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Activating transcription factor 6α (ATF6α) is essential for the endoplasmic reticulum (ER) stress response. Since recent studies suggested that ER stress is involved in the pathogenesis of type 2 diabetes mellitus, we have analyzed Atf6α-null (Atf6α −/− ) mice challenged with metabolic overload or genetic manipulations. Atf6α −/− mice were fed a high-fat diet to create diet-induced...
Stress‐mediated apoptosis may play a crucial role in loss of pancreatic β‐cell mass, contributing to the development of diabetes. We have recently identified that translational control involving the translational suppressor eIF4E binding protein‐1 (4E‐BP1) which is important for β‐cell survival under endoplasmic reticulum (ER) stress. The Eif4ebp1 gene, encoding 4E‐BP1, is a direct target of a transcription...
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