Search results for: Yi Yan Yang

Items from 1 to 20 out of 120 results

article

Encapsulation of Nano‐Bortezomib in Apoptotic Stem Cell‐Derived Vesicles for the Treatment of Multiple Myeloma (Small 40/2023)

Zeyuan Cao, Peiyi Li, Yuzhen Li, Manjin Zhang, more

Small > 19 > 40 > n/a - n/a

Mesenchymal Stem Cells In article number 2301748, Peiyan Yuan, Songtao Shi, Xiaoxing Kou, and co‐workers establish a naturally occurring apoptotic encapsulation system in apoptotic mesenchymal stem cells to efficiently generate stable nanodrug‐apoVs capable of improving multiple myeloma treatment in mice.

article

Encapsulation of Nano‐Bortezomib in Apoptotic Stem Cell‐Derived Vesicles for the Treatment of Multiple Myeloma

Zeyuan Cao, Peiyi Li, Yuzhen Li, Manjin Zhang, more

Small > 19 > 40 > n/a - n/a

Extracellular vesicles (EVs) are lipid bilayer nanovesicles released from living or apoptotic cells that can transport DNA, RNA, protein, and lipid cargo. EVs play critical roles in cell–cell communication and tissue homeostasis, and have numerous therapeutic uses including serving as carriers for nanodrug delivery. There are multiple ways to load EVs with nanodrugs, such as electroporation, extrusion,...

article

Bacterial Outer Membrane‐Coated Mesoporous Silica Nanoparticles for Targeted Delivery of Antibiotic Rifampicin against Gram‐Negative Bacterial Infection In Vivo

Shuang Wu, Yi Huang, Jiachang Yan, Yuzhen Li, more

Advanced Functional Materials > 31 > 35 > n/a - n/a

The efficacy of conventional antibiotics therapeutics has declined rapidly due to the emerged antibiotic resistance. There is an urgent need to develop novel approaches to address the problem of antibiotic shortage, particularly for Gram‐negative bacteria. Herein, a biomimetic nanodelivery system is proposed to enhance the bacterial targeting and uptake of rifampicin (Rif), a traditional antibiotic...

article

Subcutaneous vaccination using injectable biodegradable hydrogels for long-term immune response

Ashlynn L.Z. Lee, Chuan Yang, Shujun Gao, James L. Hedrick, more

Nanomedicine: Nanotechnology, Biology and Medicine > 2019 > 21 > C

Prolonged vaccine release enables gradual immunostimulation, providing long-term immunity. Herein, Vitamin E-PEG-Vitamin E triblock ‘ABA’ hydrogel, which is formed through physical cross-linking of flower-shaped micelles and can reside in vivo for >17 weeks, was employed for delivery of cancer preventive vaccines to provide sustained anticancer immunity. Mice vaccinated with hydrogel formulations...

article

Sensitization of Cancer Cells via Non‐Viral Delivery of Apoptosis Inducing Proteins Using a Cationic Bolaamphiphile

Karthikeyan Narayanan, Majad Khan, Began Gopalan, Jane Antony, more

Biotechnology Journal > 14 > 3 > n/a - n/a

Cationic bolaamphiphile polymers had been previously studied as efficient delivery system for the delivery of proteins with relatively low toxicity. Here, the authors investigate the use of a protein delivery system based on a cationic bolaamphiphile to sensitize cancer cells toward apoptosis‐inducing drugs as a novel approach for cancer therapy. The authors demonstrates the efficacy of the system...

article

Enthalpy-driven micellization of oligocarbonate-fluorene end-functionalized Poly(ethylene glycol)

Guangmin Wei, Shrinivas Venkataraman, Yi Yan Yang, James L. Hedrick, more

Polymer > 2018 > 134 > C > 94-103

A fluorescent pyrene probe method was applied to measure the critical micelle concentration (CMC) of oligocarbonate-fluorene end-functionalized poly(ethylene glycol) (F_mE₄₄₅F_m) triblock copolymers in water. The CMC decreases with lower temperature and higher values of the hydrophobic block length, m. When analyzed by a closed-assembly micelle model, the estimated energetic parameters find a negative...

article

Supramolecular nanofibers self-assembled from cationic small molecules derived from repurposed poly(ethylene teraphthalate) for antibiotic delivery

