Search results for: Daniel P. Beavers

Items from 1 to 20 out of 28 results

article

Clinical, Health‐Related Quality of Life, and Gait Differences Among Obesity Classes in Adults With Knee Osteoarthritis

Stephen P. Messier, Malia E. Gill, Shannon L. Mihalko, Daniel P. Beavers, more

Arthritis Care & Research > 76 > 4 > 503 - 510

Objective The purpose of this study was to determine whether clinical, health‐related quality of life (HRQL), and gait characteristics in adults with knee osteoarthritis (OA) differed by obesity category. Methods This cross‐sectional analysis of 823 older adults (mean age 64.6 years, SD 7.8 years) with knee OA and overweight or obesity compared clinical, HRQL, and gait outcomes among obesity classifications...

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Changes in Body Weight and Knee Pain in Adults With Knee Osteoarthritis Three‐and‐a‐Half Years After Completing Diet and Exercise Interventions: Follow‐Up Study for a Single‐Blind, Single‐Center, Randomized Controlled Trial

Stephen P. Messier, Jovita J. Newman, Matthew J. Scarlett, Shannon L. Mihalko, more

Arthritis Care & Research > 74 > 4 > 607 - 616

Objective To determine whether long‐term diet (D) and exercise (E) interventions, alone or in combination (D+E), have beneficial effects for older adults with knee osteoarthritis (OA) 3.5 years after the interventions end. Methods This is a secondary analysis of a subset (n = 94) of the first 184 participants who had successfully completed the Intensive Diet and Exercise in Arthritis (IDEA) trial...

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Risedronate use to attenuate bone loss following sleeve gastrectomy: Results from a pilot randomized controlled trial

Kristen M. Beavers, Daniel P. Beavers, Adolfo Z. Fernandez, Katelyn A. Greene, more

Clinical Obesity > 11 > 6 > n/a - n/a

The purpose of this study was to explore the efficacy of 150 mg once monthly oral risedronate use in the prevention of sleeve gastrectomy (SG) associated bone loss. Twenty‐four SG patients (56 ± 7 years, 83% female, 21% black) were randomized to risedronate or placebo for 6 months, with an optional 12‐month assessment. Outcome measures included 6 (n = 21) and 12 (n = 14) month change in dual energy...

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Precision Medicine Approach to Develop and Internally Validate Optimal Exercise and Weight‐Loss Treatments for Overweight and Obese Adults With Knee Osteoarthritis: Data From a Single‐Center Randomized Trial

Xiaotong Jiang, Amanda E. Nelson, Rebecca J. Cleveland, Daniel P. Beavers, more

Arthritis Care & Research > 73 > 5 > 693 - 701

Objective To apply a precision medicine approach to determine the optimal treatment regime for participants in an exercise (E), dietary weight loss (D), and D + E trial for knee osteoarthritis that would maximize their expected outcomes. Methods Using data from 343 participants of the Intensive Diet and Exercise for Arthritis (IDEA) trial, we applied 24 machine‐learning models to develop individualized...

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Air Pollution and the Dynamic Association Between Depressive Symptoms and Memory in Oldest‐Old Women

Andrew J. Petkus, Diana Younan, Xinhui Wang, Daniel P. Beavers, more

Journal of the American Geriatrics Society > 69 > 2 > 474 - 484

BACKGROUND/OBJECTIVES Exposure to air pollution may contribute to both increasing depressive symptoms and decreasing episodic memory in older adulthood, but few studies have examined this hypothesis in a longitudinal context. Accordingly, we examined the association between air pollution and changes in depressive symptoms (DS) and episodic memory (EM) and their interrelationship in oldest‐old (aged...

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Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability

Nancy W. Glynn, Theresa Gmelin, Adam J. Santanasto, Laura C. Lovato, more

Journal of the American Geriatrics Society > 68 > 3 > 619 - 624

OBJECTIVES Our aim was to examine the impacts of baseline fatigue on the effectiveness of a physical activity (PA) intervention to prevent major mobility disability (MMD) and persistent major mobility disability (PMMD) in participants from the Lifestyle Interventions and Independence for Elders (LIFE) study. DESIGN Prospective cohort of individuals aged 65 years or older undergoing structured PA...

article

Dementia outcomes after addition of proxy‐based assessments for deceased or proxy‐dependent participants

Sarah A. Gaussoin, Mark A. Espeland, Daniel P. Beavers, Ramon Casanova, more

International Journal of Geriatric Psychiatry > 34 > 10 > 1403 - 1411

Objectives As people age and the incidence of dementia increases, studies of cognitive function continue to be of importance. Ascertaining cognitive data through different mechanisms is necessary to address missing data concerns. Methods The Dementia Questionnaire (DQ), which utilizes proxy‐based assessments, is a potential tool to determine cognitive status in participants no longer being followed...

