM. However, the efficient and precise delivery of RNA drugs to specific tumor cells in the brain with high cellular heterogeneity remains ongoing. Here, a...

article

Biosynthesis of NIR‐II Ag₂Se Quantum Dots with Bacterial Catalase for Photoacoustic Imaging and Alleviating‐Hypoxia Photothermal Therapy

Shi‐Hui Chen, Hengke Liu, Biao Huang, Jie Zheng, more

Small > 20 > 28 > n/a - n/a

Developing the second near‐infrared (NIR‐II) photoacoustic (PA) agent is of great interest in bioimaging. Ag₂Se quantum dots (QDs) are one kind of potential probe for applications in NIR‐II photoacoustic imaging (PAI). However, the surfaces with excess anions of Ag₂Se QDs, which increase the probability of nonradiative transitions of excitons benefiting PA imaging, are not conducive to binding electron...

article

Mapping Extracellular Space Features of Viral Encephalitis to Evaluate the Proficiency of Anti‐Viral Drugs

Lei Wang, Hua‐Jie Chen, Zhi‐Gang Wang, Di Ning, more

Advanced Materials > 36 > 18 > n/a - n/a

The extracellular space (ECS) is an important barrier against viral attack on brain cells, and dynamic changes in ECS microstructure characteristics are closely related to the progression of viral encephalitis in the brain and the efficacy of antiviral drugs. However, mapping the precise morphological and rheological features of the ECS in viral encephalitis is still challenging so far. Here, a robust...

article

Lipid‐Centric Design of Plasma Membrane‐Mimicking Nanocarriers for Targeted Chemotherapeutic Delivery

Di Ning, Zhi‐Gang Wang, Lei Wang, Yi‐Fan Tian, more

Advanced Materials > 36 > 2 > n/a - n/a

The plasma membranes (PM) of mammalian cells contain diverse lipids, proteins, and carbohydrates that are important for systemic recognition and communication in health and disease. Cell membrane coating technology that imparts unique properties of natural plasma membranes to the surface of encapsulated nanoparticles is thus becoming a powerful platform for drug delivery, immunomodulation, and vaccination...

article

“Dual‐Key‐and‐Lock” NIR‐II NSCyanines Enable High‐Contrast Activatable Phototheranostics in Extrahepatic Diseases

Yang Tian, Zhaoming Chen, Senyao Liu, Fapu Wu, more

Angewandte Chemie International Edition > 62 > 38 > n/a - n/a

Conventional cyanine dyes with a symmetric structure are “always‐on”, which can easily accumulate in the liver and display high liver background fluorescence, inevitably interfering the accurate diagnosis and therapy in extrahepatic diseases. We herein report a platform of NIR‐II non‐symmetric cyanine (NSCyanine) dyes by harnessing a non‐symmetric strategy, which are extremely sensitive to pH/viscosity...

article

“Dual‐Key‐and‐Lock” NIR‐II NSCyanines Enable High‐Contrast Activatable Phototheranostics in Extrahepatic Diseases

Yang Tian, Zhaoming Chen, Senyao Liu, Fapu Wu, more

Angewandte Chemie > 135 > 38 > n/a - n/a

article

Vaccinia virus induces EMT‐like transformation and RhoA‐mediated mesenchymal migration

Wei Liu, Jia‐Yin Lu, Ya‐Jun Wang, Xin‐Xin Xu, more

Journal of Medical Virology > 95 > 8 > n/a - n/a

The emerging outbreak of monkeypox is closely associated with the viral infection and spreading, threatening global public health. Virus‐induced cell migration facilitates viral transmission. However, the mechanism underlying this type of cell migration remains unclear. Here we investigate the motility of cells infected by vaccinia virus (VACV), a close relative of monkeypox, through combining multi‐omics...

article

In Situ Self‐Assembly of Fluorogenic RNA Nanozipper Enables Real‐Time Imaging of Single Viral mRNA Translation

Yu‐Peng Zhang, Zhi‐Gang Wang, Yi‐Fan Tian, Lin‐Han Jiang, more

Angewandte Chemie > 135 > 25 > n/a - n/a

Real‐time visualization of individual viral mRNA translation activities in live cells is essential to obtain critical details of viral mRNA dynamics and to detect its transient responses to environmental stress. Fluorogenic RNA aptamers are powerful tools for real‐time imaging of mRNA in live cells, but monitoring the translation activity of individual mRNAs remains a challenge due to their intrinsic...

