Search results for: Sien Lin

Items from 1 to 20 out of 45 results

article

Molecular Programming of NIR‐IIb‐Emissive Semiconducting Small Molecules for In Vivo High‐Contrast Bioimaging Beyond 1500 nm

Yi Yuan, Zhe Feng, Shengliang Li, Zhongming Huang, more

Advanced Materials > 34 > 19 > n/a - n/a

Materials with long‐wavelength second near‐infrared (NIR‐II) emission are highly desired for in vivo dynamic visualizating of microstructures in deep tissues. Herein, by employing an atom‐programming strategy, a series of highly fluorescent semiconducting oligomers (SOMs) with tunable NIR‐IIb emissions are developed for bioimaging applications. After self‐assembly into nanoparticles (NPs), they show...

article

Probing the role of methyl methacrylate release from spacer materials in induced membrane bone healing

Alexander Stahl, Young Bum Park, Sang‐Hyun Park, Sien Lin, more

Journal of Orthopaedic Research® > 40 > 5 > 1065 - 1074

In the induced membrane (IM) technique for bone reconstruction, a poly(methyl methacrylate) (PMMA) spacer is implanted to induce formation of a foreign body membrane around the defect site. Membrane development is essential for later bone grafting success, yet the mechanism by which the IM promotes bone regeneration remains unknown, as are the ways that spacer composition plays a role in the membrane's...

article

Bone Imaging: Gold Nanoclusters for NIR‐II Fluorescence Imaging of Bones (Small 43/2020)

Deling Li, Qiang Liu, Qingrong Qi, Hui Shi, more

Small > 16 > 43 > n/a - n/a

In article number 2003851, Wang Jia, Zhen Cheng, and co‐workers for the first time present glutathione‐capped gold nanoclusters that demonstrate highly efficient binding capability to hydroxyapatite. The gold nanoclusters can be used for bone imaging with NIR‐II fluorescence and excreted through the renal system, showing great potential for clinical translation.

article

Gold Nanoclusters for NIR‐II Fluorescence Imaging of Bones

Deling Li, Qiang Liu, Qingrong Qi, Hui Shi, more

Small > 16 > 43 > n/a - n/a

Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) holds great promise for deep tissue visualization. Development of novel clinical translatable NIR‐II probes is crucial for realizing the medical applications of NIR‐II fluorescence imaging. Herein, the glutathione‐capped gold nanoclusters (AuNCs, specifically Au₂₅(SG)₁₈) demonstrate highly efficient binding capability to...

article

Asiatic Acid Attenuates Bone Loss by Regulating Osteoclastic Differentiation

Jianping Huang, Haixing Wang, Meiling Huang, Zhixian Zong, more

Calcified Tissue International > 2019 > 105 > 5 > 531-545

Anti-resorptive agents like bisphosphonates have been widely used for the treatment of postmenopausal osteoporosis. However, their long-term safety and efficacy are still controversial. This study is to examine the effect of Asiatic acid (AA) in osteoclastic differentiation, and further to investigate its effect on bone quality in animals. Effect of AA on osteoclastic differentiation was measured...

article

Anisotropic Nanoscale Presentation of Cell Adhesion Ligand Enhances the Recruitment of Diverse Integrins in Adhesion Structures and Mechanosensing‐Dependent Differentiation of Stem Cells

Siu Hong Dexter Wong, Bohan Yin, Boguang Yang, Sien Lin, more

Advanced Functional Materials > 29 > 8 > n/a - n/a

The nanoscale anisotropic patterns of bioactive ligands in the extracellular matrix regulate cell adhesion behaviors. However, the mechanisms of such regulation remain unclear. Here, RGD‐bearing gold nanorods (AuNRs) are conjugated with different aspect ratios (ARs, from 1 to 7) on cell culture substrates to decouple the effect of nanoscale anisotropic presentation of cell adhesive RGD peptides on...

article

Sox11-modified mesenchymal stem cells accelerate cartilage defect repair in SD rats

Liangliang Xu, E Shunmei, Sien Lin, Yonghui Hou, more

Cell and Tissue Research > 2019 > 376 > 2 > 247-255

Cartilage has a limited capacity to heal. Previously, we have shown that overexpression of Sox11 in rMSCs (Rat Mesenchymal Stem Cells) by lentivirus-mediated gene transfer leads to enhanced tri-lineage differentiation and accelerated bone formation in fracture model of rats. We observed that the fracture repair in the rats that received Sox11-modified rMSCs injection proceeded through an endochondral...

article

Remote Control of Intracellular Calcium Using Upconversion Nanotransducers Regulates Stem Cell Differentiation In Vivo

