Search results for: Tobias Carling

Items from 1 to 20 out of 51 results

article

Reply to “Differences in the Impact of Age on Mortality in Well-Differentiated Thyroid Cancer”

Norman G. Nicolson, Tobias Carling

Annals of Surgical Oncology > 2019 > 26 > 2 > 697-697

article

Clonal evolution analysis of paired anaplastic and well‐differentiated thyroid carcinomas reveals shared common ancestor

Weilai Dong, Norman G. Nicolson, Jungmin Choi, Andrea L. Barbieri, more

Genes, Chromosomes and Cancer > 57 > 12 > 645 - 652

Foci of papillary or follicular thyroid carcinoma are frequently noted in thyroidectomy specimens of anaplastic thyroid carcinoma (ATC). However, whether ATCs evolve from these co‐existing well‐differentiated thyroid carcinomas (WDTCs) has not been well‐understood. To investigate the progression of ATC in patients with co‐existing WDTCs, five ATC tumors with co‐existing WDTCs and matching normal tissues...

article

SLC12A7 alters adrenocortical carcinoma cell adhesion properties to promote an aggressive invasive behavior

Taylor C. Brown, Timothy D. Murtha, Jill C. Rubinstein, Reju Korah, more

Cell Communication and Signaling > 2018 > 16 > 1 > 1-13

Background Altered expression of Solute Carrier Family 12 Member 7 (SLC12A7) is implicated to promote malignant behavior in multiple cancer types through an incompletely understood mechanism. Recent studies have shown recurrent gene amplifications and overexpression of SLC12A7 in adrenocortical carcinoma (ACC). The potential mechanistic effect(s) of SLC12A7 amplifications in portending an aggressive...

article

DNA Mismatch Repair Deficiency Promotes Genomic Instability in a Subset of Papillary Thyroid Cancers

Mahsa Javid, Thanyawat Sasanakietkul, Norman G. Nicolson, Courtney E. Gibson, more

World Journal of Surgery > 2018 > 42 > 2 > 358-366

Background Efficient DNA damage repair by MutL-homolog DNA mismatch repair (MMR) enzymes, MLH1, MLH3, PMS1 and PMS2, are required to maintain thyrocyte genomic integrity. We hypothesized that persistent oxidative stress and consequent transcriptional dysregulation observed in thyroid follicles will lead to MMR deficiency and potentiate papillary thyroid tumorigenesis. Methods MMR gene expression...

article

Overexpression of cytochrome P450 2A6 in adrenocortical carcinoma

Timothy D. Murtha, Taylor C. Brown, Jill C. Rubinstein, Felix Haglund, more

Surgery > 2017 > 161 > 6 > 1667-1674

Cytochrome P450-mediated metabolism of chemotherapeutic agents contributes to chemotherapy resistance in multiple malignancies. Adrenocortical carcinoma is known to have a poor response to adjuvant therapies; however, the mechanism remains unknown. Recent comprehensive genetic analyses of adrenocortical carcinomas demonstrated recurrent copy number gains in multiple cytochrome P450 genes prompting...

article

Primary hyperparathyroidism treated by transoral endoscopic parathyroidectomy vestibular approach (TOEPVA)

Thanyawat Sasanakietkul, Tobias Carling

Surgical Endoscopy > 2017 > 31 > 11 > 4832-4833

Background Bilateral open cervical exploration with identifying all parathyroid glands and removing one or more enlarged parathyroid tumor(s) was the standard of care in primary hyperparathyroidism (pHPT). With the introduction of preoperative imaging and intraoperative parathyroid hormone (IOPTH) measurements [1, 2], various minimally invasive parathyroidectomy approaches have been developed, both...

article

A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis

Joyce Y. Cheng, Taylor C. Brown, Timothy D. Murtha, Adam Stenman, more

BMC Cancer > 2017 > 17 > 1 > 1-13

Background Dysregulated WNT signaling dominates adrenocortical malignancies. This study investigates whether silencing of the WNT negative regulator DKK3 (Dickkopf-related protein 3), an implicated adrenocortical differentiation marker and an established tumor suppressor in multiple cancers, allows dedifferentiation of the adrenal cortex. Methods We analyzed the expression and regulation of DKK3...

article

Primary hyperparathyroidism with normal baseline intraoperative parathyroid hormone: A challenging population

