Search results for: Jean‐Noel Trochu

Items from 1 to 20 out of 44 results

article

Iron deficiency screening is a key issue in chronic inflammatory diseases: A call to action

Patrice Cacoub, Gabriel Choukroun, Alain Cohen‐Solal, Elisabeth Luporsi, more

Journal of Internal Medicine > 292 > 4 > 542 - 556

Iron deficiency is frequent in patients with chronic inflammatory conditions (e.g., chronic heart failure, chronic kidney disease, cancers, and bowel inflammatory diseases). Indeed, high concentrations of inflammatory cytokines increase hepcidin concentrations that lead to the sequestration of iron in cells of the reticuloendothelial system (functional iron deficiency). Iron parameters are often assessed...

article

Primary endpoint adjudication: comparison between the expert committee and the regulatory MedDRA® coding in the MITRA‐FR study

Anthony Facile, Nathan Mewton, Marina Nguon, Guy Durand de Gevigney, more

European Journal of Heart Failure > 24 > 2 > 396 - 398

article

Early nebivolol treatment is beneficial in myocardial infarction in rats partly through β3‐adrenoceptor remodelling

Leslie Audigane, Antoine Persello, Nicolas Piriou, Marine Ferron, more

Clinical and Experimental Pharmacology and Physiology > 48 > 7 > 1007 - 1015

It remains unknown whether β‐blockers are useful and safe in acute myocardial infarction (MI). Owing to its pharmacological profile and vasodilating action, nebivolol (N) is useful in MI. The aim of the present study was to assess in rat whether early nebivolol treatment could be beneficial in MI. It remains unknown whether β‐blockers are useful and safe in acute MI. On day (D) 0, male Sprague‐Dawley...

article

Percutaneous repair or medical treatment for secondary mitral regurgitation: outcomes at 2 years

Bernard Iung, Xavier Armoiry, Alec Vahanian, Florent Boutitie, more

European Journal of Heart Failure > 21 > 12 > 1619 - 1627

Aims The MITRA‐FR trial showed that among symptomatic patients with severe secondary mitral regurgitation, percutaneous repair did not reduce the risk of death or hospitalization for heart failure at 12 months compared with guideline‐directed medical treatment alone. We report the 24‐month outcome from this trial. Methods and results At 37 centres, we randomly assigned 304 symptomatic heart failure...

article

Geriatric factors associated with 1-year mortality after aortic valve replacement

Anne Sophie Boureau, Guillaume Chapelet, Marguerite Paille, Jean Noel Trochu, more

European Geriatric Medicine > 2018 > 9 > 6 > 845-851

Background Surgical aortic valve replacement has been shown to improve survival and quality of life in patients with severe aortic stenosis. However, clinical variables are known to be associated with an increased mortality rate. As geriatric conditions are highly prevalent in this older population, the aim of this study was to identify geriatric factors associated with 1-year mortality after a surgical...

article

Screening for heart transplantation and left ventricular assist system: results from the ScrEEning for advanced Heart Failure treatment (SEE‐HF) study

Lars H. Lund, Jean‐Noel Trochu, Bart Meyns, Kadir Caliskan, more

European Journal of Heart Failure > 20 > 1 > 152 - 160

Background Heart transplantation (HTx) and implantable left ventricular assist systems (LVAS) improve outcomes in advanced heart failure but may be underutilized. We hypothesized that screening can identify appropriate candidates. Methods and results The ScrEEning for advanced Heart Failure treatment (SEE‐HF) study was a multicentre prospective study screening patients with existing cardiac resynchronization...

article

Effects of pre-load variations on hemodynamic parameters with a pulsatile autoregulated artificial heart during the early post-operative period

Philippe Bizouarn, Jean-Christian Roussel, Jean-Noël Trochu, Jean-Christophe Perlès, more

The Journal of Heart and Lung Transplantation > 2018 > 37 > 1 > 161-163

article

Non-vitamin K antagonist oral anticoagulants and heart failure

Richard Isnard, Fabrice Bauer, Alain Cohen-Solal, Thibaud Damy, more

Archives of Cardiovascular Diseases > 2016 > 109 > 11 > 641-650

Thromboembolism contributes to morbidity and mortality in patients with heart failure (HF), and atrial fibrillation (AF) is one of the main factors promoting this complication. As they share many risk factors, HF and AF frequently coexist, and patients with both conditions are at a particularly high risk of thromboembolism. Non-vitamin K antagonist oral anticoagulants (NOACs) are direct antagonists...

article

Drug-induced aortic valve stenosis: An under recognized entity

Pierre-Vladimir Ennezat, Patrick Bruneval, Daniel Czitrom, Jean-Pierre Gueffet, more

