Apres une transplantation pulmonaire pour mucoviscidose, 2 patients ont presente un syndrome associant hypertension arterielle, cephalees, troubles visuels et crises convulsives generalisees. L'imagerie cerebrale par resonance magnetique a revele des lesions diffuses corticales et sous-corticales predominant en region posterieure. L'exclusion des diagnostics differentiels et la disparition des symptomes a l'arret de la ciclosporine ont confirme le syndrome d'encephalopathie posterieure reversible (SEPR) lie a la ciclosporine. Une prise en charge precoce a permis la disparition des symptomes neurologiques et la regression des images radiologiques.
Following a pulmonary transplantation for cystic fibrosis, 2 patients exhibited a syndrome associating arterial hypertension, headache, visual trouble and generalized seizures. Cerebral magnetic resonance imaging revealed diffuse cortical and subcortical lesions predominantly in posterior regions. The exclusion of alternate diagnoses and the disappearance of the symptoms when the cyclosporine treatment was stopped confirmed the diagnosis of cyclosporine-related reversible posterior encephalopathy syndrome (PRES). Immediate appropriate management resulted in symptom disappearance and regression of radiological images.