Mahsa Javid, Glenda Callender, Courtney Quinn, Tobias Carling, more

Surgery > 2017 > 161 > 2 > 493-498

Patients with primary hyperparathyroidism and baseline intraoperative parathyroid hormone levels in the normal range are challenging. This study compares the predictive value of a commonly used intraoperative parathyroid hormone algorithm, a software model for cure prediction, and surgeon judgment in this population.This was a retrospective review of consecutive patients who underwent parathyroidectomy...

article

Suppression of cytochrome P450 4B1: An early event in adrenocortical tumorigenesis

Timothy D. Murtha, Reju Korah, Tobias Carling

Surgery > 2017 > 161 > 1 > 257-263

Adrenocortical carcinoma is a rare neoplasm with a poor prognosis. Conversely, adrenocortical adenomas are common and benign. Despite their shared histologic origin, little evidence exists to suggest that adrenocortical adenoma arises from adrenocortical carcinoma. Recent genetic analyses of adrenocortical carcinoma have shown recurrent gene copy deletion of CYP4B1, a cytochrome P450 isozyme. This...

article

Parathyroidectomy prior to kidney transplant decreases graft failure

Glenda G. Callender, Jennifer Malinowski, Mahsa Javid, Yawei Zhang, more

Surgery > 2017 > 161 > 1 > 44-50

Uncorrected uremic hyperparathyroidism is associated with delayed graft function after kidney transplantation. The current guidelines of the Kidney Disease Improving Global Outcomes recommend maintaining parathyroid hormone ≤9x normal in patients pre–kidney transplantation. This study explores the effect of increased levels of serum parathyroid hormone and preoperative parathyroidectomy on outcomes...

article

Dissection of Levels II Through V Is Required for Optimal Outcomes in Patients with Lateral Neck Lymph Node Metastasis from Papillary Thyroid Carcinoma

Mahsa Javid, Emma Graham, Jennifer Malinowski, Courtney E. Quinn, more

Journal of the American College of Surgeons > 2016 > 222 > 6 > 1066-1073

Completeness of surgical resection is an important determinant of outcomes in patients with papillary thyroid carcinoma and regional lymph node metastasis. The extent of therapeutic lateral neck dissection remains controversial. This study aims to assess the impact of modified radical neck dissection of levels II to V in a large patient series.Retrospective analysis of consecutive patients with papillary...

article

Absence of KMT2D/MLL2 mutations in abdominal paraganglioma

Adam Stenman, Carl C. Juhlin, Felix Haglund, Taylor C. Brown, more

Clinical Endocrinology > 84 > 4 > 632 - 634

chapter

Adrenal Tumors in Older Persons

Tobias Carling, Robert Udelsman

Principles and Practice of Geriatric Surgery > Endocrine System/Breast > 455-467

Adrenal tumors are common, especially in older individuals. Numerous autopsy studies have examined the frequency of adrenal tumors, and in a review of 87,065 autopsies, adrenal lesions (>1 cm) were identified in 6% of patients [1]. Similarly, the prevalence of adrenal “incidentalomas” is 4% when detected by abdominal CT or magnetic resonance imaging (MRI). The incidence of adrenal tumors increases...

article

Chromosome 19 amplification correlates with advanced disease in adrenocortical carcinoma

Jill C. Rubinstein, Taylor C. Brown, Gerald Goh, C. Christofer Juhlin, more

Surgery > 2016 > 159 > 1 > 296-301

Familial syndromes with specific genetic drivers account for a subset of adrenocortical carcinomas (ACCs), but the genomic underpinnings of sporadic cases remain poorly understood. Recent advances in copy number variation (CNV) prediction from exome sequencing are facilitating exploration of genomic rearrangements common to these carcinomas.ACC and matched, nontumor samples underwent exome sequencing...

article

DNA copy amplification and overexpression of SLC12A7 in adrenocortical carcinoma

Taylor C. Brown, C. Christofer Juhlin, James M. Healy, Adam Stenman, more

Surgery > 2016 > 159 > 1 > 250-258

Overexpression of Solute carrier family 12 member 7 (SLC12A7) promotes tumor aggressiveness in various cancers. Previous studies have identified the 5p15.33 region, containing the SLC12A7 locus, as being amplified frequently in adrenocortical carcinoma (ACC). Copy number amplifications (CNAs) may alter gene expression levels and occur frequently in ACC; however, SLC12A7 gene amplifications or expression...

article

Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma

Jill C. Rubinstein, Taylor C. Brown, Emily R. Christison-Lagay, Yawei Zhang, more

