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Background: Reboxetine is a potent antidepressant, with efficacy comparable to that of imipramine, desipramine, and fluoxetine, and has improved side-effect profile. The basis of its efficacy and improved tolerability is sought through studies of reboxetine in a number of pharmacological models of depression.Methods: Pharmacological selectivity for uptake systems was defined by uptake and binding...
• ■ Objective: To determine whether the phosphate binder calcium carbonate is effective in preventing hyperphosphatemia in dialysis patients when administered between meals as well as with meals. • ■ Design: An open-label, nonrandomized, cross-over study. • ■ Setting: Three hemodialysis centers where staff is experienced in the conduct of clinical trials. • ■ Patients: Clinically stable adult patients...
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