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We hypothesized that hypoventilation induced by resistive loaded breathing may result in part from an increase in γ-aminobutyric acid (GABA) concentration in the central nervous system. Accordingly, ventilatory depression should be minimized by GABA receptor blockade. The effects of subseizure doses of the GABA A receptor antagonist bicuculline on the cardiorespiratory variables and cortical...
It was previously shown that inspiratory resistive loading (IRL) increases the cerebrospinal fluid (CSF) level of beta endorphin in awake goats, and also that the slower ventilation induced by injection of this substance into the CSF of anesthetized dogs is suppressed after vagotomy. In the present study, performed on anesthetized rabbits, we evaluated the part played by vagal afferents in the ventilatory...
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