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Intentional Weight Loss in Overweight and Obese Patients With Knee Osteoarthritis: Is More Better?

Stephen P. Messier, Allison E. Resnik, Daniel P. Beavers, Shannon L. Mihalko, more

Arthritis Care & Research > 70 > 11 > 1569 - 1575

Objective To determine the dose response effect of weight loss on clinical and mechanistic outcomes in overweight and obese adults with knee osteoarthritis (OA). Methods This is a secondary analysis of the diet‐induced weight loss only (D) and diet‐induced weight loss plus exercise (D + E) groups in the Intensive Diet and Exercise for Arthritis randomized controlled clinical trial. The 240 participants...

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Prediction of lumbar vertebral body compressive strength of overweight and obese older adults using morphed subject-specific finite-element models to evaluate the effects of weight loss

Samantha L. Schoell, Kristen M. Beavers, Daniel P. Beavers, Leon Lenchik, more

Aging Clinical and Experimental Research > 2019 > 31 > 4 > 491-501

Background Diet and exercise can promote weight loss in older adults; however, there is potential to increase fracture risk due to loss of bone mineral density (BMD) known to accompany weight loss. Weight loss effects on measures of bone quality and strength are currently unknown. Aims The purpose of this study is to develop subject-specific finite-element (FE) models of the lumbar spine and study...

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The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study

Kathleen M. Hayden, Daniel P. Beavers, Susan E. Steck, James R. Hebert, more

Alzheimer's & Dementia > 2017 > 13 > 11 > 1187-1196

The Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation to mild cognitive impairment (MCI)/dementia risk.Baseline food frequency questionnaires from n = 7085 women (aged 65–79 years) were used to calculate Dietary Inflammatory Index (DII) scores that were categorized into four groups...

article

ENabling Reduction of Low‐grade Inflammation in SEniors Pilot Study: Concept, Rationale, and Design

Todd M. Manini, Stephen D. Anton, Daniel P. Beavers, Jane A. Cauley, more

Journal of the American Geriatrics Society > 65 > 9 > 1961 - 1968

Objectives To test two interventions to reduce interleukin (IL)‐6 levels, an indicator of low‐grade chronic inflammation and an independent risk factor for impaired mobility and slow walking speed in older adults. Design The ENabling Reduction of low‐Grade Inflammation in SEniors (ENRGISE) Pilot Study was a multicenter, double‐blind, placebo‐controlled randomized pilot trial of two interventions...

article

Effect of Physical Activity on Self‐Reported Disability in Older Adults: Results from the LIFE Study

Todd M. Manini, Daniel P. Beavers, Marco Pahor, Jack M. Guralnik, more

Journal of the American Geriatrics Society > 65 > 5 > 980 - 988

Background/Objectives To test the hypothesis that a long‐term structured, moderate intensity physical activity (PA) program is more effective than a health education (HE) program in reducing the risk of s elf‐reported dependency and disability in basic activities of daily living (BADLs), disability in instrumental ADLs (IADL), and mobility disability. Design The Lifestyle Interventions and Independence...

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Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study

Mylène Aubertin-Leheudre, Stephen Anton, Daniel P. Beavers, Todd M. Manini, more

Journal of the American Medical Directors Association > 2017 > 18 > 4 > 312-319

The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults.A total of 1453 men and women (age ≥70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese...

article

The effect of intervening hospitalizations on the benefit of structured physical activity in promoting independent mobility among community-living older persons: secondary analysis of a randomized controlled trial

Thomas M. Gill, Daniel P. Beavers, Jack M. Guralnik, Marco Pahor, more

BMC Medicine > 2017 > 15 > 1 > 1-13

Background Among older persons, disability is often precipitated by intervening illnesses and injuries leading to hospitalization. In the Lifestyle Interventions and Independence for Elders (LIFE) Study, a structured moderate-intensity physical activity program, compared with a health education program, was shown to significantly reduce the amount of time spent with major mobility disability (MMD)...

article

Weight-loss and exercise for communities with arthritis in North Carolina (we-can): design and rationale of a pragmatic, assessor-blinded, randomized controlled trial

Stephen P. Messier, Leigh F. Callahan, Daniel P. Beavers, Kate Queen, more

BMC Musculoskeletal Disorders > 2017 > 18 > 1 > 1-14

Background Recently, we determined that in a rigorously monitored environment an intensive diet-induced weight loss of 10% combined with exercise was significantly more effective at reducing pain in men and women with symptomatic knee osteoarthritis (OA) than either intervention alone. Compared to previous long-term weight loss and exercise trials of knee OA, our intensive diet-induced weight loss...

