Maosong Qiu

article

Monitoring ROS Responsive Fe₃O₄‐based Nanoparticle Mediated Ferroptosis and Immunotherapy via ¹²⁹Xe MRI

Lei Zhang, Maosong Qiu, Ruifang Wang, Sha Li, more

Angewandte Chemie > 136 > 22 > n/a - n/a

The immune checkpoint blockade strategy has improved the survival rate of late‐stage lung cancer patients. However, the low immune response rate limits the immunotherapy efficiency. Here, we report a ROS‐responsive Fe₃O₄‐based nanoparticle that undergoes charge reversal and disassembly in the tumor microenvironment, enhancing the uptake of Fe₃O₄ by tumor cells and triggering a more severe ferroptosis...

article

Monitoring ROS Responsive Fe₃O₄‐based Nanoparticle Mediated Ferroptosis and Immunotherapy via ¹²⁹Xe MRI

Lei Zhang, Maosong Qiu, Ruifang Wang, Sha Li, more

Angewandte Chemie International Edition > 63 > 22 > n/a - n/a

The immune checkpoint blockade strategy has improved the survival rate of late‐stage lung cancer patients. However, the low immune response rate limits the immunotherapy efficiency. Here, we report a ROS‐responsive Fe₃O₄‐based nanoparticle that undergoes charge reversal and disassembly in the tumor microenvironment, enhancing the uptake of Fe₃O₄ by tumor cells and triggering a more severe ferroptosis...

article

Augmenting Immunotherapy via Bioinspired MOF‐Based ROS Homeostasis Disruptor with Nanozyme‐Cascade Reaction

Ruifang Wang, Maosong Qiu, Lei Zhang, Meiju Sui, more

Advanced Materials > 35 > 49 > n/a - n/a

Despite its remarkable clinical breakthroughs, immune checkpoint blockade (ICB) therapy remains limited by the insufficient immune response in the “cold” tumor. Nanozyme‐based antitumor catalysis is associated with precise immune activation in the tumor microenvironment (TME). In this study, a cascade‐augmented nanoimmunomodulator (CMZM) with multienzyme‐like activities, which includes superoxide...

article

Innenrücktitelbild: In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent ¹⁹F NMR (Angew. Chem. 50/2022)

Shizhen Chen, Long Xiao, Yu Li, Maosong Qiu, more

Angewandte Chemie > 134 > 50 > n/a - n/a

Eine bimodale Bildgebungssonde FCy7‐NO₂ wurde eingesetzt, um die bei Lungenkrebs überexprimierte Nitroreduktase in vivo abzubilden, wie Xin Zhou et al. in ihrem Forschungsartikel berichten (e202213495). Die Integration zweier komplementärer Bildgebungstechnologien in FCy7‐NO₂ ermöglicht einen empfindlichen Nachweis von Nitroreduktase in einem breiten Konzentrationsbereich ohne Gewebetiefenbegrenzung...

article

Inside Back Cover: In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent ¹⁹F NMR (Angew. Chem. Int. Ed. 50/2022)

Shizhen Chen, Long Xiao, Yu Li, Maosong Qiu, more

Angewandte Chemie International Edition > 61 > 50 > n/a - n/a

A bimodal imaging probe FCy7‐NO₂ was applied to image nitroreductase overexpressed by lung cancer in vivo, as reported by Xin Zhou and co‐workers in their Research Article (e202213495). Integrating two complementary imaging technologies into FCy7‐NO₂ enables sensitive detection of nitroreductase over a broad concentration range without tissue‐depth limit.

article

In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent ¹⁹F NMR

Shizhen Chen, Long Xiao, Yu Li, Maosong Qiu, more

Angewandte Chemie > 134 > 50 > n/a - n/a

Nitroreductase (NTR) is an important biomarker widely used to evaluate the degree of tumor hypoxia. Although a few optical methods have been reported for detecting nitroreductase at low concentration ranges, an effective strategy for nitroreductase monitoring in vivo without limits to the imaging depth is still lacking. Herein, a novel dual‐mode NIR fluorescence and ¹⁹F MRI agent, FCy7‐NO₂, is proposed...

