Search results for: Eugene P. Steffey

Items from 1 to 20 out of 30 results

article

Physiologic effects of furosemide in combination with water restriction when administered at 4 and 24 hours prior to high‐intensity treadmill training

Heather K. Knych, W. David Wilson, Alina Vale, Philip H. Kass, more

Journal of Veterinary Pharmacology and Therapeutics > 43 > 6 > 565 - 576

Although controversial, due to its reported effectiveness in attenuating bleeding associated with exercise‐induced pulmonary hemorrhage (EIPH), furosemide is currently a permitted race day medication in most North American racing jurisdictions. The objective of this study was to assess the efficacy of furosemide in reducing the presence and severity of EIPH when administered 24 hr prior to strenuous...

article

Pharmacokinetics and selected pharmacodynamics of morphine and its active metabolites in horses after intravenous administration of four doses

Briana D. Hamamoto‐Hardman, Eugene P. Steffey, Daniel Weiner, Daniel S. McKemie, more

Journal of Veterinary Pharmacology and Therapeutics > 42 > 4 > 401 - 410

The objective of the current study was to describe and characterize the pharmacokinetics and selected pharmacodynamic effects of morphine and its two major metabolites in horses following several doses of morphine. A total of ten horses were administered a single intravenous dose of morphine: 0.05, 0.1, 0.2, or 0.5 mg/kg, or saline control. Blood samples were collected up to 72 hr, analyzed for morphine,...

article

Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs

Rachel C. Hector, Marlis L. Rezende, Khursheed R. Mama, Eugene P. Steffey, more

Veterinary Anaesthesia and Analgesia > 2017 > 44 > 4 > 755-765

To determine the effects of low and high dose infusions of dexmedetomidine and a peripheral α₂-adrenoceptor antagonist, MK-467, on sevoflurane minimum alveolar concentration (MAC) in dogs.Crossover experimental study.Six healthy, adult Beagle dogs weighing 12.6±0.9 kg (mean±standard deviation).Dogs were anesthetized with sevoflurane in oxygen. After a 60-minute instrumentation and equilibration period,...

article

Methodology for determining minimum alveolar concentration: a critical appraisal

Eugene P. Steffey

Veterinary Anaesthesia and Analgesia > 2017 > 44 > 1 > 2-6

article

Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse

Heather K DiMaio Knych, Vanessa Covarrubias, Eugene P Steffey

Veterinary Anaesthesia and Analgesia > 2012 > 39 > 6 > 574-583

To describe selected pharmacodynamic effects of detomidine and yohimbine when administered alone and in sequence. Randomized crossover design. Nine healthy adult horses aged 9 ± 4 years and weighing 561 ± 56 kg. Three dose regimens were employed in the current study. 1) 0.03 mg kg⁻¹ detomidine IV, 2) 0.2 mg kg⁻¹ yohimbine IV and 3) 0.03 mg kg⁻¹ detomidine IV followed 15 minutes later by 0...

article

Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse

Heather K DiMaio Knych, Vanessa Covarrubias, Eugene P Steffey

Veterinary Anaesthesia and Analgesia > 39 > 6 > 574 - 583

Objective To describe selected pharmacodynamic effects of detomidine and yohimbine when administered alone and in sequence. Study design Randomized crossover design. Animals Nine healthy adult horses aged 9 ± 4 years and weighing 561 ± 56 kg. Methods Three dose regimens were employed in the current study. 1) 0.03 mg kg⁻¹ detomidine IV, 2) 0.2 mg kg⁻¹ yohimbine IV and 3) 0.03 mg kg⁻¹ detomidine...

article

Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses

Robert J Brosnan, Eugene P Steffey, André Escobar

Veterinary Anaesthesia and Analgesia > 2012 > 39 > 4 > 335-344

To test the hypothesis that hypercapnic hyperpnea produced using endotracheal insufflation with 5–10% CO₂ in oxygen could be used to shorten anesthetic recovery time in horses, and that recovery from sevoflurane would be faster than from isoflurane. Randomized crossover study design. Eight healthy adult horses. After 2 hours’ administration of constant 1.2 times MAC isoflurane or sevoflurane,...

