Search results for: Ki Whan Hong

Items from 1 to 20 out of 37 results

article

Cilostazol add-on therapy for celecoxib synergistically inhibits proinflammatory cytokines by activating IL-10 and SOCS3 in the synovial fibroblasts of patients with rheumatoid arthritis

Yi Sle Lee, Sang Yeob Lee, So Youn Park, Sung Won Lee, more

Inflammopharmacology > 2019 > 27 > 6 > 1205-1216

Cilostazol (an inhibitor of phosphodiesterase type III) has potent anti-inflammatory effects, and celecoxib (a COX-2 specific inhibitor) has been reported to improve the unsatisfactory profile of NSAIDs. This study investigated the synergistic anti-arthritic potential of a multitarget-based cotreatment, in which cilostazol was used as an add-on therapy for celecoxib, using the synovial fibroblasts...

article

SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis

So Youn Park, Sung Won Lee, Hye Young Kim, Sang Yeob Lee, more

Journal of Molecular Medicine > 2016 > 94 > 8 > 921-931

Monocyte-to-macrophage differentiation plays a central role in the pathophysiology of rheumatoid arthritis (RA)-associated inflammation because it results in the secretions of various inflammatory mediators in inflamed synovium, and thus, this differentiation is viewed as a clinical target. We aimed to determine whether SIRT1 inhibits the differentiation of monocytes from RA patients into macrophages...

article

Anti-depressant effects of phosphodiesterase 3 inhibitor cilostazol in chronic mild stress-treated mice after ischemic stroke

Yu Ri Kim, Ha Neui Kim, Ki Whan Hong, Hwa Kyoung Shin, more

Psychopharmacology > 2016 > 233 > 6 > 1055-1066

Rationale Phosphodiesterase 3 (PDE3) inhibitor cilostazol ameliorates negative effects of cerebral hypoperfusion against cerebral ischemic injury through the phosphodiesterase 3-cyclic adenosine monophosphate (cAMP) signaling cascade. Objectives We investigated the question of whether cilostazol would have an anti-depressant effect on chronic mild stress (CMS)-treated mice after ischemic stroke...

article

Suppression of RANKL-induced osteoclast differentiation by cilostazol via SIRT1-induced RANK inhibition

So Youn Park, Sung Won Lee, Hye Young Kim, Sang Yeob Lee, more

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease > 2015 > 1852 > 10(PA) > 2137-2144

Osteoclasts are bone-specific multinucleated cells generated by differentiation of monocyte/macrophage hematopoietic lineages and degrade bone matrix by secretion of lytic enzymes. The regulation of osteoclast differentiation provides a potential strategy for treatment of bone-lytic damage. In this study, cilostazol, an inhibitor of type III phosphodiesterase, inhibited RANKL [receptor activator of...

article

HMGB1 induces angiogenesis in rheumatoid arthritis via HIF‐1α activation

So Youn Park, Sung Won Lee, Hye Young Kim, Won Suk Lee, more

European Journal of Immunology > 45 > 4 > 1216 - 1227

High‐mobility group box protein 1 (HMGB1), a nonhistone nuclear protein and a cytokine mediator, is implicated in the pathogenesis of rheumatoid arthritis (RA). Extracellular HMGB1 binds to its receptors and triggers downstream signal cascade leading to the perpetuation of synovitis and local tissue invasion. Here, we investigated a novel role of HMGB1 in regulating hypoxia‐inducible factor (HIF)‐1α...

article

Cilostazol suppresses β‐amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1‐coupled retinoic acid receptor‐β

Hye Rin Lee, Hwa Kyoung Shin, So Youn Park, Hye Young Kim, more

Journal of Neuroscience Research > 92 > 11 > 1581 - 1590

The accumulation of plaques of β‐amyloid (Aβ) peptides, a hallmark of Alzheimer's disease, results from the sequential cleavage of amyloid precursor protein (APP) by activation of β‐ and γ‐secretases. However, the production of Aβ can be avoided by alternate cleavage of APP by α‐and γ‐secretases. We hypothesized that cilostazol attenuates Aβ production by increasing a disintegrin and metalloproteinase...

