Some of the most troublesome side-effects of SSRI treatment are of a sexual kind like decreased libido, delay in or inability to achieve orgasm or even complete anorgasmia. Sexual side effects tend to be dose related but generally do not significantly improve over time.Mirtazapine is a novel antidepressant with a unique mode of action which can be best abbreviated as a Noradrenergic and specific Serotonergic Antidepressant NaSSA. This particular mode of action, involving both the noradrenergic and serotonergic neurotransmitter systems, results in a strong clinical efficacy of mirtazapine. Due to Mirtazapine directly blocking the 5-HT2 and 5-HT3 receptors can explain the fact that decrease of libido is equal or lower to a placebo group. On the other hand, sexual dysfunction attributed to Fluoxetine amounts to an average of 34% (1, 2, 3) and due to Paroxetine sexual dysfunction (mainly with disordered ejaculation and lack of libido) we have an average of 47% (1, 2, 3).Our sample consisted of 11 patients (6 M and 5 F) treated with a variety of SSRIs who had to discontinue treatment due to sexual side-effects (decreased libido or anorgasmia). This patients were treated with 30-45 mg Mirtazapine per day following a wash-out period. They were evaluated during a period of six weeks by clinical interview and using the Hamilton Psychiatric Rating Scale for Depression. At the end of this period we had an overall improvement in the Hamilton Psychiatric Rating Scale for Depression and no patient, neither male nor female, complained or sexual difficulties during treatment period.