article

Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses

Robert J Brosnan, Eugene P Steffey, André Escobar

Veterinary Anaesthesia and Analgesia > 39 > 4 > 335 - 344

Objective To test the hypothesis that hypercapnic hyperpnea produced using endotracheal insufflation with 5–10% CO₂ in oxygen could be used to shorten anesthetic recovery time in horses, and that recovery from sevoflurane would be faster than from isoflurane. Study design Randomized crossover study design. Animals Eight healthy adult horses. Methods After 2 hours’ administration of constant 1...

article

The effects of yohimbine on the pharmacokinetic parameters of detomidine in the horse

Heather K Knych, Eugene P Steffey, Scott D Stanley

Veterinary Anaesthesia and Analgesia > 2012 > 39 > 3 > 221-229

To describe the pharmacokinetics of detomidine and yohimbine when administered in combination. Randomized crossover design. Nine healthy adult horses aged 9 ± 4 years and weighing of 561 ± 56 kg. Three dose regimens were employed in the current study. 1) 0.03 mg kg⁻¹ detomidine IV (D), 2) 0.2 mg kg⁻¹ yohimbine IV (Y) and 3) 0.03 mg kg⁻¹ detomidine IV followed 15 minutes later by 0.2 mg kg...

article

The effects of yohimbine on the pharmacokinetic parameters of detomidine in the horse

Heather K Knych, Eugene P Steffey, Scott D Stanley

Veterinary Anaesthesia and Analgesia > 39 > 3 > 221 - 229

Objective To describe the pharmacokinetics of detomidine and yohimbine when administered in combination. Study design Randomized crossover design. Animals Nine healthy adult horses aged 9 ± 4 years and weighing of 561 ± 56 kg. Methods Three dose regimens were employed in the current study. 1) 0.03 mg kg⁻¹ detomidine IV (D), 2) 0.2 mg kg⁻¹ yohimbine IV (Y) and 3) 0.03 mg kg⁻¹ detomidine IV followed...

article

Pharmacokinetics and pharmacodynamics of intravenous medetomidine in the horse

Kristin N Grimsrud, Khursheed R Mama, Eugene P Steffey, Scott D Stanley

Veterinary Anaesthesia and Analgesia > 2012 > 39 > 1 > 38-48

To describe the pharmacodynamics and pharmacokinetics following an intravenous (IV) bolus dose of medetomidine in the horse. Prospective experimental trial. Eight, mature healthy horses age 11.7 ± 4.6 (mean ± SD) years, weighing 557 ± 54 kg. Medetomidine (10 μg kg⁻¹) was administered IV. Blood was sampled at fixed time points from before drug administration to 48 hours post administration...

article

Pharmacokinetics and pharmacodynamics of intravenous medetomidine in the horse

Kristin N Grimsrud, Khursheed R Mama, Eugene P Steffey, Scott D Stanley

Veterinary Anaesthesia and Analgesia > 39 > 1 > 38 - 48

Objective To describe the pharmacodynamics and pharmacokinetics following an intravenous (IV) bolus dose of medetomidine in the horse. Study design Prospective experimental trial. Animals Eight, mature healthy horses age 11.7 ± 4.6 (mean ± SD) years, weighing 557 ± 54 kg. Methods Medetomidine (10 μg kg⁻¹) was administered IV. Blood was sampled at fixed time points from before drug administration...

article

Determination of the sevoflurane sparing effect of methadone in cats

Tatiana H. Ferreira, Eugene P Steffey, Khursheed R. Mama, Marlis L Rezende, more

Veterinary Anaesthesia and Analgesia > 2011 > 38 > 4 > 310-319

To determine the magnitude and duration of sevoflurane minimum alveolar concentration (MAC) reduction following a single intravenous (IV) dose of methadone in cats. Prospective experimental study. Eight (four females and four males) healthy mixed-breed adult (1–2 years) cats weighing 5.82 ± 0.42 kg. Anesthesia was induced and maintained with sevoflurane. Intravenous catheters facilitated...

article

Determination of the sevoflurane sparing effect of methadone in cats

Tatiana H. Ferreira, Eugene P Steffey, Khursheed R. Mama, Marlis L Rezende, more

Veterinary Anaesthesia and Analgesia > 38 > 4 > 310 - 319

Objective To determine the magnitude and duration of sevoflurane minimum alveolar concentration (MAC) reduction following a single intravenous (IV) dose of methadone in cats. Study design Prospective experimental study. Animals Eight (four females and four males) healthy mixed‐breed adult (1–2 years) cats weighing 5.82 ± 0.42 kg. Methods Anesthesia was induced and maintained with sevoflurane....

