Engineered Extracellular Vesicles
Extracellular vesicles (EVs)‐based tumor immunotherapy has usually suffered from the limited cross presentation of tumor‐associated antigen by dendritic cells (DCs). In article number 2303541, Jun Hu, Xiangliang Yang, and co‐workers propose a straightforward engineering strategy to construct heat shock proteins 70 (HSP70) highly expressed EVs, which could capture tumor related antigens through the C‐terminal polypeptide binding domain of HSP70 molecules and then stimulate the maturation of DCs via binding to the surface receptors of DCs.