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The importance of the immediately releasable pool (IRP) of vesicles was proposed to reside in the maintenance of chromaffin cell secretion during the firing of action potentials at basal physiological frequencies. To accomplish this duty, IRP should be replenished as a function of time. We have previously reported that an action potential‐like stimulus (APls) triggers the release of ~50% IRP, followed...
As part of the search for effective cancer chemotherapy, we describe here the synthesis, characterization, structural determination and biological activity of a new copper complex [Cu{1-phenyl-2,5-bis(2-thienyl)phosphole}2Cl] (1), and evaluated its biological activity in terms of binding to calf thymus (CT) DNA, distribution coefficient, interaction with thioredoxin reductase (TrxR) and inhibition...
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