Search results for: Živadin D. Bugarčić

Items from 1 to 20 out of 37 results

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Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives

Tatjana Lazarević, Ana Rilak, Živadin D. Bugarčić

European Journal of Medicinal Chemistry > 2017 > 142 > C > 8-31

Metallodrugs offer potential for unique mechanism of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging. Current research...

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Cisplatin and cisplatin analogues perfusion through isolated rat heart: the effects of acute application on oxidative stress biomarkers

Isidora M. Stojic, Vladimir I. Zivkovic, Ivan M. Srejovic, Tamara R. Nikolic, more

Molecular and Cellular Biochemistry > 2018 > 439 > 1-2 > 19-33

Drug-induced oxidative stress can occur in numerous tissues and organ systems (liver, kidney, ear, nervous system, and cardiovascular system). Cancer therapy with cisplatin is associated with side effects to which oxidative stress may contribute. We have compared the influences of cisplatin (reference compound) and its’ analogues (dichloro(1,2-diaminocyclohexane)platinum(II) and chloro(2,2′:6′,2″-terpyridine)platinum(II))...

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Impact of aromaticity on anticancer activity of polypyridyl ruthenium(II) complexes: synthesis, structure, DNA/protein binding, lipophilicity and anticancer activity

Petar Čanović, Ana Rilak Simović, Snežana Radisavljević, Ioannis Bratsos, more

JBIC Journal of Biological Inorganic Chemistry > 2017 > 22 > 7 > 1007-1028

With the aim of assessing how the aromaticity of the inert chelating ligand can influence the activity of ruthenium(II) polypyridyl complexes, two new monofunctional ruthenium(II) complexes, [Ru(Cl-Ph-tpy)(phen)Cl]Cl (1) and [Ru(Cl-Ph-tpy)(o-bqdi)Cl]Cl (2) (where Cl-Ph-tpy = 4′-(4-chlorophenyl)-2,2′:6′,2″-terpyridine, phen = 1,10-phenanthroline, o-bqdi = o-benzoquinonediimine), were synthesized. All...

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Stability and reactivity of gold compounds – From fundamental aspects to applications

Mirjana D. Đurović, Živadin D. Bugarčić, Rudi van Eldik

Coordination Chemistry Reviews > 2017 > 338 > C > 186-206

This review summarizes the chemistry of gold(0/I/II/III) compounds and outlines progress made towards obtaining more stable coordination compounds in order to improve their application in industry and the medicinal treatment of several diseases. Special attention is given to the kinetic reactivity and thermodynamic stability of such compounds, and to their mechanisms of interaction with biological...

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New 4′-(4-chlorophenyl)-2,2′:6′,2″-terpyridine ruthenium(II) complexes: Synthesis, characterization, interaction with DNA/BSA and cytotoxicity studies

Milan M. Milutinović, Ana Rilak, Ioannis Bratsos, Olivera Klisurić, more

Journal of Inorganic Biochemistry > 2017 > 169 > C > 1-12

In this study, we have developed a series of new monofunctional Ru(II) complexes of the general formula mer-[Ru(Cl-Ph-tpy)(N-N)Cl]Cl in which Cl-Ph-tpy is 4′-(4-chlorophenyl)-2,2′:6′,2″-terpyridine, N-N is a bidentate chelating ligand (1,2-diaminoethane (en, 1), 1,2-diaminocyclohexane (dach, 2) or 2,2′-bipyridine (bpy, 3)). All complexes were fully characterized by elemental analysis and spectroscopic...

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Antiproliferative properties and biomolecular interactions of three Pd(II) and Pt(II) complexes

Lara Massai, Alessandro Pratesi, Jovana Bogojeski, Marco Banchini, more

Journal of Inorganic Biochemistry > 2016 > 165 > C > 1-6

Three Pd(II) and Pt(II) complexes with chelating mono(imidazolin-2-imine) and bis(imidazolin-2-imine) ligands i.e. [Pd(DMEAIm^iPr)Cl₂] (1) (DMEAIm^iPr, 2-(1,3-diisopropyl-4,5-dimethylimidazolin-2-imine)ethan-1-dimethylamine), [Pd(DACH(Im^iPr)₂)Cl₂] (2) (DACH(Im^iPr)₂, N,N′-(cyclohexane-1,2-diyl)bis(1,3-diisopropyl-4,5-dimethylimidazolin-2-imine)) and [Pt(DMEAIm^iPr)Cl₂] (3), are evaluated here as potential...

