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This article highlights the role of psychiatric illness, mainly the affective disorders, in the work of famous painters throughout the centuries. Especially paintings from well-known artists such as Pieter Bruegel, Albrecht Dürer, Henri de Toulouse – Lautrec, Vincent van Gogh, Edward Munch, Ernst Ludwig Kirchner, Frida Kahlo and Lucian Freud are discussed in detail. While pain and disease are unavoidable...