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Problem gelöst: C‐terminale Peptidalkohole können mit der konventionellen Festphasenpeptidsynthese (SPPS) nicht synthetisiert werden, weil sie über keine freie Carboxygruppe für das Anbinden an das Harz verfügen. Hilfe brachte das Anbinden eines β‐Aminoalkoholrests an das Harz als Startpunkt für die SPPS. Eine intramolekulare O‐N‐Acylwanderung vervollständigte die Synthese der gewünschten Peptide...
Getting the better of troublemakers: C‐terminal peptide alcohols cannot be synthesized by conventional solid‐phase peptide synthesis (SPPS) because of the absence of a free carboxylic group to attach to the resin. This problem was circumvented by anchoring a β‐amino alcohol residue to the resin to provide a starting point for SPPS. An intramolecular O–N acyl shift completed the synthesis of the desired...
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