Zbigniew Banaszkiewicz

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In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease

Marta Starczak, Ewelina Zarakowska, Martyna Modrzejewska, Tomasz Dziaman, more

Journal of Translational Medicine > 2018 > 16 > 1 > 1-11

Background A characteristic feature of malignant cells, such as colorectal cancer cells, is a profound decrease in the level of 5-hydroxymethylcytosine, a product of 5-methylcytosine oxidation by TET enzymes. Recent studies showed that ascorbate may upregulate the activity of TET enzymes in cultured cells and enhance formation of their products in genomic DNA. Methods The study included four groups...

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Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions—benign adenomas and inflammatory bowel disease

Tomasz Dziaman, Daniel Gackowski, Jolanta Guz, Kinga Linowiecka, more

Clinical Epigenetics > 2018 > 10 > 1 > 1-11

Background Active demethylation of 5-methyl-2′-deoxycytidine (5-mdC) in DNA occurs by oxidation to 5-(hydroxymethyl)-2′-deoxycytidine (5-hmdC) and further oxidation to 5-formyl-2′-deoxycytidine (5-fdC) and 5-carboxy-2′-deoxycytidine (5-cadC), and is carried out by enzymes of the ten-eleven translocation family (TETs 1, 2, 3). Decreased level of epigenetic DNA modifications in cancer tissue may be...

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Mitogenomic differences between the normal and tumor cells of colorectal cancer patients

Katarzyna Skonieczna, Boris Malyarchuk, Arkadiusz Jawień, Andrzej Marszałek, more

Human Mutation > 39 > 5 > 691 - 701

So far, a reliable spectrum of mitochondrial DNA mutations in colorectal cancer cells is still unknown, and neither is their significance in carcinogenesis. Indeed, it remains debatable whether mtDNA mutations are “drivers” or “passengers” of colorectal carcinogenesis. Thus, we analyzed 200 mitogenomes from normal and cancer tissues of 100 colorectal cancer patients. Minority variant mutations were...

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The fecal occult blood test as a tool for improved outpatient qualification for colonoscopy. A single-center experience and 10-year follow-up survey

Zbigniew Banaszkiewicz, Jacek Budzyński, Krzysztof Tojek, Paweł Jarmocik, more

Advances in Medical Sciences > 2017 > 62 > 1 > 171-176

Colonoscopy is not widely and easily available in all countries, even for symptomatic patients. This is one of the causes of tumors not being diagnosed until an advanced stage. The aim of this study was to estimate the efficacy of the fecal occult blood test (FOBT) in the diagnostic work-up of outpatients referred to a colorectal unit due to indistinct abdominal symptoms.Among 10418 consecutive symptomatic...

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Scores of nutritional risk and parameters of nutritional status assessment as predictors of in-hospital mortality and readmissions in the general hospital population

Jacek Budzyński, Krzysztof Tojek, Beata Czerniak, Zbigniew Banaszkiewicz

Clinical Nutrition > 2016 > 35 > 6 > 1464-1471

We have no “gold standard” for the diagnosis of malnutrition. The aim of this study was to determine the importance of many of the parameters used in nutritional status screening and assessment among inpatients for the prediction of in-hospital mortality, readmission and length of hospitalization.On the base of the medical documentation a retrospective analysis was performed of nutritional status...

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Heteroplasmic substitutions in the entire mitochondrial genomes of human colon cells detected by ultra-deep 454 sequencing

Katarzyna Skonieczna, Boris Malyarchuk, Arkadiusz Jawień, Andrzej Marszałek, more

Forensic Science International: Genetics > 2015 > 15 > Complete > 16-20

Mitochondrial DNA (mtDNA) heteroplasmy has been widely described from clinical, evolutionary and analytical points of view. Historically, the majority of studies have been based on Sanger sequencing. However, next-generation sequencing technologies are now being used for heteroplasmy analysis. Ultra-deep sequencing approaches provide increased sensitivity for detecting minority variants. However,...