BMC Cancer > 2016 > 16 > 1 > 1-9

Background Cancer is increasingly understood to arise in the context of dynamically evolving genomes with continuously generated variants subject to selective pressures. Diverse mutations have been identified in papillary thyroid carcinoma (PTC), but unifying theories underlying genomic change are lacking. Applying a framework of somatic evolution, we sought to broaden understanding of the PTC genome...

article

Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype

Ute I. Scholl, James M. Healy, Anne Thiel, Annabelle L. Fonseca, more

Clinical Endocrinology > 83 > 6 > 779 - 789

Aldosterone‐producing adenomas (APAs) and bilateral adrenal hyperplasia are important causes of secondary hypertension. Somatic mutations in KCNJ5, CACNA1D, ATP1A1, ATP2B3 and CTNNB1 have been described in APAs. Objective To characterize clinical–pathological features in APAs and unilateral adrenal hyperplasia, and correlate them with genotypes. Design Retrospective study. Subjects and Measurements...

article

Whole‐exome sequencing defines the mutational landscape of pheochromocytoma and identifies KMT2D as a recurrently mutated gene

C. Christofer Juhlin, Adam Stenman, Felix Haglund, Victoria E. Clark, more

Genes, Chromosomes and Cancer > 54 > 9 > 542 - 554

As subsets of pheochromocytomas (PCCs) lack a defined molecular etiology, we sought to characterize the mutational landscape of PCCs to identify novel gene candidates involved in disease development. A discovery cohort of 15 PCCs wild type for mutations in PCC susceptibility genes underwent whole‐exome sequencing, and an additional 83 PCCs served as a verification cohort for targeted sequencing of...

article

Modern Experience with Aggressive Parathyroid Tumors in a High-Volume New England Referral Center

Courtney E. Quinn, James Healy, Amir H. Lebastchi, Taylor C. Brown, more

Journal of the American College of Surgeons > 2015 > 220 > 6 > 1054-1062

Parathyroid carcinoma (PTCA) is an exceptionally rare malignancy, often with a clinical presentation similar to that of benign atypical parathyroid adenoma. Its low incidence portends unclear guidelines for management. Accordingly, thorough examination of clinical and pathologic variables was undertaken to distinguish between PTCA and atypical adenomas.This was a retrospective analysis of a prospective...

article

Real-Time Super Selective Venous Sampling in Remedial Parathyroid Surgery

Amir H. Lebastchi, John E. Aruny, Patricia I. Donovan, Courtney E. Quinn, more

Journal of the American College of Surgeons > 2015 > 220 > 6 > 994-1000

Remedial cervical exploration for persistent or recurrent primary hyperparathyroidism can be technically difficult, but is expedited by accurate preoperative localization. We investigated the use of real-time super selective venous sampling (sSVS) in the setting of negative noninvasive imaging modalities.We performed a retrospective analysis of a prospective database incorporating real-time sSVS in...

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INFONA - science communication portal

Search results for: Tobias Carling

Reply to “Differences in the Impact of Age on Mortality in Well-Differentiated Thyroid Cancer”

Clonal evolution analysis of paired anaplastic and well‐differentiated thyroid carcinomas reveals shared common ancestor

SLC12A7 alters adrenocortical carcinoma cell adhesion properties to promote an aggressive invasive behavior

DNA Mismatch Repair Deficiency Promotes Genomic Instability in a Subset of Papillary Thyroid Cancers

Overexpression of cytochrome P450 2A6 in adrenocortical carcinoma

Primary hyperparathyroidism treated by transoral endoscopic parathyroidectomy vestibular approach (TOEPVA)

A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis

Primary hyperparathyroidism with normal baseline intraoperative parathyroid hormone: A challenging population

Suppression of cytochrome P450 4B1: An early event in adrenocortical tumorigenesis

Parathyroidectomy prior to kidney transplant decreases graft failure

Dissection of Levels II Through V Is Required for Optimal Outcomes in Patients with Lateral Neck Lymph Node Metastasis from Papillary Thyroid Carcinoma

Absence of KMT2D/MLL2 mutations in abdominal paraganglioma

Adrenal Tumors in Older Persons

Chromosome 19 amplification correlates with advanced disease in adrenocortical carcinoma

DNA copy amplification and overexpression of SLC12A7 in adrenocortical carcinoma

Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma

Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype

Whole‐exome sequencing defines the mutational landscape of pheochromocytoma and identifies KMT2D as a recurrently mutated gene

Modern Experience with Aggressive Parathyroid Tumors in a High-Volume New England Referral Center

Real-Time Super Selective Venous Sampling in Remedial Parathyroid Surgery

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