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Background
Amplification of HER2, a receptor tyrosine kinase and a breast cancer‐linked oncogene, is associated with aggressive disease. HER2 protein is localised mostly at the cell membrane, but a fraction translocates to mitochondria. Whether and how mitochondrial HER2 contributes to tumorigenicity is currently unknown.
Methods
We enriched the mitochondrial (mt‐)HER2 fraction in breast cancer...