article

Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study

Andrew S. Layne, Fang-Chi Hsu, Steven N. Blair, Shyh-Huei Chen, more

Archives of Physical Medicine and Rehabilitation > 2017 > 98 > 1 > 11-24.e3

To evaluate the extent of variability in functional responses in participants in the Lifestyle Interventions and Independence for Elders (LIFE) study and to identify the relative contributions of intervention adherence, physical activity, and demographic and health characteristics to this variability.Secondary analysis.Multicenter institutions.A volunteer sample (N=1635) of sedentary men and women...

article

Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial

Anthony P. Marsh, William B. Applegate, Jack M. Guralnik, W. Jack Rejeski, more

Journal of the American Geriatrics Society > 64 > 5 > 933 - 943

Objectives To determine whether moderate‐intensity physical activity (PA) and health education (HE) are differentially associated with categories of hospitalizations or subgroups of participants. Design Multicenter randomized controlled trial in which participants were randomized to a PA or HE program for an average of 2.6 years. Setting Eight field centers. Participants Sedentary men and women...

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Effect of Structured Physical Activity on Respiratory Outcomes in Sedentary Elderly Adults with Mobility Limitations

Carlos A. Vaz Fragoso, Daniel P. Beavers, Stephen D. Anton, Christine K. Liu, more

Journal of the American Geriatrics Society > 64 > 3 > 501 - 509

ObjectivesTo evaluate the effect of structured physical activity on respiratory outcomes in community‐dwelling elderly adults with mobility limitations. DesignMulticenter, randomized trial of physical activity vs health education, with respiratory variables prespecified as tertiary outcomes over an intervention period of 24–42 months. Physical activity included walking (goal of 150 min/week) and...

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Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations — The LIFE Study

Robert T. Mankowski, Mylene Aubertin-Leheudre, Daniel P. Beavers, Anda Botoseneanu, more

Experimental Gerontology > 2015 > 70 > Complete > 32-36

Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults.The association between objectively measured sedentary time (accelerometry) with MetS and MetS components...

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Prevalence of Metabolic Syndrome and Its Association with Physical Capacity, Disability, and Self‐Rated Health in Lifestyle Interventions and Independence for Elders Study Participants

Anda Botoseneanu, Walter T. Ambrosius, Daniel P. Beavers, Nathalie Rekeneire, more

Journal of the American Geriatrics Society > 63 > 2 > 222 - 232

ObjectivesTo evaluate the prevalence of metabolic syndrome (MetS) and its association with physical capacity, disability, and self‐rated health in older adults at high risk of mobility disability, including those with and without diabetes mellitus. DesignCross‐sectional analysis. SettingLifestyle Interventions and Independence for Elders (LIFE) Study. ParticipantsCommunity‐dwelling sedentary adults...

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INFONA - science communication portal

Search results for: Daniel P. Beavers

Clinical, Health‐Related Quality of Life, and Gait Differences Among Obesity Classes in Adults With Knee Osteoarthritis

Changes in Body Weight and Knee Pain in Adults With Knee Osteoarthritis Three‐and‐a‐Half Years After Completing Diet and Exercise Interventions: Follow‐Up Study for a Single‐Blind, Single‐Center, Randomized Controlled Trial

Risedronate use to attenuate bone loss following sleeve gastrectomy: Results from a pilot randomized controlled trial

Precision Medicine Approach to Develop and Internally Validate Optimal Exercise and Weight‐Loss Treatments for Overweight and Obese Adults With Knee Osteoarthritis: Data From a Single‐Center Randomized Trial

Air Pollution and the Dynamic Association Between Depressive Symptoms and Memory in Oldest‐Old Women

Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability

Dementia outcomes after addition of proxy‐based assessments for deceased or proxy‐dependent participants

Intentional Weight Loss in Overweight and Obese Patients With Knee Osteoarthritis: Is More Better?

Prediction of lumbar vertebral body compressive strength of overweight and obese older adults using morphed subject-specific finite-element models to evaluate the effects of weight loss

The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study

ENabling Reduction of Low‐grade Inflammation in SEniors Pilot Study: Concept, Rationale, and Design

Effect of Physical Activity on Self‐Reported Disability in Older Adults: Results from the LIFE Study

Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study

The effect of intervening hospitalizations on the benefit of structured physical activity in promoting independent mobility among community-living older persons: secondary analysis of a randomized controlled trial

Weight-loss and exercise for communities with arthritis in North Carolina (we-can): design and rationale of a pragmatic, assessor-blinded, randomized controlled trial

Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study

Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial

Effect of Structured Physical Activity on Respiratory Outcomes in Sedentary Elderly Adults with Mobility Limitations

Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations — The LIFE Study

Prevalence of Metabolic Syndrome and Its Association with Physical Capacity, Disability, and Self‐Rated Health in Lifestyle Interventions and Independence for Elders Study Participants

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