article

Attenuation of β‐amyloid‐induced tauopathy via activation of CK2α/SIRT1: Targeting for cilostazol

Hye Rin Lee, Hwa Kyoung Shin, So Youn Park, Hye Young Kim, more

Journal of Neuroscience Research > 92 > 2 > 206 - 217

β‐Amyloid (Aβ) deposits and hyperphosphorylated tau aggregates are the chief hallmarks in the Alzheimer's disease (AD) brains, but the strategies for controlling these pathological events remain elusive. We hypothesized that CK2‐coupled SIRT1 activation stimulated by cilostazol suppresses tau acetylation (Ac‐tau) and tau phosphorylation (P‐tau) by inhibiting activation of P300 and GSK3β. Aβ was endogenously...

article

RhoA/ROCK-dependent pathway is required for TLR2-mediated IL-23 production in human synovial macrophages: Suppression by cilostazol

So Youn Park, Sung Won Lee, Won Suk Lee, Byung Yong Rhim, more

Biochemical Pharmacology > 2013 > 86 > 9 > 1320-1327

IL-23 is produced by antigen presenting cells and plays critical roles in immune response in rheumatoid arthritis. In this study, we investigated whether the RhoA/Rho-kinase pathway is required to elevate TLR2-mediated IL-23 production in synovial macrophages from patients with rheumatoid arthritis (RA), and then examined the suppressive effect of cilostazol on these pathways. IL-23 production was...

article

Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: Pharmacologic and clinical significance

Hye Young Kim, Sung Won Lee, So Youn Park, Seung Hoon Baek, more

Life Sciences > 2012 > 91 > 7-8 > 250-257

This study aimed to assess the beneficial effects of the concurrent administration of cilostazol and methotrexate (MTX) on the synovial fibroblasts obtained from patients with rheumatoid arthritis (RA), and in a mouse model of collagen-induced arthritis (CIA).Production of TNF-α, IL-1β, IL-6 and MCP-1 on synovial fibroblasts from RA patients was determined by RT-PCR. Cell proliferation, viability...

article

Protection by cilostazol against amyloid‐β_1–40‐induced suppression of viability and neurite elongation through activation of CK2α in HT22 mouse hippocampal cells

Hye Rin Lee, So Youn Park, Hye Young Kim, Hwa Kyoung Shin, more

Journal of Neuroscience Research > 90 > 8 > 1566 - 1576

Amyloid‐β peptide (Aβ) deposits in the brain are critical in the neurotoxicity induced by Aβ. This study elucidates the underlying signaling pathway by which cilostazol protects HT22 neuronal cells from Aβ_1–40 (3–30 μM)‐induced deterioration of cell proliferation, viability, and neurite elongation. Cilostazol rescued HT22 cells from the apoptotic cell death induced by Aβ toxicity through the downregulation...

article

Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid β-induced cognitive deficits associated with decreased amyloid β accumulation

Sun Haeng Park, Ji Hyun Kim, Sun Sik Bae, Ki Whan Hong, more

Biochemical and Biophysical Research Communications > 2011 > 408 > 4 > 602-608

Alzheimer’s disease (AD), which is characterized by progressive cognitive impairment, is the most common neurodegenerative disease. Here, we investigated the preventive effect of a phosphodiesterase III inhibitor, cilostazol against cognitive decline in AD mouse model. In vitro studies using N2a cells stably expressing human amyloid precursor protein Swedish mutation (N2aSwe) showed that cilostazol...

article

Induction of heme oxygenase-1 expression by cilostazol contributes to its anti-inflammatory effects in J774 murine macrophages

So Youn Park, Sung Won Lee, Seung Hoon Baek, Seung Jin Lee, more

Immunology Letters > 2011 > 136 > 2 > 138-145

The effects of cilostazol on stimulating heme oxygenase (HO)-1 expression including signal pathways and suppression of inflammatory cytokines and molecules were studied. Cilostazol stimulation time (1–8h)- and concentration (1–30μM)-dependently increased the HO-1 mRNA and protein expression associated with increased HO-1 activity, as did cobalt protoporphyrin IX (1–3μM) in J774 macrophages. In addition,...

