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Summary. Early virological response is considered to be a predictor for the outcome of anti‐hepatitis B virus (HBV) therapy. To analyze its correlation to intrahepatic HBV DNA and covalently closed circular DNA (ccc)DNA, 71 hepatitis B virus e antigen (HBeAg)‐positive chronic hepatitis B patients were recruited: 34 patients were treated with lamivudine; 13 with interferon‐α2b; and 24 with sequential...