Shaoqiong Liu, Kazuki Fukushima, Shrinivas Venkataraman, James L. Hedrick, more

Nanomedicine: Nanotechnology, Biology and Medicine > 2018 > 14 > 1 > 165-172

Low molecular weight cationic compounds were synthesized from re-purposed poly(ethylene teraphthalate) (PET) and used to self-assemble into high aspect ratio supramolecular nanofibers for encapsulation and delivery of anionic antibiotics. The antibiotic piperacillin/tazobactam (PT) was successfully loaded into the nanofibers through ionic interaction between anionic PT and the cationic nanofibers...

article

Disruption of drug-resistant biofilms using de novo designed short α-helical antimicrobial peptides with idealized facial amphiphilicity

Jasmeet Singh Khara, Sybil Obuobi, Ying Wang, Melissa Shea Hamilton, more

Acta Biomaterialia > 2017 > 57 > C > 103-114

The escalating threat of antimicrobial resistance has increased pressure to develop novel therapeutic strategies to tackle drug-resistant infections. Antimicrobial peptides have emerged as a promising class of therapeutics for various systemic and topical clinical applications. In this study, the de novo design of α-helical peptides with idealized facial amphiphilicities, based on an understanding...

article

Highly potent antimicrobial polyionenes with rapid killing kinetics, skin biocompatibility and in vivo bactericidal activity

Shaoqiong Liu, Robert J. Ono, Hong Wu, Jye Yng Teo, more

Biomaterials > 2017 > 127 > C > 36-48

Effective antimicrobial agents are important arsenals in our perennial fight against communicable diseases, hospital-acquired and surgical site multidrug-resistant infections. In this study, we devise a strategy for the development of highly efficacious and skin compatible yet inexpensive water-soluble macromolecular antimicrobial polyionenes by employing a catalyst-free, polyaddition polymerization...

article

Biodegradable cationic poly(carbonates): Effect of varying side chain hydrophobicity on key aspects of gene transfection

Zhan Yuin Ong, Chuan Yang, Wei Cheng, Zhi Xiang Voo, more

Acta Biomaterialia > 2017 > 54 > C > 201-211

The degree of hydrophobicity in cationic polymers plays an important but often underappreciated role in the safety and efficacy of gene delivery processes. In order to further elucidate structure-activity relationships of biodegradable cationic poly(carbonate) gene carriers, we synthesized a series of narrowly dispersed homo-polymers via metal-free organocatalytic living ring-opening polymerization...

article

pH and redox dual-responsive biodegradable polymeric micelles with high drug loading for effective anticancer drug delivery

Jye Yng Teo, Willy Chin, Xiyu Ke, Shujun Gao, more

Nanomedicine: Nanotechnology, Biology and Medicine > 2017 > 13 > 2 > 431-442

Diblock copolymers of poly(ethylene glycol) (PEG) and biodegradable polycarbonate functionalized with GSH-sensitive disulfide bonds and pH-responsive carboxylic acid groups were synthesized via organocatalytic ring-opening polymerization of functional cyclic carbonates with PEG having different molecular weights as macroinitiators. These narrowly-dispersed polymers had predictable molecular weights,...

article

Au-Ag core-shell nanoparticles for simultaneous bacterial imaging and synergistic antibacterial activity

Xin Ding, Peiyan Yuan, Nengyue Gao, Hai Zhu, more

Nanomedicine: Nanotechnology, Biology and Medicine > 2017 > 13 > 1 > 297-305

Au@Ag nanoparticles (NPs) were recently found to display giant two-photon photoluminescence (2PPL) enhancement, with an enhancement factor up to 815 fold upon aggregate formation. Based on this finding, two-photon imaging of bacteria by Au@Ag NPs under near-infrared (NIR) femtosecond laser pulses was demonstrated in this study, as positively charged Au@Ag NPs can form aggregates on the negatively...

article

Biodegradable functional polycarbonate micelles for controlled release of amphotericin B

Ying Wang, Xiyu Ke, Zhi Xiang Voo, Serene Si Ling Yap, more

Acta Biomaterialia > 2016 > 46 > C > 211-220

Amphotericin B (AmB), a poorly soluble and toxic antifungal drug, was encapsulated into polymeric micelles self-assembled from phenylboronic acid-functionalized polycarbonate/PEG (PEG-PBC) and urea-functionalized polycarbonate/PEG (PEG-PUC) diblock copolymers via hydrogen-bonding, boronate ester bond, and/or ionic interactions between the boronic acid group in the micellar core and amine group in...