article

In Situ Self‐Assembly of Fluorogenic RNA Nanozipper Enables Real‐Time Imaging of Single Viral mRNA Translation

Yu‐Peng Zhang, Zhi‐Gang Wang, Yi‐Fan Tian, Lin‐Han Jiang, more

Angewandte Chemie International Edition > 62 > 25 > n/a - n/a

article

Redox Imbalance Triggered Intratumoral Cascade Reaction for Tumor “turn on” Imaging and Synergistic Therapy

Juanzu Liu, Han Zhu, Leping Lin, Wei Zhao, more

Small > 19 > 16 > n/a - n/a

The redox homeostasis in tumors enhances their antioxidant defense ability, limiting reactive oxygen species mediated tumor therapy efficacy. The development of strategies for specific and continuous disruption of the redox homeostasis in tumor cells facilitates the improvement of the cancer therapeutic effect by promoting the apoptosis of tumor cells. Herein, a responsively biodegradable targeting...

article

An Activatable and Reversible Virus‐Mimicking NIR‐II Nanoprobe for Monitoring the Progression of Viral Encephalitis

Hua‐Jie Chen, Ying Qin, Zhi‐Gang Wang, Lei Wang, more

Angewandte Chemie International Edition > 61 > 39 > n/a - n/a

Viral encephalitis is an inflammatory disease of the brain parenchyma and caused by various viral infections. In vivo monitoring of the progression of viral infections can aid accurate diagnosis of viral encephalitis and effective intervention. We developed an activatable and reversible virus‐mimicking near‐infrared II nanoprobe consisting of an Fe²⁺‐coordinated, viral protein‐decorated vesicle encapsulating...

article

An Activatable and Reversible Virus‐Mimicking NIR‐II Nanoprobe for Monitoring the Progression of Viral Encephalitis

Hua‐Jie Chen, Ying Qin, Zhi‐Gang Wang, Lei Wang, more

Angewandte Chemie > 134 > 39 > n/a - n/a

article

Near‐Infrared‐II Quantum Dots for In Vivo Imaging and Cancer Therapy

Lu‐Lu Chen, Liang Zhao, Zhi‐Gang Wang, Shu‐Lin Liu, more

Small > 18 > 8 > n/a - n/a

In vivo fluorescence imaging can perform real‐time, noninvasive, and high spatiotemporal resolution imaging to accurately obtain the dynamic biological information in vivo, which plays significant roles in the early diagnosis and treatment of cancer. However, traditional in vivo fluorescence imaging usually operates in the visible and near‐infrared (NIR)‐I windows, which are severely interfered by...

article

Spatiotemporal Quantification of Endosomal Acidification on the Viral Journey

Zhi‐Gang Wang, Liang Zhao, Lu‐Lu Chen, Hao‐Yang Liu, more

Small > 18 > 2 > n/a - n/a

Many enveloped viruses utilize endocytic pathways and vesicle trafficking to infect host cells, where the acidification of virus‐containing endosomes triggers the virus‐endosome fusion events. Therefore, simultaneous correlation of intracellular location, local pH, and individual virus dynamics is important for gaining insight into viral infection mechanisms. Here, an imaging approach is developed...

article

Visualization of Vaccine Dynamics with Quantum Dots for Immunotherapy

Junlin Sun, Feng Liu, Wenqian Yu, Dandan Fu, more

Angewandte Chemie > 133 > 45 > 24477 - 24485

The direct visualization of vaccine fate is important to investigate its immunoactivation process to elucidate the detailed molecular reaction process at single‐molecular level. Yet, visualization of the spatiotemporal trafficking of vaccines remains poorly explored. Here, we show that quantum dot (QD) nanomaterials allow for monitoring vaccine dynamics and for amplified immune response. Synthetic...

article

Visualization of Vaccine Dynamics with Quantum Dots for Immunotherapy

Junlin Sun, Feng Liu, Wenqian Yu, Dandan Fu, more

Angewandte Chemie International Edition > 60 > 45 > 24275 - 24283

article

Spectrally Combined Encoding for Profiling Heterogeneous Circulating Tumor Cells Using a Multifunctional Nanosphere‐Mediated Microfluidic Platform

Ling‐Ling Wu, Zhi‐Ling Zhang, Man Tang, Dong‐Liang Zhu, more

Angewandte Chemie International Edition > 59 > 28 > 11240 - 11244

Comprehensive phenotypic profiling of heterogeneous circulating tumor cells (CTCs) at single‐cell resolution has great importance for cancer management. Herein, a novel spectrally combined encoding (SCE) strategy was proposed for multiplex biomarker profiling of single CTCs using a multifunctional nanosphere‐mediated microfluidic platform. Different cellular biomarkers uniquely labeled by multifunctional...