article

In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent ¹⁹F NMR

Shizhen Chen, Long Xiao, Yu Li, Maosong Qiu, more

Angewandte Chemie International Edition > 61 > 50 > n/a - n/a

Nitroreductase (NTR) is an important biomarker widely used to evaluate the degree of tumor hypoxia. Although a few optical methods have been reported for detecting nitroreductase at low concentration ranges, an effective strategy for nitroreductase monitoring in vivo without limits to the imaging depth is still lacking. Herein, a novel dual‐mode NIR fluorescence and ¹⁹F MRI agent, FCy7‐NO₂, is proposed...

article

Simultaneous Qualitative and Quantitative Analyses of Triterpenoids in Ilex pubescens by Ultra‐High‐Performance Liquid Chromatography Coupled with Quadrupole Time‐of‐Flight Mass Spectrometry

Di Cao, Qing Wang, Jing Jin, Maosong Qiu, more

Phytochemical Analysis > 29 > 2 > 168 - 179

Introduction Ilex pubescens Hook et Arn mainly contains triterpenoids that possess antithrombotic, anti‐inflammatory and analgesic effects. Quantitative and qualitative analyses of the triterpenoids in I. pubescens can be useful for determining the authenticity and quality of raw materials and guiding its clinical preparation. Objectives To establish a method for rapid and comprehensive analysis...

article

Diterpenoids from Croton crassifolius include a novel skeleton possibly generated via an intramolecular [2+2]-photocycloaddition reaction

Maosong Qiu, Jing Jin, Lian Zhou, Wen Zhou, more

Phytochemistry > 2018 > 145 > C > 103-110

Five previously undescribed terpenoids (cracrosons D-H), including three clerodane diterpenoids, together with 16 known diterpenoids were isolated from Croton crassifolius (Euphorbiaceae). Cracroson D features a previously undescribed carbon skeleton with an unprecedented cyclobutane ring. Their structures, including their absolute configurations, were elucidated using spectroscopic and single-crystal...

article

Two new hydroxylated ent-kauranoic acids from Pteris semipinnata

Maosong Qiu, Bao Yang, Di Cao, Jinping Zhu, more

Phytochemistry Letters > 2016 > 16 > C > 156-162

Two new hydroxylated ent-kauranoic acids, pterisolic acid G (1) and pterisolic acid H (3), together with five known ent-kaurane-type diterpenoids (2 and 4–7) were isolated from the whole plant of Pteris semipinnata L. The structures of compounds 1–3 were elucidated on the basis of HR-MS, 1D and 2D NMR analysis, and the absolute configuration of compounds 1 and 2 were determined by the results of single...

article

New clerodane diterpenoids from Croton crassifolius

Maosong Qiu, Di Cao, Youheng Gao, Shuhua Li, more

Fitoterapia > 2016 > 108 > Complete > 81-86

Two new clerodane diterpenoids (1–2), one new clerodane diterpenoid alkaloid (3), as well as thirteen known compounds were isolated from Croton crassifolius. The structures of new compounds were established by a combination of spectroscopic methods, including HRMS, ¹H NMR, ¹³C NMR, ¹H ¹H COSY, HSQC, HMBC, NOESY and X-ray crystallographic analysis. Compound 3 is firstly reported as the clerodane-type...

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Search results for: Maosong Qiu

Monitoring ROS Responsive Fe₃O₄‐based Nanoparticle Mediated Ferroptosis and Immunotherapy via ¹²⁹Xe MRI

Monitoring ROS Responsive Fe₃O₄‐based Nanoparticle Mediated Ferroptosis and Immunotherapy via ¹²⁹Xe MRI

Augmenting Immunotherapy via Bioinspired MOF‐Based ROS Homeostasis Disruptor with Nanozyme‐Cascade Reaction

Innenrücktitelbild: In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent ¹⁹F NMR (Angew. Chem. 50/2022)

Inside Back Cover: In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent ¹⁹F NMR (Angew. Chem. Int. Ed. 50/2022)

In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent ¹⁹F NMR

In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent ¹⁹F NMR

Simultaneous Qualitative and Quantitative Analyses of Triterpenoids in Ilex pubescens by Ultra‐High‐Performance Liquid Chromatography Coupled with Quadrupole Time‐of‐Flight Mass Spectrometry

Diterpenoids from Croton crassifolius include a novel skeleton possibly generated via an intramolecular [2+2]-photocycloaddition reaction

Two new hydroxylated ent-kauranoic acids from Pteris semipinnata

New clerodane diterpenoids from Croton crassifolius

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