Search results for: Sol Kimel

Items from 1 to 7 out of 7 results

article

Targeting small-cell lung cancer with novel fluorescent analogs of somatostatin

Genady Kostenich, Nurit Livnah, Thomas A. Bonasera, Tamar Yechezkel, more

Lung Cancer > 2005 > 50 > 3 > 319-328

Early, accurate detection of small-cell lung cancer (SCLC), before it becomes systemic, is essential for successful treatment. Fluorescence-based imaging provides safe, sensitive detection of malignancies. Targeted delivery of fluorophores increases sensitivity of endoscopic imaging. We synthesized novel somatostatin analogs, based on backbone cyclic peptides, and conjugated them with fluorescent...

article

Monitoring PDT-induced damage using spectrally resolved reflectance imaging of tissue oxygenation

Genady Kostenich, Sol Kimel, Shahar Peled, Arie Orenstein

Cancer Letters > 2005 > 219 > 2 > 169-175

Photodynamic therapy (PDT) with chlorin e ₆ (Chl) was monitored in vivo using vital microscopy and Fourier transform spectral imaging (FT-SI). Mammary C26 colon carcinoma, implanted intradermally in a mouse, was irradiated at 650nm with various radiant exposures, 3h after administration of 5mg/kg Chl. The photodynamic response (PDR) in the skin flap with tumor was expressed as microcirculation...

article

Laparoscopic Photodynamic Diagnosis of Ovarian Cancer Using 5-Aminolevulinic Acid in a Rat Model

John K. Chan, Bradley J. Monk, David Cuccia, Huyen Pham, more

Gynecologic Oncology > 2002 > 87 > 1 > 64-70

Objective. The objective of this study was to determine the efficacy and sensitivity of laparoscopic photodynamic diagnosis to detect 5-aminolevulinic acid (ALA)-induced fluorescent tumors in an animal model.Methods. Cancer cells were injected into the peritoneum of rats to induce peritoneal carcinomatosis. After 3-4 weeks, ALA was administered to establish fluorescence in tumor nodules. All intraperitoneal...

article

Photodynamic parameters in the chick chorioallantoic membrane (CAM) bioassay for topically applied photosensitizers

Marie J. Hammer-Wilson, Lori Akian, Jenny Espinoza, Sol Kimel, more

Journal of Photochemistry & Photobiology, B: Biology > 1999 > 53 > 1-3 > 44-52

The relative efficacy of Photofrin ^® -based photodynamic therapy (PDT) has been compared with that of the second-generation photosensitizers 5-aminolevulinic acid (ALA), sulfonated chloro-aluminum phthalocyanine (AlPcS _n ), benzoporphyrin derivative monoacid ring A (BPD-MA), and lutetium texaphyrin (Lutex). PDT-induced vascular damage in the chick chorioallantoic membrane (CAM) is...

article

Systemic application of photosensitizers in the chick chorioallantoic membrane (CAM) model: photodynamic response of CAM vessels and 5-aminolevulinic acid uptake kinetics by transplantable tumors

Rene Hornung, Marie J. Hammer-Wilson, Sol Kimel, Lih-Huei Liaw, more

Journal of Photochemistry & Photobiology, B: Biology > 1999 > 49 > 1 > 41-49

The aim of this study is to modify the chick chorioallantoic membrane (CAM) model into a whole-animal tumor model for photodynamic therapy (PDT). By using intraperitoneal (IP) photosensitizer injection of the chick embryo, use of the CAM for PDT has been extended to include systemic delivery as well as topical application of photosensitizers. The model has been tested for its capability to mimic an...

article

A case of basal cell carcinoma treated with photodynamic therapy - changes in histological features and bcl-2 expression

Yoram Harth, Reuven Bergman, Varda Gotfried, Sol Kimel, more

Journal of the European Academy of Dermatology and Venereology > 1996 > 7 > 2 > 163-166

Photodynamic therapy (PDT) is based on the phototoxicity of photosensitizers, mostly porphyrins. Since systemic photodynamic therapy with δ-aminolevulinic acid (δ-ALA) causes prolonged whole-skin photosensitivity, topical photodynamic therapy was developed. We describe the histological findings and the results of immunohistochemical staining for bcl-2 protein in the basal cell carcinoma of a 71-year-old...

article

In vivo damage to chorioallantoic membrane blood vessels by porphycene-induced photodynamic therapy

Varda Gottfried, Ronit Davidi, Claudia Averbuj, Sol Kimel

Journal of Photochemistry & Photobiology, B: Biology > 1995 > 30 > 2-3 > 115-121

Photodynamic therapy (PDT) was performed in the chick embryo chorioallantoic membrane (CAM) for the purpose of quantitative evaluation of several porphycenes as potential photosensitizers. Porphycenes are structural isomers of porphine possessing lower symmetry of the macrocycle and are characterized by 10-fold higher absorption at the therapeutic wavelengths for PDT (λ > 630 nm). PDT-induced...

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Keywords

PHOTODYNAMIC THERAPY (3)
5-AMINOLEVULINIC ACID (ALA) (1)
BASAL CELL CARCINOMA (1)
BCL-2 (1)
BENZOPORPHYRIN DERIVATIVE MONOACID RING A (BPD-MA) (1)
C26 COLON CARCINOMA (1)
CAM VASCULATURE AND CAM TUMOURS (1)
CHICK CHORIOALLANTOIC MEMBRANE (1)
CHLORIN E6 (1)
FLUORESCENCE IMAGING (1)
HEMOGLOBIN/OXYHEMOGLOBIN SPECTRA (1)
HYPOXIA (1)
LASER-INDUCED FLUORESCENCE DIAGNOSTICS (1)
LUTETIUM TEXAPHYRIN (LUTEX) (1)
MICE (1)
MICROCIRCULATION (1)
PHOTODYNAMIC RESPONSE (1)
PHOTOFRIN (1)
PORPHYRINS (1)
RAT OVARIAN CANCER (1)
SECOND-GENERATION PHOTOSENSITIZERS (1)
SKIN FLAP (1)
SOMATOSTATIN CONJUGATES (1)
SULFONATED CHLORO-ALUMINUM PHTHALOCYANINE (ALPCSN) (1)
TUMOR TARGETING (1)
VASCULAR DAMAGE (1)
VIDEO MONITORING OF PHOTODYNAMIC EFFECTS (1)
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Search results for: Sol Kimel

Targeting small-cell lung cancer with novel fluorescent analogs of somatostatin

Monitoring PDT-induced damage using spectrally resolved reflectance imaging of tissue oxygenation

Laparoscopic Photodynamic Diagnosis of Ovarian Cancer Using 5-Aminolevulinic Acid in a Rat Model

Photodynamic parameters in the chick chorioallantoic membrane (CAM) bioassay for topically applied photosensitizers

Systemic application of photosensitizers in the chick chorioallantoic membrane (CAM) model: photodynamic response of CAM vessels and 5-aminolevulinic acid uptake kinetics by transplantable tumors

A case of basal cell carcinoma treated with photodynamic therapy - changes in histological features and bcl-2 expression

In vivo damage to chorioallantoic membrane blood vessels by porphycene-induced photodynamic therapy

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