The School of Computer and Systems Sciences, Jawaharlal Nehru University, New Delhi organized its second International Conference on Methods and Models in Computer Science, ICM2CS-2010, on December 13–14, 2010. This was the fifth conference organized by the school after the success of the three national conferences and one international conference in past four years. The organizing committee wishes to express their sincere thanks to Prof. B.B. Bhattacharya, Vice Chancellor, Jawaharlal Nehru University for providing support to organize the conference.