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•CD4/CD8 ratio<1, CMV IgG+ status and T cell repertoire and response are associated.•Changes over 5years for CD3+, CD4+, CD8+, CD19+ and CD4/CD8 ratio are found.•The proportion of individuals with CD4/CD8 ratio<1 increases over 5years.•The proportion of individuals with CD4/CD8 ratio<1 was higher in men than in women.•There was no significant association between CD4/CD8 ratio<1 and 5-year...