article

A dog model to study ovary, ovarian ligament and visceral pain

Pedro Boscan, Eric Monnet, Khursheed Mama, David C Twedt, more

Veterinary Anaesthesia and Analgesia > 2011 > 38 > 3 > 260-266

A dog model was developed to study visceral pain by stimulating the ovarian ligament. Prospective experimental trial. Twelve 1-year old female hound dogs weighing 25.7 ± 3.6 kg. Dogs were anesthetized with sevoflurane. The right ovary was accessed via laparoscopy. A suture was placed around the ovarian ligament and exteriorized through the abdominal wall for stimulation. The noxious stimulus...

article

A dog model to study ovary, ovarian ligament and visceral pain

Pedro Boscan, Eric Monnet, Khursheed Mama, David C Twedt, more

Veterinary Anaesthesia and Analgesia > 38 > 3 > 260 - 266

Objective A dog model was developed to study visceral pain by stimulating the ovarian ligament. Study design Prospective experimental trial. Animals Twelve 1‐year old female hound dogs weighing 25.7 ± 3.6 kg. Methods Dogs were anesthetized with sevoflurane. The right ovary was accessed via laparoscopy. A suture was placed around the ovarian ligament and exteriorized through the abdominal wall...

article

The relationship between digital perfusion pressure and hoof lamellar blood flow in isoflurane-anesthetized horses

Robert J. Brosnan, Eugene P. Steffey, Alejandro Esteller-Vico, Betsy Vaughan, more

Research in Veterinary Science > 2011 > 90 > 1 > 138-145

Digital perfusion pressure (DPP) equals mean arterial pressure (MAP) at the hoof coronet minus digital interstitial pressure (DIP) within the hoof. To test whether lamellar blood flow (LBF) changes proportionately to DPP, anesthesia was induced and maintained with isoflurane in six horses to target a MAP of 60mmHg. Arterial, venous, and hoof interstitial pressures were measured in each pelvic limb...

article

Evaluation of cardiovascular, respiratory and biochemical effects, and anesthetic induction and recovery behavior in horses anesthetized with a 5% micellar microemulsion propofol formulation

Marlis L Rezende, Pedro Boscan, Scott D Stanley, Khursheed R Mama, more

Veterinary Anaesthesia and Analgesia > 2010 > 37 > 5 > 440-450

To characterize cardiovascular, respiratory and biochemical effects and recovery behavior associated with a 3‐hour continuous infusion of a micellar microemulsion propofol formulation in horses. Prospective experimental trial. Six healthy adult horses, 9 ± 2 years old and weighing 557 ± 14 kg. All horses received xylazine (1 mg kg⁻¹, IV) 5 minutes prior to anesthetic induction. Each horse...

article

RESEARCH PAPER: Evaluation of cardiovascular, respiratory and biochemical effects, and anesthetic induction and recovery behavior in horses anesthetized with a 5% micellar microemulsion propofol formulation

Marlis L Rezende, Pedro Boscan, Scott D Stanley, Khursheed R Mama, more

Veterinary Anaesthesia and Analgesia > 37 > 5 > 440 - 450

Objective To characterize cardiovascular, respiratory and biochemical effects and recovery behavior associated with a 3‐hour continuous infusion of a micellar microemulsion propofol formulation in horses. Study design Prospective experimental trial. Animals Six healthy adult horses, 9 ± 2 years old and weighing 557 ± 14 kg. Methods All horses received xylazine (1 mg kg⁻¹, IV) 5 minutes prior to...

article

Sedative effects of propofol in horses

Robert J. Brosnan, Eugene P. Steffey

Veterinary Anaesthesia and Analgesia > 2009 > 36 > 5 > 421-425

We hypothesized that propofol can produce rapidly-reversible, dose-dependent standing sedation in horses. Prospective randomized, blinded, experimental trial. Twelve healthy horses aged 12 ± 6 years (mean ± SD), weighing 565 ± 20 kg, and with an equal distribution of mares and geldings. Propofol was administered as an intravenous bolus at one of three randomized doses (0.20, 0.35 and 0.50...

