Search results for: David Hallett

Items from 1 to 10 out of 10 results

article

Outcomes of coronavirus disease 2019 (COVID‐19) and risk factors associated with severe COVID‐19 in patients with mature B‐cell non‐Hodgkin lymphomas: A US electronic health record cohort study

Xiaomeng Yue, David Hallett, Yangyang Liu, Elisa Basa, more

European Journal of Haematology > 110 > 2 > 177 - 187

Objectives The objectives of this study were to assess the risk of severe coronavirus disease 2019 (COVID‐19) outcomes in patients with mature B‐cell non‐Hodgkin lymphoma (mature B‐cell NHL) compared with other cancers and to identify risk factors associated with severe COVID‐19. Methods This study used Optum's electronic health record database. Risk factors were evaluated using multivariable logistic...

article

Predictors of cinacalcet discontinuation and reinitiation in hemodialysis patients: results from 7 European countries

Douglas S. Fuller, David Hallett, Paul J. Dluzniewski, Bruno Fouqueray, more

BMC Nephrology > 2019 > 20 > 1 > 1-13

Background The putative benefits of cinacalcet therapy for management of secondary hyperparathyroidism (SHPT) are thought to be most manifested when patients are taking it consistently and as prescribed. Real-world descriptions of cinacalcet prescription discontinuation and reinitiation in European hemodialysis patients are lacking. To address this knowledge gap, we used Dialysis Outcomes and Practice...

article

Evaluation of standard and modified severity of illness scores in the obstetric patient

Stephen E. Lapinsky, David Hallett, Nancy Collop, John Drover, more

Journal of Critical Care > 2011 > 26 > 5 > 535.e1-535.e7

To test discrimination and calibration of APACHE-II and SAPS-II risk prediction scores in a cohort of obstetric patients, and to evaluate the effect of modifying these scores for the physiological changes in pregnancy.A retrospective review of obstetric patients, 12 weeks gestation to 48 hours postpartum, admitted to the ICU for more than 24 hours. APACHE-II and SAPS-II, and versions modified for...

article

Fragments: past, present and future

Mark Whittaker, Richard J. Law, Osamu Ichihara, Thomas Hesterkamp, more

Drug Discovery Today: Technologies > 2010 > 7 > 3 > e163-e171

Fragment-based drug discovery has come a long way in a short period of time and is now being used throughout the biopharmaceutical industry. Here we review the origin of the approach, discuss how it is being applied and the prospects for future development. We illustrate this with examples from our own projects where we have found that information from fragments can inform the optimisation of hits...

article

Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays

Robert Godemann, James Madden, Joachim Krämer, Myron Smith, more

Biochemistry > 2009 > 48 > 45 > 10743 - 10751

article

The histamine H3 receptor as a therapeutic drug target for CNS disorders

Mark J. Gemkow, Adam J. Davenport, Silke Harich, Bart A. Ellenbroek, more

Drug Discovery Today > 2009 > 14 > 9-10 > 509-515

The histamine H3 receptor plays a regulatory role in the pre-synaptic release of histamine and other neurotransmitters, making it an attractive target for CNS indications including cognitive disorders, narcolepsy, ADHD and pain. As more and more H3 antagonists/H3 inverse agonists progress through the clinic, knowledge is gained to define the profile of the ‘ideal’ compound in terms of specificity,...

article

A multicenter survey of Ontario intensive care unit nurses regarding the use of sedatives and analgesics for adults receiving mechanical ventilation

Sangeeta Mehta, Maureen O. Meade, Patricia Hynes, Woganee A. Filate, more

Journal of Critical Care > 2007 > 22 > 3 > 191-196

Nursing-directed sedation protocols have been shown to reduce the duration of mechanical ventilation and shorten the length of intensive care unit (ICU) stay among critically ill adult patients.We designed a self-administered questionnaire to understand nurses' satisfaction with current sedation and analgesia practices as well as drug therapies in the ICU setting and the perceived relevance of sedation...

article

8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABAA receptor

Alexander C. Humphries, Emanuela Gancia, Myra T. Gilligan, Simon Goodacre, more

Bioorganic & Medicinal Chemistry Letters > 2006 > 16 > 6 > 1518-1522

8-Fluoroimidazo[1,2-a]pyridine has been established as a physicochemical mimic of imidazo[1,2-a]pyrimidine, using both in silico and traditional techniques. Furthermore, a novel synthesis of a 3,7-disubstituted-8-fluoroimidazopyridine 3 has been developed and the utility of the physicochemical mimicry has been demonstrated in an in vitro system. Here, the 8-fluoroimidazopyridine ring contained in...

article

High values of the pulmonary artery wedge pressure in patients with acute lung injury and acute respiratory distress syndrome

Niall Ferguson, Maureen Meade, David Hallett, Thomas Stewart

Intensive Care Medicine > 2002 > 28 > 8

Objective. To determine the incidence and severity of pulmonary artery wedge pressure (PAWP) elevation in patients with ALI/ARDS. In addition, to examine the effects of clinical variables on the presence of a high PAWP (18mmHg) and the effect of an elevated PAWP on mortality. Design and patients. Post hoc analysis of 120 patients with or at high risk of ARDS, enrolled in a randomized controlled trial...

article

Dimerization of o-Hydroxycyclohexadienones Related to Calicheamicinone: S _N 2 Displacement of the 12α-Hydroxyl Group

Ian Churcher, David Hallett, Philip Magnus

Tetrahedron > 1999 > 55 > 6 > 1597-1606

Deprotection of the readily available bicyclo[7.3.1]enediyne alcohol 14 resulted in dimerization to give 18. Replacement of the 12α-hydroxyl group with a p-methoxyanilino group proceeded with overall retention to give 23 which also produced a dimer on attempted deprotection.

Filter options

Publication date

Last 3 years (1)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Keywords

Data set

Elsevier (6)
Springer (2)
ACS (1)
Wiley (1)

Journal

Journal of Critical Care (2)
BMC Nephrology (1)
Biochemistry (1)
Bioorganic & Medicinal Chemistry Letters (1)
Drug Discovery Today (1)
Drug Discovery Today: Technologies (1)
European Journal of Haematology (1)
Intensive Care Medicine (1)
Tetrahedron (1)

INFONA - science communication portal

Search results for: David Hallett

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options