article

Cilostazol enhances integrin‐dependent homing of progenitor cells by activation of camp‐dependent protein kinase in synergy with Epac1

Dong Hyung Lee, Hye Rin Lee, Hwa Kyoung Shin, So Youn Park, more

Journal of Neuroscience Research > 89 > 5 > 650 - 660

Recruitment and adhesion of exogenous endothelial progenitor cells (EPCs) or endogenously mobilized bone marrow mononuclear cells (BM MNCs) to the sites of ischemia is an important focus of cell therapy. This study sought to determine whether cilostazol enhances integrin‐dependent homing of progenitor cells both in vitro and in vivo. In the in vitro experiments with human umbilical cord blood (HUCB)‐derived...

article

Protective Effect of Rebamipide Against Helicobacter pylori-CagA-Induced Effects on Gastric Epithelial Cells

Kyung Hwa Lee, Jee-Yeon Kim, Woo-Kyung Kim, Dong-Hun Shin, more

Digestive Diseases and Sciences > 2011 > 56 > 2 > 441-448

Background Helicobacter pylori CagA dysregulates cell signaling pathways and leads to targeted transcriptional up-regulation of genes implicated in gastric cell injury. The aim of this study was to determine the effects of rebamipide on CagA-induced effects on gastric epithelial cells. We investigated the effects of rebamipide treatment (pre- or post-treatment before or after CagA transfection) on...

article

Transcriptional activation of peroxisome proliferator-activated receptor-γ requires activation of both protein kinase A and Akt during adipocyte differentiation

Sang-pil Kim, Jung Min Ha, Sung Ji Yun, Eun Kyoung Kim, more

Biochemical and Biophysical Research Communications > 2010 > 399 > 1 > 55-59

Peroxisome proliferator-activated receptor-γ (PPAR-γ) is required for the conversion of pre-adipocytes. However, the mechanism underlying activation of PPAR-γ is unclear. Here we showed that cAMP-induced activation of protein kinase A (PKA) and Akt is essential for the transcriptional activation of PPAR-γ. Hormonal induction of adipogenesis was blocked by a phosphatidylinositol 3-kinase (PI3K) inhibitor...

article

Cilostazol enhances neovascularization in the mouse hippocampus after transient forebrain ischemia

Hwa Kyoung Shin, Hye Rin Lee, Dong Hyung Lee, Ki Whan Hong, more

Journal of Neuroscience Research > 88 > 10 > 2228 - 2238

Cilostazol is known to be a specific type III phosphodiesterase inhibitor, which promotes increased intracellular cAMP levels. We assessed the effect of cilostazol on production of angioneurins and chemokines and recruitment of new endothelial cells for vasculogenesis in a mouse model of transient forebrain ischemia. Pyramidal cell loss was prominently evident 3–28 days postischemia, which was markedly...

article

Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2‐linked heme oxygenase 1 induction

So Youn Park, Sung Won Lee, Hwa Kyoung Shin, Won Tae Chung, more

Arthritis & Rheumatology > 62 > 3 > 732 - 741

ObjectiveTo assess the effects of cilostazol in inhibiting proliferation and enhancing apoptosis in synovial cells from patients with rheumatoid arthritis (RA). MethodsSynovial cell proliferation was measured by MTT assay. The expression of NF‐κB, IκBα, Bcl‐2, Bax, heme oxygenase 1 (HO‐1), and Nrf2 was determined by Western blotting. ResultsCilostazol suppressed synovial cell proliferation by arresting...

article

Cilostazol preserves CA1 hippocampus and enhances generation of immature neuroblasts in dentate gyrus after transient forebrain ischemia in rats

Jeong Hyun Lee, Hwa Kyoung Shin, So Youn Park, Chi Dae Kim, more

Experimental Neurology > 2009 > 215 > 1 > 87-94

In the present study, cerebral ischemia was induced by a 10 min transient bilateral common carotid artery occlusion in rats combined with arterial blood pressure lowering to 37–42 mm Hg during occlusion. When histologically evaluated at 7 and 28 days after the forebrain ischemia (DAI) by staining with cresyl violet and Fluoro-Jade, the hippocampal CA1 region was most prominently damaged. At 7 DAI,...

