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Eukaryotic genomes are packaged into a 3-dimensional structure in the nucleus. Current methods for studying genome-wide structure are based on proximity ligation. However, this approach can fail to detect known structures, such as interactions with nuclear bodies, because these DNA regions can be too far apart to directly ligate. Accordingly, our overall understanding of genome organization remains...
Deriving phylogeny of rapidly evolving viral genomes is one of the most challenging problems in evolutionary studies since gene-based phylogenies often produce conflicting evolutionary trees. Phylogenetic reconstruction methods that consider whole genomes are becoming more reliable with the increasing availability of complete genome sequences and the development of algorithms to compare entire genomes...
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