This chapter describes certain infectious diseases of the liver which include hepatic abscess, hydatid disease, tuberculosis, acute viral hepatitis, bacterial acute cholangitis, recurrent pyogenic cholangitis, and HIV‐related cholangitis. Hepatic abscesses can be classified as pyogenic, amebic, and fungal. It reaches the liver through the hepatic artery, portal vein, biliary tract, and direct extension from contiguous organs. Hydatid disease involves the liver in 75% of patients, the lung in 15%, and other organs in the remaining 10%. The rupture of hydatid cyst into the biliary tree, circulation, or other adjacent abdominal structures may elicit anaphylaxis due to the antigenic nature of the cyst fluid. Bile duct stones are the most common cause of bacterial cholangitis and are present in 70‐80% of patients with acute cholangitis. Recurrent episodes of bacterial cholangitis lead to the formation of ectasia, focal strictures, and intrahepatic stones.