Heemin Kang, Kunyu Zhang, Qi Pan, Sien Lin, more

Advanced Functional Materials > 28 > 41 > n/a - n/a

Remote control of stem cell differentiation in vivo by stimuli‐responsive nanomaterials with the use of tissue‐penetrative stimuli is an appealing strategy for versatile regulation in stem cell therapy. In this study, an upconversion nanotransducer (UCNT)‐based nanocomplex with photolabile caging of chondro‐inductive kartogenin (KGN) and/or either calcium chelator or calcium supplier (caged calcium),...

article

GPR120 is an important inflammatory regulator in the development of osteoarthritis

Yuanfeng Chen, Dan Zhang, Ki Wai Ho, Sien Lin, more

Arthritis Research & Therapy > 2018 > 20 > 1 > 1-11

Background The aim of this study was to investigate the regulatory role of G-protein coupled receptor 120 (GPR120) in the development and progression of osteoarthritis (OA). Methods GPR120 knockout (KO) and wild-type (WT) mice were used to create an animal model of OA by means of anterior cruciate ligament transection (ACLT) surgery. The severity of OA was staged and evaluated by histological examination,...

article

Bioadhesive Polymersome for Localized and Sustained Drug Delivery at Pathological Sites with Harsh Enzymatic and Fluidic Environment via Supramolecular Host–Guest Complexation

Meiling Zhu, Kongchang Wei, Sien Lin, Xiaoyu Chen, more

Small > 14 > 7 > n/a - n/a

Targeted and sustained delivery of drugs to diseased tissues/organs, where body fluid exchange and catabolic activity are substantial, is challenging due to the fast cleansing and degradation of the drugs by these harsh environmental factors. Herein, a multifunctional and bioadhesive polycaprolactone‐β‐cyclodextrin (PCL‐CD) polymersome is developed for localized and sustained co‐delivery of hydrophilic...

article

Nanolayered hybrid mediates synergistic co-delivery of ligand and ligation activator for inducing stem cell differentiation and tissue healing

Heemin Kang, Minkyu Kim, Qian Feng, Sien Lin, more

Biomaterials > 2017 > 149 > C > 12-28

Cellular behaviors, such as differentiation, are regulated by complex ligation processes involving cell surface receptors, which can be activated by various divalent metal cations. The design of nanoparticle for co-delivery of ligand and ligation activator can offer a novel strategy to synergistically stimulate ligation processes in vivo. Here, we present a novel layered double hydroxide (LDH)-based...

article

Nanocomposite hydrogels stabilized by self-assembled multivalent bisphosphonate-magnesium nanoparticles mediate sustained release of magnesium ion and promote in-situ bone regeneration

Kunyu Zhang, Sien Lin, Qian Feng, Chaoqun Dong, more

Acta Biomaterialia > 2017 > 64 > C > 389-400

Hydrogels are appealing biomaterials for applications in regenerative medicine due to their tunable physical and bioactive properties. Meanwhile, therapeutic metal ions, such as magnesium ion (Mg²⁺), not only regulate the cellular behaviors but also stimulate local bone formation and healing. However, the effective delivery and tailored release of Mg²⁺ remains a challenge, with few reports on hydrogels...

article

Synergistic effects on mesenchymal stem cell-based cartilage regeneration by chondrogenic preconditioning and mechanical stimulation

Sien Lin, Wayne Yuk Wai Lee, Qian Feng, Liangliang Xu, more

Stem Cell Research & Therapy > 2017 > 8 > 1 > 1-12

Background Mesenchymal stem cells (MSCs) hold promising translational potential in cartilage regeneration. However, the efficacy of MSC-based tissue engineering is not satisfactory in the treatment of cartilage defect because of the inevitable cellular functional changes during ex vivo cell expansion. How to maintain the chondrogenic capacity of MSCs to improve their therapeutic outcomes remains an...

chapter

Analysis and prediction of team performance based on interaction networks

Sa Liu, Lin Wang, Sien Lin, Zhi Yang, more

2017 36th Chinese Control Conference (CCC) > 11250 - 11255

2017 36th Chinese Control Conference (CCC)

Quantifying team dynamics and predicting team performance in social physics have become increasingly important research problems. In this paper, the multi-model dataset of interaction networks about cooperating teams is collected through wearable sensing technologies, that allows gathering information on team performance and dynamics. Based on this dataset, the predictive power of team discussion...

article

Sulfated hyaluronic acid hydrogels with retarded degradation and enhanced growth factor retention promote hMSC chondrogenesis and articular cartilage integrity with reduced hypertrophy

Qian Feng, Sien Lin, Kunyu Zhang, Chaoqun Dong, more

Acta Biomaterialia > 2017 > 53 > C > 329-342

Recently, hyaluronic acid (HA) hydrogels have been extensively researched for delivering cells and drugs to repair damaged tissues, particularly articular cartilage. However, the in vivo degradation of HA is fast, thus limiting the clinical translation of HA hydrogels. Furthermore, HA cannot bind proteins with high affinity because of the lack of negatively charged sulfate groups. In this study, we...

