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Chromosome 3 has been implicated in a large number of cancers by karyotypic and loss of heterozygosity studies. The short arm of chromosome 3 is deleted in a variety of cancers, with at least three regions showing maximum loss. In small cell lung cancer, the region 3p21.3 is lost from one homolog in virtually all cases. We have focused on two aspects of this problem: 1) to prove that the gene at...