article

Tuning the Selectivity of Biodegradable Antimicrobial Cationic Polycarbonates by Exchanging the Counter‐Anion

Mehmet Isik, Jeremy P. K. Tan, Robert J. Ono, Ana Sanchez‐Sanchez, more

Macromolecular Bioscience > 16 > 9 > 1360 - 1367

There is a growing interest in modern healthcare to develop systems able to fight antibiotic resistant bacteria. Antimicrobial cationic biodegradable polymers able to mimic antimicrobial peptides have shown to be effective against both Gram‐positive and Gram‐negative bacteria. In these systems, the hydrophilic–hydrophobic ratio and the cationic charge density play a pivotal role in defining the killing...

article

Design and synthesis of biodegradable grafted cationic polycarbonates as broad spectrum antimicrobial agents

Zhan Yuin Ong, Daniel J. Coady, Jeremy P. K. Tan, Yan Li, more

Journal of Polymer Science Part A: Polymer Chemistry > 54 > 8 > 1029 - 1035

Several biodegradable grafted cationic polycarbonates prepared via metal‐free organocatalytic ring‐opening polymerization are investigated for their antimicrobial activity, mechanism of action, and biocompatibility.

article

Co-delivery of drugs and plasmid DNA for cancer therapy

Pei Yun Teo, Wei Cheng, James L. Hedrick, Yi Yan Yang

Advanced Drug Delivery Reviews > 2016 > 98 > C > 41-63

Cancer is an extremely complex disease involving multiple signaling pathways that enable tumor cells to evade programmed cell death, thus making cancer treatment extremely challenging. The use of combination therapy involving both gene therapy and chemotherapy has resulted in enhanced anti-cancer effects and has become an increasingly important strategy in medicine. This review will cover important...

article

Star‐Like Structure of Oligocarbonate‐Fluorene End‐Functionalized Poly(ethylene glycol) ABA Triblock Copolymers Below the Gel Point

Vivek M. Prabhu, Shrinivas Venkataraman, Yi Yan Yang, James L. Hedrick

Macromolecular Symposia > 358 > 1 > 157 - 169

ABA‐type oligocarbonate‐fluorene end‐functionalized poly(ethylene glycol) s form micelles with star‐like correlations in dilute solutions where water solvates the middle (B) poly(ethylene oxide) block. Using small‐angle neutron scattering (SANS), the star‐arm aggregation number and arm radius of gyration were characterized by Benoit's star‐polymer form factor under θ‐solvent conditions and by Alessandrini...

article

Designing α-helical peptides with enhanced synergism and selectivity against Mycobacterium smegmatis: Discerning the role of hydrophobicity and helicity

Jasmeet Singh Khara, Fang Kang Lim, Ying Wang, Xi-Yu Ke, more

Acta Biomaterialia > 2015 > 28 > C > 99-108

Recently, we reported on a series of short amphipathic α-helical peptides, comprising the backbone sequence (LLKK)₂, with the ability to kill susceptible and drug-resistant Mycobacterium tuberculosis. In this study, the effect of key physicochemical parameters including hydrophobicity and helicity of α-helical peptides on anti-mycobacterial activity and synergism with rifampicin was investigated....

article

Thermoresponsive Random Poly(ether urethanes) with Tailorable LCSTs for Anticancer Drug Delivery

Haritz Sardon, Jeremy P. K. Tan, Julian M. W. Chan, Daniele Mantione, more

Macromolecular Rapid Communications > 36 > 19 > 1761 - 1767

A new class of thermoresponsive random polyurethanes is successfully synthesized and characterized. Poly(ethylene glycol) diol (M_n = 1500 Da) and 2,2‐dimethylolpropionic acid are reacted with isophorone diisocyanate in the presence of methane sulfonic acid catalyst. It is found that these polyurethanes are thermoresponsive in aqueous media and manifest a lower critical solution temperature (LCST)...

article

Structure-directing star-shaped block copolymers: Supramolecular vesicles for the delivery of anticancer drugs

Chuan Yang, Shao Qiong Liu, Shrinivas Venkataraman, Shu Jun Gao, more

Journal of Controlled Release > 2015 > 208 > Complete > 93-105

Amphiphilic polycarbonate/PEG copolymer with a star-like architecture was designed to facilitate a unique supramolecular transformation of micelles to vesicles in aqueous solution for the efficient delivery of anticancer drugs. The star-shaped amphipilic block copolymer was synthesized by initiating the ring-opening polymerization of trimethylene carbonate (TMC) from methyl cholate through a combination...

