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Assortative mating can exert a profound influence on the phenotypic composition of the population since it may result in an increase in the frequency of the genotypes associated with extreme phenotypes. Applied to the risk for a disorder such as substance abuse, this would mean a possibility for an increase in the risk and severity of the disorder in consecutive generations. This paper reviews the...
To study the effects of neuroleptic on the peripheral serotonergic function, we measured physiologic responsivity of the platelet 5-HT 2 receptor complex in schizophrenic patients (n=27) before and after haloperidol (HD) withdrawal, as well as with normal controls (n=18). In human platelets, 5-HT amplifies the ADP-induced platelet aggregation and dense granule secretion (DGS). Such an amplification...
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