The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Treatment of 6β-chloro-6-deoxycodeine 1 or 8β-bromo-8-deoxypseudocodeine 2 with Fe(CO) 5 or Fe 2 (CO) 9 yields 6-demethoxythebaine 3 and the π-diene iron complex 4; compound 1 or 2 reacts with Mo(CO) 6 to give the π-allylic molybdenum complexes 5 and 6, respectively.
Treatment of 6β-chloro-6-deoxycodeine 1 with Pd(PPh 3 ) 4 yields 6-demethoxythebaine 2 and the π-allylic palladium complex 3, which further reacts with RZnX to give the cross-coupling product of the allylic ligand and R (compounds 5 and 6, respectively). The same products are formed upon reaction of 6β-chloro-6-deoxycodeine 1 with RZnX in the presence of catalytic amounts of Pd(PPh...