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Malaria is one of the world's serious diseases causing death of about half a million people in 2015. The protozoan Plasmodium Falciparum inflicts the most damage and is responsible for most malaria related deaths. Biomedical research could enable treating the disease by effectively and specifically targeting essential enzymes of this parasite. However, the parasite has developed resistance to existing...
Background Simulating protein folding motions is an important problem in computational biology. Motion planning algorithms, such as Probabilistic Roadmap Methods, have been successful in modeling the folding landscape. Probabilistic Roadmap Methods and variants contain several phases (i.e., sampling, connection, and path extraction). Most of the time is spent in the connection phase and selecting...
Motivation: Simulating protein folding motions is an important problem in computational biology. Motion planning algorithms such as Probabilistic Roadmap Methods (PRMs) have been successful in modeling the protein folding landscape. PRMs and variants contain several phases (i.e., sampling, connection, and path extraction). Global machine learning has been applied to the connection phase but is inefficient...
Probabilistic Roadmap Methods (PRMs) solve the motion planing problem by constructing a roadmap (or graph) that models the motion space when feasible local motions exist. PRMs and variants contain several phases during roadmap generation i.e., sampling, connection, and query. Some work has been done to apply machine learning to the connection phase to decide which variant to employ, but it uses a...
Probabilistic Roadmap Methods (PRMs) are widely used motion planning methods that sample robot configurations (nodes) and connect them to form a graph (roadmap) containing feasible trajectories. Many PRM variants propose different strategies for each of the steps and choosing among them is problem dependent. Planning in heterogeneous environments and/or on parallel machines necessitates dividing the...
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