Publication date

Last 3 years (2)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Keywords

Data set

Elsevier (84)
Wiley (27)
ACS (9)

Journal

Biomaterials (45)
Journal of Controlled Release (13)
Macromolecular Rapid Communications (12)
Biomacromolecules (5)
Nano Today (5)
Acta Biomaterialia (4)
Nanomedicine: Nanotechnology, Biology and Medicine (4)
Advanced Functional Materials (3)
Advanced Materials (3)
Langmuir (3)
Advanced Drug Delivery Reviews (2)
Journal of Colloid And Interface Science (2)
Macromolecular Bioscience (2)
Materials Science & Engineering B (2)
Small (2)
Angewandte Chemie (1)
Angewandte Chemie International Edition (1)
Biotechnology Journal (1)
Chemical Physics Letters (1)
Current Opinion in Colloid & Interface Science (1)
International Journal of Pharmaceutics (1)
Journal of Chromatography B (1)
Journal of Pharmaceutical and Biomedical Analysis (1)
Journal of Polymer Science Part A: Polymer Chemistry (1)
Macromolecular Symposia (1)
Macromolecules (1)
Materials Science & Engineering C (1)
Polymer (1)
more

INFONA - science communication portal

Search results for: Yi Yan Yang

Encapsulation of Nano‐Bortezomib in Apoptotic Stem Cell‐Derived Vesicles for the Treatment of Multiple Myeloma (Small 40/2023)

Encapsulation of Nano‐Bortezomib in Apoptotic Stem Cell‐Derived Vesicles for the Treatment of Multiple Myeloma

Bacterial Outer Membrane‐Coated Mesoporous Silica Nanoparticles for Targeted Delivery of Antibiotic Rifampicin against Gram‐Negative Bacterial Infection In Vivo

Subcutaneous vaccination using injectable biodegradable hydrogels for long-term immune response

Sensitization of Cancer Cells via Non‐Viral Delivery of Apoptosis Inducing Proteins Using a Cationic Bolaamphiphile

Enthalpy-driven micellization of oligocarbonate-fluorene end-functionalized Poly(ethylene glycol)

Supramolecular nanofibers self-assembled from cationic small molecules derived from repurposed poly(ethylene teraphthalate) for antibiotic delivery

Disruption of drug-resistant biofilms using de novo designed short α-helical antimicrobial peptides with idealized facial amphiphilicity

Highly potent antimicrobial polyionenes with rapid killing kinetics, skin biocompatibility and in vivo bactericidal activity

Biodegradable cationic poly(carbonates): Effect of varying side chain hydrophobicity on key aspects of gene transfection

pH and redox dual-responsive biodegradable polymeric micelles with high drug loading for effective anticancer drug delivery

Au-Ag core-shell nanoparticles for simultaneous bacterial imaging and synergistic antibacterial activity

Biodegradable functional polycarbonate micelles for controlled release of amphotericin B

Tuning the Selectivity of Biodegradable Antimicrobial Cationic Polycarbonates by Exchanging the Counter‐Anion

Design and synthesis of biodegradable grafted cationic polycarbonates as broad spectrum antimicrobial agents

Co-delivery of drugs and plasmid DNA for cancer therapy

Star‐Like Structure of Oligocarbonate‐Fluorene End‐Functionalized Poly(ethylene glycol) ABA Triblock Copolymers Below the Gel Point

Designing α-helical peptides with enhanced synergism and selectivity against Mycobacterium smegmatis: Discerning the role of hydrophobicity and helicity

Thermoresponsive Random Poly(ether urethanes) with Tailorable LCSTs for Anticancer Drug Delivery

Structure-directing star-shaped block copolymers: Supramolecular vesicles for the delivery of anticancer drugs

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Yi Yan Yang

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options