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New gold carbene complexes as candidate anticancer agents

Alessandro Pratesi, Damiano Cirri, Mirjana D. Đurović, Serena Pillozzi, more

BioMetals > 2016 > 29 > 5 > 905-911

Three structurally related gold(I) carbene complexes with bulky hydrophobic ligands i.e. 1–3 were investigated in solution for further consideration as candidate anticancer agents. Cytotoxic assays were subsequently conducted on bone marrow-derived preosteoclast cell line of human origin (FLG 29.1) and human colon cancer cells (HCT-116). A far greater cytotoxic activity was measured for compound 1...

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Kinetics and mechanism of the substitution reactions of some bifunctional palladium(II) complexes with different nitrogen-donor heterocycles

Milica Kosović, Željko Jaćimović, Živadin D. Bugarčić, Biljana V. Petrović

Transition Metal Chemistry > 2016 > 41 > 2 > 161-168

Substitution reactions of three Pd(II) complexes, [Pd(cbdca)Cl₂]²⁻ (cbdca = cyclobutane-1,1-dicarboxylato), [Pd(ox)Cl₂]²⁻ (ox = oxalato) and [Pd(mal)Cl₂]²⁻ (mal = malonato), with different five- and six-membered N-heterocycles, such as pyrazole, 3-amino-4-iodo-pyrazole (pzI), 5-amino-4-bromo-3-methyl-pyrazole (pzBr), 1,2,4-triazole, pyrazine, imidazole, pyridazine and pyrimidine, were investigated...

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Kinetics and mechanism of substitution reactions of the new bimetallic [{PdCl(bipy)}{μ-(NH2(CH2)6H2N)}{PtCl(bipy)}]Cl(ClO4) complex with important bio-molecules

Snežana Jovanović, Biljana Petrović, Marijana Petković, Živadin D. Bugarčić

Polyhedron > 2015 > 101 > Complete > 206-214

The new dinuclear bimetallic complex, [{PdCl(bipy)}{μ-(NH₂(CH₂)₆H₂N)}{PtCl(bipy)}]Cl(ClO₄) (bipy is 2,2′-bipyridine), has been prepared and characterized by elemental microanalysis, IR, ¹H NMR spectroscopy and MALDI-TOF mass spectrometry. Substitution reactions of the studied complex with selected biologically important ligands such as: thiourea (Tu), l-methionine (l-Met), l-cysteine (l-Cys), l-histidine...

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Kinetics, mechanism and equilibrium studies on the substitution reactions of Pd(II) in reference to Pt(II) complexes with bio-molecules

Živadin D. Bugarčić, Jovana Bogojeski, Rudi van Eldik

Coordination Chemistry Reviews > 2015 > 292 > Complete > 91-106

An overview of the research in the field of kinetics and mechanisms of substitution reactions of Pd(II) complexes with sulfur and nitrogen donor bio-molecules is presented here. Pd(II) complexes are often used in research projects as a model for Pt(II) complexes since their behavior in solution is very similar. The most important difference is that Pd(II) complexes react 10 ³ –10 ⁵ ...

article

Mechanism of the reactions of ruthenium(II) polypyridyl complexes with thiourea, sulfur-containing amino acids and nitrogen-containing heterocycles

Ana Rilak, Ralph Puchta, Živadin D. Bugarčić

Polyhedron > 2015 > 91 > Complete > 73-83

The substitution reactions of ruthenium(II) polypyridyl complexes [Ru(Cl-tpy)(en)Cl][Cl] (1) and [Ru(Cl-tpy)(dach)Cl][Cl] (2) (Cl-tpy=4′-chloro-2,2′:6′,2″-terpyridine, en=1,2-diaminoethane, dach=1,2-diaminocyclohexane), with sulfur- (thiourea, l-cysteine and l-methionine) and nitrogen-donor (pyrazole, 1,2,4-triazole and pyridine) biomolecules were studied in aqueous solutions (25mM Hepes buffer, 30mM...

