This paper deals with Single Carrier/Frequency Domain Equalization (SC/FDE) within a Multi-Input Multi-Output (MU-MIMO) system where a large number of Base Station (BS) antennas is adopted. In this context, we consider either a linear or a low- complexity iterativeDecision Feedback (DF) detection technique which does not require matrix inversion operations. We include a detailed evaluation of BER (Bit Error Rate) performances for uncoded 4- Quadrature Amplitude Modulation (4-QAM) schemes and a MU-MIMO channel with uncorrelated Rayleigh fading. The accuracy of performance results obtained through selected semi-analytical simulation methods is assessed by means of parallel conventional Monte Carlo simulations; these results are discussed in detail, with the help of selected performance bounds. From our performance results, we conclude that a moderately large number of BS antennas is enough to closely approximate the Single-Input Multi-Output (SIMO) Matched-Filter Bound (MFB) performance, especially when using the low- complexity iterative DF technique. We also emphasize the achievable