article

Cilostazol increases 3T3-L1 preadipocyte differentiation with improved glucose uptake associated with activation of peroxisome proliferator-activated receptor-γ transcription

So Youn Park, Jeong Hyun Lee, Ki Young Kim, Eun Kyoung Kim, more

Atherosclerosis > 2008 > 201 > 2 > 258-265

In the present study, we assessed that cilostazol stimulates differentiation of 3T3-L1 fibroblasts into adipocytes, and to improve insulin sensitivity in conjunction with PPARγ transcriptional activity. Upon treatment of COS-7 cells and human umbilical vein endothelial cells (HUVECs) with cilostazol (10 and 30μM), endogenous PPARγ transcriptional activity was significantly elevated in both cells as...

article

APE1/Ref-1 promotes the effect of Angiotensin II on Ca²⁺-activated K⁺ channel in human endothelial cells via suppression of NADPH Oxidase

Won Sun Park, Eun A. Ko, In Duk Jung, Youn Kyoung Son, more

Archives of Pharmacal Research > 2008 > 31 > 10 > 1291-1301

The effects of angiotensin II (Ang II) on whole-cell large conductance Ca²⁺-activated K⁺ (BK_Ca) currents was investigated in control and Apurinic/apyrimidinic endonuclease1/redox factor 1 (APE1/Ref-1)-overexpressing human umbilical vein endothelial cells (HUVECs). Ang II blocked the BK_Ca current in a dose-dependent fashion, and this inhibition was greater in APE1/Ref-1-overexpressing HUVECs than in...

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Search results for: Ki Whan Hong

Cilostazol add-on therapy for celecoxib synergistically inhibits proinflammatory cytokines by activating IL-10 and SOCS3 in the synovial fibroblasts of patients with rheumatoid arthritis

SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis

Anti-depressant effects of phosphodiesterase 3 inhibitor cilostazol in chronic mild stress-treated mice after ischemic stroke

Suppression of RANKL-induced osteoclast differentiation by cilostazol via SIRT1-induced RANK inhibition

HMGB1 induces angiogenesis in rheumatoid arthritis via HIF‐1α activation

Cilostazol suppresses β‐amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1‐coupled retinoic acid receptor‐β

Attenuation of β‐amyloid‐induced tauopathy via activation of CK2α/SIRT1: Targeting for cilostazol

RhoA/ROCK-dependent pathway is required for TLR2-mediated IL-23 production in human synovial macrophages: Suppression by cilostazol

Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: Pharmacologic and clinical significance

Protection by cilostazol against amyloid‐β_1–40‐induced suppression of viability and neurite elongation through activation of CK2α in HT22 mouse hippocampal cells

Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid β-induced cognitive deficits associated with decreased amyloid β accumulation

Induction of heme oxygenase-1 expression by cilostazol contributes to its anti-inflammatory effects in J774 murine macrophages

Cilostazol enhances integrin‐dependent homing of progenitor cells by activation of camp‐dependent protein kinase in synergy with Epac1

Protective Effect of Rebamipide Against Helicobacter pylori-CagA-Induced Effects on Gastric Epithelial Cells

Transcriptional activation of peroxisome proliferator-activated receptor-γ requires activation of both protein kinase A and Akt during adipocyte differentiation

Cilostazol enhances neovascularization in the mouse hippocampus after transient forebrain ischemia

Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2‐linked heme oxygenase 1 induction

Cilostazol preserves CA1 hippocampus and enhances generation of immature neuroblasts in dentate gyrus after transient forebrain ischemia in rats

Cilostazol increases 3T3-L1 preadipocyte differentiation with improved glucose uptake associated with activation of peroxisome proliferator-activated receptor-γ transcription

APE1/Ref-1 promotes the effect of Angiotensin II on Ca²⁺-activated K⁺ channel in human endothelial cells via suppression of NADPH Oxidase

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