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Platinum Complexes-Induced Cardiotoxicity of Isolated, Perfused Rat Heart: Comparison of Pt(II) and Pt(IV) Analogues Versus Cisplatin

Miroslav M. Misic, Vladimir L. Jakovljevic, Zivadin D. Bugarcic, Vladimir I. Zivkovic, more

Cardiovascular Toxicology > 2015 > 15 > 3 > 261-268

We have compared the cardiotoxicity of five platinum complexes in a model of isolated rat heart using the Langendorff technique. These effects were assessed via coronary flow (CF) and cardiac functional parameters. cis-Diamminedichloroplatinum(II) (cisplatin, CDDP), dichloro-(1,2-diaminocyclohexane)platinum(II) (Pt^(II)DACHCl₂), dichloro-(ethylenediamine)platinum(II) (Pt^(II)ENCl₂), tetrachloro-(1,2-diaminocyclohexane)platinum(IV)...

article

Substitution reactions of dinuclear platinum(II) complexes with some nitrogen nucleophiles

Enisa Selimović, Tanja Soldatović, Jovana Bogojeski, Živadin D. Bugarčić

Transition Metal Chemistry > 2015 > 40 > 2 > 137-144

The substitution reactions of dinuclear Pt(II) complexes [{ trans -Pt(NH ₃ ) ₂ Cl} ₂ ( μ -pyrazine)] ²⁺ ( Pt1 ), [{ trans -Pt(NH ₃ ) ₂ Cl} ₂ ( μ -4,4′-bipyridyl)] ²⁺ ( Pt2 ), and [{ trans -Pt(NH ₃ ) ...

article

NMR kinetic studies of the interactions between [Ru(terpy)(bipy)(H2O)]2+ and some sulfur-donor ligands

Aleksandar Mijatović, Biljana Šmit, Ana Rilak, Biljana Petrović, more

Inorganica Chimica Acta > 2013 > 394 > Complete > 552-557

Substitution reactions of monofunctional [Ru(terpy)(bipy)(H ₂ O)] ²⁺ complex, where terpy=2,2′:6′,2″-terpyridine and bipy=2,2′-bipyridine, with biologically relevant sulfur-donor nucleophiles, such as thiourea, l-methionine, l-cysteine and glutathione, are studied in aqueous solutions by ¹ H and ¹³ C NMR spectroscopy techniques. All reactions are studied at pH 7.4,...

article

Complex formation reactions of two sterically hindered platinum(II) complexes with some N-bonding ligands

Enisa Selimović, Tatjana Vulović, Biljana Petrović, Živadin D. Bugarčić, more

Transition Metal Chemistry > 2013 > 38 > 6 > 635-640

The kinetics of the complex formation reactions of two [(TL^tBu)PtCl]⁺ and [Pt(tpdm)Cl]⁺ complexes (TL^tBu = 2,6-bis[(1,3-di-tert-butylimidazolin-2-imino)methyl]pyridine and tpdm = terpyridinedimethane) with N-donor ligands, l-histidine (L-His), inosine (Ino), inosine-5′-monophosphate (5′-IMP) and guanosine-5′-monophosphate (5′-GMP), were studied. All reactions were studied under pseudo-first-order...

article

Kinetics, mechanism, and equilibrium studies of the reactions between a ruthenium(II) complex and some nitrogen- and sulfur-donor nucleophiles

Aleksandar M. Mijatović, Ratomir M. Jelić, Jovana Bogojeski, Živadin D. Bugarčić, more

Monatshefte für Chemie - Chemical Monthly > 2013 > 144 > 10 > 1489-1498

Kinetics and mechanism of the substitution reactions between [Ru(trpy)(bpy)Cl]⁺ with nucleophiles guanosine-5′-monophosphate, l-histidine, thiourea, and dimethylsulfoxide were studied spectrophotometrically in 0.1 M NaClO₄ at 310 K. The observed order of reactivity for selected ligands is: thiourea > guanosine-5′-monophosphate > l-histidine > DMSO. This order is associated with the electronic,...

article

Ligand substitution reactions of some sterically hindered Pt(II) complexes. The crystal structures of [TLtBuH2](ClO4)2·0.5H2O

Mirjana Đurović, Jovana Bogojeski, Biljana Petrović, Dejan Petrović, more

Polyhedron > 2012 > 41 > 1 > 70-76

Substitution reactions of the complexes [(TL ^t ^Bu )PtCl] ⁺ and [Pt(tpdm)Cl] ⁺ , where TL ^t ^Bu =2,6-bis[(1,3-di-tert-butylimidazolin-2-imino)methyl]pyridine and tpdm=terpyridinedimethane, with nucleophiles: thiourea, I ⁻ , Br ⁻ , NO ₂ ⁻ , pyridine and dimethyl-sulfoxide (DMSO) were studied in 0.1M NaClO ₄ aqueous solution in...

article

Substitution reactions of some novel sterically hindered monofunctional Pd(II) complexes