International Journal of Cardiology > 2016 > 220 > C > 429-434

We have been intrigued by the observation that aortic stenosis (AS) may be associated with characteristic features of mitral drug-induced valvular heart disease (DI-VHD) in patients exposed to valvulopathic drugs, thus suggesting that beyond restrictive heart valve regurgitation, valvulopathic drugs may be involved in the pathogenesis of AS.Herein are reported echocardiographic features, and pathological...

article

Sustained quality of life improvement after intracoronary injection of autologous bone marrow cells in the setting of acute myocardial infarction: results from the BONAMI trial

Guillaume Lamirault, Elodie Bock, Véronique Sébille, Béatrice Delasalle, more

Quality of Life Research > 2017 > 26 > 1 > 121-125

Purpose Cardiac cell therapy is a promising treatment for acute myocardial infarction (AMI), leading to cardiac function improvement. However, whether it translates into quality of life (QoL) improvement is unclear. We hypothesized that administration of bone marrow cells (BMC) to patients with AMI improves QoL. Methods In the multicenter BONAMI trial (NCT00200707), patients with reperfused AMI...

article

Speckle tracking analysis allows sensitive detection of stress cardiomyopathy in severe aneurysmal subarachnoid hemorrhage patients

Raphaël Cinotti, Nicolas Piriou, Yoann Launey, Thierry Tourneau, more

Intensive Care Medicine > 2016 > 42 > 2 > 173-182

Purpose Stress cardiomyopathy is a common life-threatening complication after aneurysmal subarachnoid hemorrhage (SAH). We hypothesized that left ventricular (LV) longitudinal strain alterations assessed with speckle tracking could identify early systolic function impairment. Methods This was an observational single-center prospective pilot controlled study conducted in a neuro-intensive care unit...

article

Predictors of ventricular remodelling in patients with reperfused acute myocardial infarction and left ventricular dysfunction candidates for bone marrow cell therapy: insights from the BONAMI trial

Alain Manrique, Patricia Lemarchand, Béatrice Delasalle, Olivier Lairez, more

European Journal of Nuclear Medicine and Molecular Imaging > 2016 > 43 > 4 > 740-748

Purpose Few data are available regarding the relation of left ventricular (LV) mechanical dyssynchrony to remodelling after acute myocardial infarction (MI) and stem cell therapy. We evaluated the 1-year time course of both LV mechanical dyssynchrony and remodelling in patients enrolled in the BONAMI trial, a randomized, multicenter controlled trial assessing cell therapy in patients with reperfused...

article

0282: Rest and exercise pulmonary hypertension in hypertrophic cardiomyopathy

Julia Abellard, Jean-Noël Trochu, Caroline Cueff, Jean-Pierre Gueffet, more

Archives of Cardiovascular Diseases Supplements > 2016 > 8 > 1 > 32

Heart failure (HF) symptoms, related to pulmonary capillary hypertension, are frequent in hypertrophic cardiomyopathy (HCM). Pulmonary hypertension (PH) is the consequence of left ventricular (LV) diastolic pressure elevation and/or functional mitral regurgitation. We aimed to evaluate determinants and prognostic significance of rest and exercise in HCM.We included 235 patients referred for clinical...

article

0049: FDG-PET imaging for the management of suspected inflammatory cardiomyopathies beyond cardiac sarcoidosis: a single center initial experience

Lucile Becoulet, Jean-Noel Trochu, Amandine Pallardy, Damien Guijarro, more

Archives of Cardiovascular Diseases Supplements > 2016 > 8 > 1 > 34

FDG-positron emission tomography (PET) has high diagnostic accuracy in cardiac sarcoidosis (CS). Beyond CS, the non invasive diagnosis of inflammatory cardiomyopathies (IC) is challenged by a lower diagnostic performance of usual tools as magnetic resonance imaging (MRI).17 consecutive patients with suspected IC had a FDG-PET to detect myocardial inflammation. From all clinical data including PET,...

article

First clinical use of a bioprosthetic total artificial heart: report of two cases

Alain Carpentier, Christian Latrémouille, Bernard Cholley, David M Smadja, more

The Lancet > 2015 > 386 > 10003 > 1556-1563

The development of artificial hearts in patients with end-stage heart disease have been confronted with the major issues of thromboembolism or haemorrhage. Since valvular bioprostheses are associated with a low incidence of these complications, we decided to use bioprosthetic materials in the construction of a novel artificial heart (C-TAH). We report here the device characteristics and its first...