article

Spectrally Combined Encoding for Profiling Heterogeneous Circulating Tumor Cells Using a Multifunctional Nanosphere‐Mediated Microfluidic Platform

Ling‐Ling Wu, Zhi‐Ling Zhang, Man Tang, Dong‐Liang Zhu, more

Angewandte Chemie > 132 > 28 > 11336 - 11340

article

Molecularly Engineered Macrophage‐Derived Exosomes with Inflammation Tropism and Intrinsic Heme Biosynthesis for Atherosclerosis Treatment

Guanghao Wu, Jinfeng Zhang, Qianru Zhao, Wanru Zhuang, more

Angewandte Chemie > 132 > 10 > 4097 - 4103

Atherosclerosis (AS) is a major contributor to cardiovascular diseases worldwide, and alleviating inflammation is a promising strategy for AS treatment. Here, we report molecularly engineered M2 macrophage‐derived exosomes (M2 Exo) with inflammation‐tropism and anti‐inflammatory capabilities for AS imaging and therapy. M2 Exo are derived from M2 macrophages and further electroporated with FDA‐approved...

article

Molecularly Engineered Macrophage‐Derived Exosomes with Inflammation Tropism and Intrinsic Heme Biosynthesis for Atherosclerosis Treatment

Guanghao Wu, Jinfeng Zhang, Qianru Zhao, Wanru Zhuang, more

Angewandte Chemie International Edition > 59 > 10 > 4068 - 4074

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INFONA - science communication portal

Search results for: Dai Wen

Regulation of Protein Conformation Enables Cell‐Selective Targeting of Virus‐Mimicking Nanoparticles for siRNA Therapy of Glioblastoma

Biosynthesis of NIR‐II Ag₂Se Quantum Dots with Bacterial Catalase for Photoacoustic Imaging and Alleviating‐Hypoxia Photothermal Therapy

Mapping Extracellular Space Features of Viral Encephalitis to Evaluate the Proficiency of Anti‐Viral Drugs

Lipid‐Centric Design of Plasma Membrane‐Mimicking Nanocarriers for Targeted Chemotherapeutic Delivery

“Dual‐Key‐and‐Lock” NIR‐II NSCyanines Enable High‐Contrast Activatable Phototheranostics in Extrahepatic Diseases

“Dual‐Key‐and‐Lock” NIR‐II NSCyanines Enable High‐Contrast Activatable Phototheranostics in Extrahepatic Diseases

Vaccinia virus induces EMT‐like transformation and RhoA‐mediated mesenchymal migration

In Situ Self‐Assembly of Fluorogenic RNA Nanozipper Enables Real‐Time Imaging of Single Viral mRNA Translation

In Situ Self‐Assembly of Fluorogenic RNA Nanozipper Enables Real‐Time Imaging of Single Viral mRNA Translation

Redox Imbalance Triggered Intratumoral Cascade Reaction for Tumor “turn on” Imaging and Synergistic Therapy

An Activatable and Reversible Virus‐Mimicking NIR‐II Nanoprobe for Monitoring the Progression of Viral Encephalitis

An Activatable and Reversible Virus‐Mimicking NIR‐II Nanoprobe for Monitoring the Progression of Viral Encephalitis

Near‐Infrared‐II Quantum Dots for In Vivo Imaging and Cancer Therapy

Spatiotemporal Quantification of Endosomal Acidification on the Viral Journey

Visualization of Vaccine Dynamics with Quantum Dots for Immunotherapy

Visualization of Vaccine Dynamics with Quantum Dots for Immunotherapy

Spectrally Combined Encoding for Profiling Heterogeneous Circulating Tumor Cells Using a Multifunctional Nanosphere‐Mediated Microfluidic Platform

Spectrally Combined Encoding for Profiling Heterogeneous Circulating Tumor Cells Using a Multifunctional Nanosphere‐Mediated Microfluidic Platform

Molecularly Engineered Macrophage‐Derived Exosomes with Inflammation Tropism and Intrinsic Heme Biosynthesis for Atherosclerosis Treatment

Molecularly Engineered Macrophage‐Derived Exosomes with Inflammation Tropism and Intrinsic Heme Biosynthesis for Atherosclerosis Treatment

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