Aleksandar Mijatović, Jovana Bogojeski, Biljana Petrović, Živadin D. Bugarčić

Inorganica Chimica Acta > 2012 > 383 > Complete > 300-304

Substitution reactions of the monofunctional complexes [(TL ^t ^Bu )PdCl] ⁺ and [Pd(tpdm)Cl] ⁺ , where TL ^t ^Bu =2,6-bis[(1,3-di-tert-butylimidazolin-2-imino)methyl]pyridine and tpdm=terpyridinedimethane, with nucleophiles such as: thiourea, I ⁻ , Br ⁻ , NO ₂ ⁻ , pyridine and dimethyl-sulfoxide (DMSO) were studied in 0.1M NaClO ₄...

article

Cytotoxic properties of platinum(IV) and dinuclear platinum(II) complexes and their ligand substitution reactions with guanosine-5′-monophosphate

Miloš Arsenijević, Marija Milovanović, Vladislav Volarević, Dragan Čanović, more

Transition Metal Chemistry > 2012 > 37 > 5 > 481-488

The substitution reaction of the Pt(IV) complex [PtCl₄(bipy)] with guanosine-5′-monophosphate (5′-GMP) was studied by UV–Vis spectrophotometry. This reaction was investigated under pseudo-first-order conditions at 37 °C in 25 mM Hepes buffer (pH = 7.2) in the presence of 10 mM NaCl to prevent the hydrolysis of the complex. The substitution of chlorides in [{trans-Pt(NH₃)₂Cl}₂(μ-1,2-bis(4-pyridyl)ethane)](ClO...

article

Equilibrium studies between some transition metal ions and Me₆[14]dieneN₄ ligand

Ratomir Jelić, Enisa Selimović, Radivoje Nikolić, Živadin D. Bugarčić, more

Monatshefte für Chemie - Chemical Monthly > 2012 > 143 > 10 > 1357-1363

The complex formation equilibria between Me₆[14]dieneN₄ (5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene) and metal ions such as Cu²⁺, Ni²⁺, and Zn²⁺ in aqueous 0.1 M NaCl at 298 K were studied by glass electrode potentiometric titrations. The formation constants of the complexes were determined by titration of mixtures of metal ion (2.0 mM) and ligand in concentration ratios...

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Search results for: Živadin D. Bugarčić

Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives

Cisplatin and cisplatin analogues perfusion through isolated rat heart: the effects of acute application on oxidative stress biomarkers

Impact of aromaticity on anticancer activity of polypyridyl ruthenium(II) complexes: synthesis, structure, DNA/protein binding, lipophilicity and anticancer activity

Stability and reactivity of gold compounds – From fundamental aspects to applications

New 4′-(4-chlorophenyl)-2,2′:6′,2″-terpyridine ruthenium(II) complexes: Synthesis, characterization, interaction with DNA/BSA and cytotoxicity studies

Antiproliferative properties and biomolecular interactions of three Pd(II) and Pt(II) complexes

New gold carbene complexes as candidate anticancer agents

Kinetics and mechanism of the substitution reactions of some bifunctional palladium(II) complexes with different nitrogen-donor heterocycles

Kinetics and mechanism of substitution reactions of the new bimetallic [{PdCl(bipy)}{μ-(NH2(CH2)6H2N)}{PtCl(bipy)}]Cl(ClO4) complex with important bio-molecules

Kinetics, mechanism and equilibrium studies on the substitution reactions of Pd(II) in reference to Pt(II) complexes with bio-molecules

Mechanism of the reactions of ruthenium(II) polypyridyl complexes with thiourea, sulfur-containing amino acids and nitrogen-containing heterocycles

Platinum Complexes-Induced Cardiotoxicity of Isolated, Perfused Rat Heart: Comparison of Pt(II) and Pt(IV) Analogues Versus Cisplatin

Substitution reactions of dinuclear platinum(II) complexes with some nitrogen nucleophiles

NMR kinetic studies of the interactions between [Ru(terpy)(bipy)(H2O)]2+ and some sulfur-donor ligands

Complex formation reactions of two sterically hindered platinum(II) complexes with some N-bonding ligands

Kinetics, mechanism, and equilibrium studies of the reactions between a ruthenium(II) complex and some nitrogen- and sulfur-donor nucleophiles

Ligand substitution reactions of some sterically hindered Pt(II) complexes. The crystal structures of [TLtBuH2](ClO4)2·0.5H2O

Substitution reactions of some novel sterically hindered monofunctional Pd(II) complexes

Cytotoxic properties of platinum(IV) and dinuclear platinum(II) complexes and their ligand substitution reactions with guanosine-5′-monophosphate

Equilibrium studies between some transition metal ions and Me₆[14]dieneN₄ ligand

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