article

Epigenetic Modification of the CCL5/CCR1/ERK Axis Enhances Glioma Targeting in Dedifferentiation-Reprogrammed BMSCs

Rui Chen, Wayne Yuk-Wai Lee, Xiao Hu Zhang, Jie Ting Zhang, more

Stem Cell Reports > 2017 > 8 > 3 > 743-757

The success of stem cell-mediated gene therapy in cancer treatment largely depends on the specific homing ability of stem cells. We have previously demonstrated that after in vitro induction of neuronal differentiation and dedifferentiation, bone marrow stromal cells (BMSCs) revert to a primitive stem cell population (De-neu-BMSCs) distinct from naive BMSCs. We report here that De-neu-BMSCs express...

article

Corrigendum to “Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration” [Biomaterials 101C (2016) 217–228]

Qian Feng, Kongchang Wei, Sien Lin, Zhen Xu, more

Biomaterials > 2017 > 112 > C > 346-347

article

Aspirin prevents bone loss with little mechanical improvement in high-fat-fed ovariectomized rats

Sien Lin, Wayne Y.W. Lee, Meiling Huang, Ziwei Fu, more

European Journal of Pharmacology > 2016 > 791 > C > 331-338

Obesity and osteoporosis are often concurrently happened in the menopausal women. Obesity in menopausal women is not only related to a high risk of cardiovascular disease, but also results in a detrimental effect on bone health. This study aimed to investigate the effects of aspirin, a popular anti-thrombosis drug, on bone quantity and quality in the high-fat-fed animal model. Adult female rats were...

article

Smad7 partially knockout mouse: a new animal model of osteoarthritis

Sien Lin, Wayne Yuk Wai Lee, Jinfang Zhang, Liao Cui, more

Journal of Orthopaedic Translation > 2016 > 7 > C > 92

article

Hydrothermally converted marine coral scaffold promotes segmental bone defect healing in rats

Sien Lin, Wayne Yuk Wai Lee, Yuxin Sun, Liao Cui, more

Journal of Orthopaedic Translation > 2016 > 7 > C > 79-80

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INFONA - science communication portal

Search results for: Sien Lin

Molecular Programming of NIR‐IIb‐Emissive Semiconducting Small Molecules for In Vivo High‐Contrast Bioimaging Beyond 1500 nm

Probing the role of methyl methacrylate release from spacer materials in induced membrane bone healing

Bone Imaging: Gold Nanoclusters for NIR‐II Fluorescence Imaging of Bones (Small 43/2020)

Gold Nanoclusters for NIR‐II Fluorescence Imaging of Bones

Asiatic Acid Attenuates Bone Loss by Regulating Osteoclastic Differentiation

Anisotropic Nanoscale Presentation of Cell Adhesion Ligand Enhances the Recruitment of Diverse Integrins in Adhesion Structures and Mechanosensing‐Dependent Differentiation of Stem Cells

Sox11-modified mesenchymal stem cells accelerate cartilage defect repair in SD rats

Remote Control of Intracellular Calcium Using Upconversion Nanotransducers Regulates Stem Cell Differentiation In Vivo

GPR120 is an important inflammatory regulator in the development of osteoarthritis

Bioadhesive Polymersome for Localized and Sustained Drug Delivery at Pathological Sites with Harsh Enzymatic and Fluidic Environment via Supramolecular Host–Guest Complexation

Nanolayered hybrid mediates synergistic co-delivery of ligand and ligation activator for inducing stem cell differentiation and tissue healing

Nanocomposite hydrogels stabilized by self-assembled multivalent bisphosphonate-magnesium nanoparticles mediate sustained release of magnesium ion and promote in-situ bone regeneration

Synergistic effects on mesenchymal stem cell-based cartilage regeneration by chondrogenic preconditioning and mechanical stimulation

Analysis and prediction of team performance based on interaction networks

Sulfated hyaluronic acid hydrogels with retarded degradation and enhanced growth factor retention promote hMSC chondrogenesis and articular cartilage integrity with reduced hypertrophy

Epigenetic Modification of the CCL5/CCR1/ERK Axis Enhances Glioma Targeting in Dedifferentiation-Reprogrammed BMSCs

Corrigendum to “Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration” [Biomaterials 101C (2016) 217–228]

Aspirin prevents bone loss with little mechanical improvement in high-fat-fed ovariectomized rats

Smad7 partially knockout mouse: a new animal model of osteoarthritis

Hydrothermally converted marine coral scaffold promotes segmental bone defect healing in rats

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