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Objective
Patients with juvenile‐onset systemic lupus erythematosus (JSLE) have increased atherosclerosis risk. This study investigated novel atherosclerosis progression biomarkers in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, the largest investigator‐led randomized control trial of atorvastatin versus placebo for atherosclerosis progression in JSLE, using carotid...
Objective
The purpose of this study was to establish a biorepository of clinical, metabolomic, and microbiome samples from adolescents with obesity as they undergo lifestyle modification.
Methods
A total of 223 adolescents aged 10 to 18 years with BMI ≥95th percentile were enrolled, along with 71 healthy weight participants. Clinical data, fasting serum, and fecal samples were collected at repeated...
Objective
To validate the pediatric Patient‐Reported Outcomes Measurement Information System short forms (PROMIS‐SFs) in childhood‐onset systemic lupus erythematosus (SLE) in a clinical setting.
Methods
At 3 study visits, childhood‐onset SLE patients completed the PROMIS‐SFs (anger, anxiety, depressive symptoms, fatigue, physical function‐mobility, physical function‐upper extremity, pain interference,...
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