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Inflammatory Myofibroblastic Tumor Within Ileal Intussusception as the Cause of Recurrent Abdominal Pain in a 57-Year Old Patient

Magdalena Waszak, ElŻbieta Sokólska, Zbigniew Banaszkiewicz, Artur Bała, more

Polish Journal of Surgery > 2015 > 87 > 1 > 35-38

The study presented a rare case of inflammatory myofibroblastic tumor (IMT) in a 57-year old male patient who presented with recurrent abdominal pain. He was diagnosed to have a tumor of the small intestine within ileal intussusception, demonstrated by CT enterography. The patient underwent surgery to remove the tumor with a margin of healthy tissue. Histopathological and immunohistochemical examination...

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8‐Oxo‐7,8‐dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients

Tomasz Dziaman, Zbigniew Banaszkiewicz, Krzysztof Roszkowski, Daniel Gackowski, more

International Journal of Cancer > 134 > 2 > 376 - 383

The aim of this work was to answer the question whether the broad range of parameters which describe oxidative stress and oxidatively damaged DNA and repair are appropriate prognosis factors of colon cancer (CRC) patients survival? The following parameters were analyzed for 89 CRC patients: concentration of uric acid and vitamins A, E, C in plasma; levels of 8‐oxodGuo (8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine)...

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The risk of gastric cancer in carriers of CHEK2 mutations

Urszula Teodorczyk, Cezary Cybulski, Dominika Wokołorczyk, Anna Jakubowska, more

Familial Cancer > 2013 > 12 > 3 > 473-478

CHEK2 is a tumor suppressor gene whose functions are central to the induction of cell cycle arrest and apoptosis following DNA damage. Mutations in CHEK2 have been associated with cancers at many sites, including breast and prostate cancers, but the relationship between CHEK2 and gastric cancer has not been extensively studied. In Poland, there are four known founder alleles of CHEK2; three alleles...

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Usefulness of CEA Concentration Measurement and Classic Colonoscopy in Follow-Up After Radical Treatment of Colorectal Cancer

Zbigniew Banaszkiewicz, Paweł Jarmocik, Jacek Frasz, Krzysztof Tojek, more

Polish Journal of Surgery > 2011 > 83 > 6 > 310-318

There is always a certain rate of recurrence after radical treatment for cancer and to get on it an early detection of disease set back is crucial.<bold>Material and methods.</bold> Medical data of patients operated on for primarily detected colorectal cancer in years 1993-2002 was retrospectively reviewed. Usefulness of follow-up means such as physical examination, or CEA and endoscopic...

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Usefulness of CEA Concentration Measurement and Classic Colonoscopy in Follow-Up After Radical Treatment of Colorectal Cancer

Zbigniew Banaszkiewicz, Paweł Jarmocik, Jacek Frasz, Krzysztof Tojek, more

Comparative Professional Pedagogy > 2011 > 83 > 6 > 310-318

There is always a certain rate of recurrence after radical treatment for cancer and to get on it an early detection of disease set back is crucial.<bold>Material and methods.</bold> Medical data of patients operated on for primarily detected colorectal cancer in years 1993-2002 was retrospectively reviewed. Usefulness of follow-up means such as physical examination, or CEA and endoscopic...

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Aberrant repair of etheno–DNA adducts in leukocytes and colon tissue of colon cancer patients

Tomasz Obtułowicz, Alicja Winczura, Elżbieta Speina, Maja Swoboda, more

Free Radical Biology and Medicine > 2010 > 49 > 6 > 1064-1071

To assess the role of lipid peroxidation-induced DNA damage and repair in colon carcinogenesis, the excision rates and levels of 1,N ⁶ -etheno-2′-deoxyadenosine (εdA), 3,N ⁴ -etheno-2′-deoxycytidine (εdC), and 1,N ² -etheno-2′-deoxyguanosine (1,N ² -εdG) were analyzed in polymorphic blood leukocytes (PBL) and resected colon tissues of 54 colorectal carcinoma (CRC) patients...

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CHEK2 mutations and HNPCC‐related colorectal cancer

Janina Suchy, Cezary Cybulski, Dominika Wokołorczyk, Oleg Oszurek, more

International Journal of Cancer > 126 > 12 > 3005 - 3009

Recently, the 1100delC variant of cell cycle checkpoint kinase 2 (CHEK2) has been reported to confer a colorectal cancer risk in hereditary non‐polyposis‐colorectal cancer (HNPCC) and HNPCC‐related families in the Netherlands. To investigate whether CHEK2 mutations confer increased cancer risk in HNPCC and HNPCC‐related families in Poland, we genotyped 463 probands from HNPCC and HNPCC‐related families,...