article

Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients

Sophie Garnier, Christian Hengstenberg, Nicolas Lamblin, Olivier Dubourg, more

International Journal of Cardiology > 2015 > 189 > C > 105-107

article

0045 : Rest and exercise pulmonary hypertension in hypertrophic cardiomyopathy

Julia Abellard, Jean Pierre Gueffet, Caroline Cueff, Pascal De Groote, more

Archives of Cardiovascular Diseases Supplements > 2015 > 7 > 2 > 172

Heart failure (HF) symptoms, related to pulmonary capillary hypertension, are frequent in hypertrophic cardiomyopathy (HCM). Pulmonary hypertension (PH) is the consequence of left ventricular (LV) diastolic pressure elevation and/or functional mitral regurgitation. We aimed to evaluate determinants and prognostic significance of rest and exercise PH in HCM.We included 235 patients referred for clinical...

article

Economic burden of functional and organic mitral valve regurgitation

Jean-Noël Trochu, Thierry Le Tourneau, Jean-François Obadia, Gilbert Caranhac, more

Archives of Cardiovascular Diseases > 2015 > 108 > 2 > 88-96

Very little is known about the costs of mitral regurgitation (MR) in Europe.To evaluate the cost of MR from a French National Payer perspective, based on annual costs of surgical and non-surgical patients.A 12-month retrospective population-based analysis of patient demographics, outcomes and acute hospital and post-discharge resource utilizations, extracted from the 2009 French Medical Information...

article

0148: Intramyocardial transplantation of mesenchymal stromal cells for chronic myocardial ischemia and decreased left ventricular function: 1-year results of the MESAMI phase I clinical trial

Damien Guijarro, Marine Lebrin, Olivier Lairez, Philippe Bourin, more

Archives of Cardiovascular Diseases Supplements > 2015 > 7 > 1 > 20

Our aim was to investigate the safety and feasibility of transendocardial injections guided by 3-dimensional NogaStar XP mapping of autologous bone marrow-derived mesenchymal stromal cells (MSC) in patients with chronic myocardial ischemia and left ventricular dysfunction.The MESAMI 1 trial is a bicentric phase 1 study, including 10 patients with chronic myocardial ischemia. The inclusion criteria...

article

0326: Prediction of right ventricular failure after cardiac transplantation: a recipient transcriptomic study

Damien Guijarro, Jean-Pierre Gueffet, Marja Steenman, Jean-Christian Roussel, more

Archives of Cardiovascular Diseases Supplements > 2015 > 7 > 1 > 24

Right ventricle failure (RVF) is a frequent and severe complication after cardiac transplantation. However, risk stratification for RVF is poorly achieved. Development of transcriptomic biomarkers for outcome prediction in cardio-vascular diseases is promising.To identify right ventricular gene expression signature associated to RVF and to define a transcriptomic biomarker that could predict post-transplantation...

