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Depuis une vingtaine d’années, le développement de nanoparticules comprenant des éléments de haut numéro atomique comme agents radiosensibilisants est en plein essor. Le design de ces nano-objets doit respecter les contraintes « classiques » liées au développement de nanoparticules pour une application en oncologie, tout en permettant d’augmenter l’effet de la dose locale dans la zone tumorale en...
The aim of this study is to quantify and to compare the dose enhancement factor from gold nanoparticles (AuNP) to tumor endothelial cells for different concentrations of AuNP, and clinical MV beam configurations.Tumor endothelial cells are modeled as slabs measuring 10 × 10 × 2 lm. A spherical AuNP is simulated on the surface of the endothelial cell, within the blood vessel. 6 MV photon beams with...
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