In today's growing concern for home security, we have developed an advanced security system using integrated digital signature and DNA cryptography. The digital signature is formed using multi-feature biometric traits which includes both fingerprint as well as iris image. We further increase the security by using DNA cryptography which is embedded on a smart card. In order to prevent unauthorized access manually or digitally, we use geo-detection which compares the unregistered devices location with the user's location using any of their personal devices such as smart phone or tab.