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BRCA1 mutations and colorectal cancer in Poland

Janina Suchy, Cezary Cybulski, Bohdan Górski, Tomasz Huzarski, more

Familial Cancer > 2010 > 9 > 4 > 541-544

Evidence to date that germline mutations in the tumor suppressor gene BRCA1 increase the incidence of colorectal cancer is mixed, and both positive and negative results have been reported. To establish whether or not inherited variation in BRCA1 influences the risk of colorectal cancer, we genotyped 2,398 unselected patients with colorectal cancer and 4,570 controls from Poland for three BRCA1 founder...

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Severe Course of Crohn's Disease Complicated with Multiple Peristomal Fistulas

Zbigniew Banaszkiewicz, Maria Kłopocka, Arkadiusz Jawień

Comparative Professional Pedagogy > 2009 > 81 > 4 > 198-202

To date healthy male, 51, was admitted to hospital for abdominal pain and body weight loss of 10 kilograms within 6 weeks. Soon after admittance the patient's condition deteriorated and he was operated on for ileus. The Hartman's resection of sigmoid colon was the option for obstructive tumour. First signs of stoma complications were being reported from day 16 on and soon overt multiple fistula formation...

article

Severe Course of Crohn's Disease Complicated with Multiple Peristomal Fistulas

Zbigniew Banaszkiewicz, Maria Kłopocka, Arkadiusz Jawień

Polish Journal of Surgery > 2009 > 81 > 4 > 198-202

To date healthy male, 51, was admitted to hospital for abdominal pain and body weight loss of 10 kilograms within 6 weeks. Soon after admittance the patient's condition deteriorated and he was operated on for ileus. The Hartman's resection of sigmoid colon was the option for obstructive tumour. First signs of stoma complications were being reported from day 16 on and soon overt multiple fistula formation...

article

Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients.

Daniel Gackowski, Marcin Kruszewski, Zbigniew Banaszkiewicz, Arkadiusz Jawien, more

Acta Biochimica Polonica > 2002 > 49 > 1 > 269-273

Patients with colorectal carcinoma showed statistically significant lower values of transferrin saturation, total iron binding capacity and serum iron level as compared with control group, while the level of ferritin and the size of labile iron pool in carcinoma patients were higher, although this difference was not statistically significant. Our observations are in favour of the hypothesis which...

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Search results for: Zbigniew Banaszkiewicz

In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease

Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions—benign adenomas and inflammatory bowel disease

Mitogenomic differences between the normal and tumor cells of colorectal cancer patients

The fecal occult blood test as a tool for improved outpatient qualification for colonoscopy. A single-center experience and 10-year follow-up survey

Scores of nutritional risk and parameters of nutritional status assessment as predictors of in-hospital mortality and readmissions in the general hospital population

Heteroplasmic substitutions in the entire mitochondrial genomes of human colon cells detected by ultra-deep 454 sequencing

Inflammatory Myofibroblastic Tumor Within Ileal Intussusception as the Cause of Recurrent Abdominal Pain in a 57-Year Old Patient

8‐Oxo‐7,8‐dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients

The risk of gastric cancer in carriers of CHEK2 mutations

Usefulness of CEA Concentration Measurement and Classic Colonoscopy in Follow-Up After Radical Treatment of Colorectal Cancer

Usefulness of CEA Concentration Measurement and Classic Colonoscopy in Follow-Up After Radical Treatment of Colorectal Cancer

Aberrant repair of etheno–DNA adducts in leukocytes and colon tissue of colon cancer patients

CHEK2 mutations and HNPCC‐related colorectal cancer

BRCA1 mutations and colorectal cancer in Poland

Severe Course of Crohn's Disease Complicated with Multiple Peristomal Fistulas

Severe Course of Crohn's Disease Complicated with Multiple Peristomal Fistulas

Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients.

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