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Keywords

HEART FAILURE (9)
INSUFFISANCE CARDIAQUE (3)
BENFLUOREX (2)
CHRONIC HEART FAILURE (2)
MITRAL REGURGITATION (2)
MORTALITY (2)
MYOCARDIAL INFARCTION (2)
NEBIVOLOL (2)
NITRIC OXIDE (2)
2D STRAIN (1)
ACCIDENT VASCULAIRE CÉRÉBRAL (1)
ACUTE MYOCARDIAL INFARCTION (1)
ADVERSE DRUG REACTION (1)
AMPHETAMINES (1)
AMPHÉTAMINES (1)
ANTIVITAMINE K (1)
AORTA (1)
AORTIC (1)
AORTIC STENOSIS (1)
AORTIC VALVE STENOSIS (1)
ASSISTANCE CIRCULATOIRE MONOVENTRICULAIRE GAUCHE (1)
ASSOCIATION STUDIES (1)
ATRIAL FIBRILLATION (1)
BONE MARROW MONONUCLEAR CELLS (1)
BOWEL INFLAMMATORY DISEASE (1)
CANCER (1)
CARDIAC (1)
CARDIAC CELL THERAPY (1)
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CARDIAC SURGERY (1)
CARDIOMYOPATHY (1)
CARE MANAGEMENT (1)
CELL THERAPY (1)
CHRONIC INFLAMMATORY DISEASE (1)
CHRONIC KIDNEY DISEASE (1)
CONTRACTILITY (1)
COÛT MÉDICO-ÉCONOMIQUE (1)
DILATED CARDIOMYOPATHY (1)
DRUG INDUCED-VALVULAR HEART DISEASE (1)
DYSSYNCHRONY (1)
ECHOCARDIOGRAPHY (1)
EFFETS SECONDAIRES MÉDICAMENTEUX (1)
EXERCISE ECHOCARDIOGRAPHY (1)
FENFLURAMIN DERIVATIVES (1)
FIBRILLATION ATRIALE (1)
FIBROSE VALVULAIRE (1)
FUNCTIONAL CAPACITY (1)
GENETICS (1)
GERIATRIC ASSESSMENT (1)
HEALTH ECONOMIC COSTS (1)
HEART (1)
HEART TRANSPLANTATION (1)
HUMAN HEART (1)
HYPERTENSION ARTÉRIELLE PULMONAIRE (1)
HYPERTENSION VALVULAIRE (1)
HYPERTROPHY (1)
INSUFFISANCE CARDIAQUE AVANCÉE (1)
INSUFFISANCE MITRALE (1)
IRON DEFICIENCY (1)
ISCHEMIC HEART FAILURE (1)
LEFT VENTRICULAR ASSIST DEVICE (1)
LEFT VENTRICULAR ASSIST SYSTEM (1)
MECHANICAL CIRCULATORY SUPPORT (1)
MITRAL (1)
MITRAL STENOSIS (1)
MITRAL VALVE (1)
MORBIDITY (1)
NON-VITAMIN K ANTAGONIST ORAL ANTICOAGULANTS (1)
OXYGEN CONSUMPTION (1)
PERCUTANEOUS MITRAL VALVE REPAIR (1)
PHARMACOLOGY (1)
PRISE EN CHARGE (1)
PROPENSITY SCORE (1)
PULMONARY HYPERTENSION (1)
QUALITY OF LIFE (1)
RASCH-FAMILY MODEL (1)
RAT (1)
RIGHT VENTRICLE (1)
SCREENING (1)
SECONDARY MITRAL REGURGITATION (1)
SERUM FERRITIN (1)
SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY (1)
SPECKLE TRACKING (1)
STATINS (1)
STRESS CARDIOMYOPATHY (1)
STROKE (1)
SUBARACHNOID HEMORRHAGE (1)
SURVIVAL (1)
SYSTOLIC DYSFUNCTION (1)
TAKOTSUBO (1)
THERAPEUTIC EDUCATION (1)
THERAPEUTIC PATIENT EDUCATION (1)
TRANSFERRIN SATURATION (1)
TRANSPLANTATION CARDIAQUE (1)
VALVE MITRALE (1)
VALVULAR DYSTROPHY (1)
VALVULAR FIBROSIS (1)
VENTRICULAR REMODELING (1)
VENTRICULAR REMODELLING (1)
VENTRICULE DROIT (1)
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Elsevier (35)
Wiley (5)
Springer (4)

INFONA - science communication portal

Search results for: Jean‐Noel Trochu

Iron deficiency screening is a key issue in chronic inflammatory diseases: A call to action

Primary endpoint adjudication: comparison between the expert committee and the regulatory MedDRA® coding in the MITRA‐FR study

Early nebivolol treatment is beneficial in myocardial infarction in rats partly through β3‐adrenoceptor remodelling

Percutaneous repair or medical treatment for secondary mitral regurgitation: outcomes at 2 years

Geriatric factors associated with 1-year mortality after aortic valve replacement

Screening for heart transplantation and left ventricular assist system: results from the ScrEEning for advanced Heart Failure treatment (SEE‐HF) study

Effects of pre-load variations on hemodynamic parameters with a pulsatile autoregulated artificial heart during the early post-operative period

Non-vitamin K antagonist oral anticoagulants and heart failure

Drug-induced aortic valve stenosis: An under recognized entity

Sustained quality of life improvement after intracoronary injection of autologous bone marrow cells in the setting of acute myocardial infarction: results from the BONAMI trial

Speckle tracking analysis allows sensitive detection of stress cardiomyopathy in severe aneurysmal subarachnoid hemorrhage patients

Predictors of ventricular remodelling in patients with reperfused acute myocardial infarction and left ventricular dysfunction candidates for bone marrow cell therapy: insights from the BONAMI trial

0282: Rest and exercise pulmonary hypertension in hypertrophic cardiomyopathy

0049: FDG-PET imaging for the management of suspected inflammatory cardiomyopathies beyond cardiac sarcoidosis: a single center initial experience

First clinical use of a bioprosthetic total artificial heart: report of two cases

Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients

0045 : Rest and exercise pulmonary hypertension in hypertrophic cardiomyopathy

Economic burden of functional and organic mitral valve regurgitation

0148: Intramyocardial transplantation of mesenchymal stromal cells for chronic myocardial ischemia and decreased left ventricular function: 1-year results of the MESAMI phase I clinical trial

0326: Prediction of right ventricular failure after cardiac transplantation: a recipient transcriptomic study

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