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Keywords

EQUINE (6)
ANESTHESIA (5)
HORSE (5)
EQUINE (4)
HORSE (4)
ISOFLURANE (4)
PROPOFOL (4)
DETOMIDINE (3)
CRYSTALLOIDS (2)
DETOMIDINE (2)
KETAMINE (2)
MINIMUM ALVEOLAR CONCENTRATION (2)
ONCOTIC PRESSURE (2)
PHARMACODYNAMICS (2)
PHARMACOKINETICS (2)
PHARMACOKINETICS (2)
RECOVERY (2)
RECOVERY (2)
SEDATION (2)
SEVOFLURANE (2)
SEVOFLURANE (2)
XYLAZINE (2)
YOHIMBINE (2)
YOHIMBINE (2)
ADRENERGIC Α2-RECEPTOR ANTAGONIST (1)
ALPHA-2 ADRENERGIC AGONIST (1)
ALPHA-2 AGONIST (1)
ALPHA2-ADRENERGIC AGONIST (1)
ALPHA2‐ADRENERGIC AGONIST (1)
ALPHA‐2 ADRENERGIC AGONIST (1)
ALTITUDE (1)
ANESTHESIA RECOVERY (1)
ANTAGONIST (1)
ANTAGONIST (1)
BIOMECHANICS (1)
BRONCHOALVEOLAR LAVAGE (1)
BUTORPHANOL (1)
CARBON DIOXIDE (1)
CARBON DIOXIDE (1)
CARDIAC ARRHYTHMIAS (1)
CARDIAC ARRHYTHMIAS (1)
CAT (1)
CAT (1)
CIRCULATORY (1)
CONTRACTILE PROPERTIES (1)
DEXMEDETOMIDINE (1)
DOG (1)
EQUINE ANESTHESIA (1)
EXERCISE‐INDUCED PULMONARY HEMORRHAGE (1)
FENTANYL (1)
FOAL (1)
FOOT (1)
FUROSEMIDE (1)
HYPERCAPNIA (1)
HYPERCAPNIA (1)
INTERSTITIAL PRESSURE (1)
ISOFLURANE (1)
ISOMETRIC (1)
LAMINAR (1)
LAMINITIS (1)
LAPAROTOMY (1)
LLAMA (1)
MAC (1)
MEDETOMIDINE (1)
MEDETOMIDINE (1)
METABOLISM (1)
METHADONE (1)
METHADONE (1)
MINIMUM ALVEOLAR CONCENTRATION (1)
MK-467 (1)
MODELING (1)
MORPHINE (1)
OVARY (1)
OVARY (1)
PHARMACODYNAMICS (1)
PROPOFOL (1)
RECOVERY FROM ANESTHESIA (1)
REPRODUCTIVE TRACT (1)
REPRODUCTIVE TRACT (1)
RESPIRATORY (1)
SEDATION (1)
SPAY (1)
SPAY (1)
THIOPENTAL (1)
TOTAL INTRAVENOUS ANESTHESIA (1)
TOTAL INTRAVENOUS ANESTHESIA (1)
TRANSDERMAL APPLICATION (1)
TREADMILL (1)
VISCERAL PAIN (1)
VISCERAL PAIN (1)
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Elsevier (21)
Wiley (9)

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Search results for: Eugene P. Steffey

Physiologic effects of furosemide in combination with water restriction when administered at 4 and 24 hours prior to high‐intensity treadmill training

Pharmacokinetics and selected pharmacodynamics of morphine and its active metabolites in horses after intravenous administration of four doses

Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs

Methodology for determining minimum alveolar concentration: a critical appraisal

Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse

Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse

Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses

Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses

The effects of yohimbine on the pharmacokinetic parameters of detomidine in the horse

The effects of yohimbine on the pharmacokinetic parameters of detomidine in the horse

Pharmacokinetics and pharmacodynamics of intravenous medetomidine in the horse

Pharmacokinetics and pharmacodynamics of intravenous medetomidine in the horse

Determination of the sevoflurane sparing effect of methadone in cats

Determination of the sevoflurane sparing effect of methadone in cats

A dog model to study ovary, ovarian ligament and visceral pain

A dog model to study ovary, ovarian ligament and visceral pain

The relationship between digital perfusion pressure and hoof lamellar blood flow in isoflurane-anesthetized horses

Evaluation of cardiovascular, respiratory and biochemical effects, and anesthetic induction and recovery behavior in horses anesthetized with a 5% micellar microemulsion propofol formulation

RESEARCH PAPER: Evaluation of cardiovascular, respiratory and biochemical effects, and anesthetic induction and recovery behavior in horses anesthetized with a 5% micellar microemulsion propofol formulation

Sedative effects of propofol in horses

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