Search results for: Kohta Miyawaki

Items from 1 to 15 out of 15 results

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B cell receptor signaling related to resistance to Helicobacter pylori eradication therapy in gastric diffuse large B cell lymphoma

Takehiro Torisu, Shinichi Kawano, Kohta Miyawaki, Hidetaka Yamamoto, more

Hematological Oncology > 39 > 1 > 145 - 147

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CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines

Ayako Takaki-Kuwahara, Yojiro Arinobu, Kohta Miyawaki, Hisakata Yamada, more

Arthritis Research & Therapy > 2019 > 21 > 1 > 1-9

Background Recent studies show that innate lymphoid cells (ILCs) contribute to the development of chronic inflammation and autoimmune disease. In this study, we assessed the ILC function in the development of rheumatoid arthritis (RA). Methods In a mouse model of collagen-induced arthritis (CIA), we identified and purified the ILC subsets in peripheral blood (PB), local lymph nodes (LNs), and joints...

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Clinicopathological features of HCV-positive splenic diffuse large B cell lymphoma

Joji Shimono, Hiroaki Miyoshi, Fumiko Arakawa, Kyohei Yamada, more

Annals of Hematology > 2019 > 98 > 5 > 1197-1207

The hepatitis C virus (HCV) is a single-stranded RNA virus which is thought to be involved in the onset of B cell lymphoma. HCV-positive diffuse large B cell lymphoma (DLBCL) has been reported to clinically manifest in extranodal lesions (e.g., in the liver, spleen, and stomach). Here, we investigated HCV-positive and -negative primary splenic DLBCL (p-spDLBCL) and non-primary splenic DLBCL (ordinary...

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306 - BM-Derived Cells Recruited to the Pancreas Constitute the Tumor Microenvironment and Promote Invasion of Pancreatic Cancer

Chika Iwamoto, Kenoki Ohuchida, Takashi Okumura, Kazuhiro Koikawa, more

Gastroenterology > 2018 > 154 > 6(S1) > S-74-S-75

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Expression of PD-1 and PD-L1 on cytotoxic T lymphocytes and immune deficiency in a patient with adult T cell leukemia/lymphoma

Toyoshi Yanagihara, Yuki Ikematsu, Koji Kato, Akiko Yonekawa, more

Annals of Hematology > 2018 > 97 > 2 > 359-360

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Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non–small cell lung cancer

Noriko Hidaka, Eiji Iwama, Naoki Kubo, Taishi Harada, more

Lung Cancer > 2017 > 108 > C > 75-82

The T790M and C797S mutations of the epidermal growth factor receptor gene (EGFR) confer resistance to first- and third-generation EGFR tyrosine kinase inhibitors (TKIs), respectively, in patients with non–small cell lung cancer (NSCLC) harboring activating mutations of EGFR. C797S has been identified in cis or in trans with T790M in tumor specimens from patients who experienced treatment failure...

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Functional interleukin‐33 receptors are expressed in early progenitor stages of allergy‐related granulocytes

Hirofumi Tsuzuki, Yojiro Arinobu, Kohta Miyawaki, Ayako Takaki, more

Immunology > 150 > 1 > 64 - 73

Interleukin‐33 (IL‐33) induces T helper type 2 (Th2) cytokine production and eosinophilia independently of acquired immunity, leading to innate immunity‐mediated allergic inflammation. Allergy‐related innate myeloid cells such as eosinophils, basophils and mast cells express the IL‐33 receptor (IL‐33R), but it is still unknown how IL‐33 regulates allergic inflammation involving these cells and their...

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Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with KitWv Mutations

Ayano Yurino, Katsuto Takenaka, Takuji Yamauchi, Takuya Nunomura, more

Stem Cell Reports > 2016 > 7 > 3 > 425-438

In human-to-mouse xenograft models, reconstitution of human hematopoiesis is usually B-lymphoid dominant. Here we show that the introduction of homozygous Kit^Wv mutations into C57BL/6.Rag2^nullIl2rg^null mice with NOD-Sirpa (BRGS) strongly promoted human multi-lineage reconstitution. After xenotransplantation of human CD34⁺CD38⁻ cord blood cells, these newly generated C57BL/6.Rag2^nullIl2rg^nullNOD-Sirpa...

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Mogamulizumab Treatment Prior to Allogeneic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-versus-Host Disease

Takeshi Sugio, Koji Kato, Takatoshi Aoki, Takanori Ohta, more

Biology of Blood and Marrow Transplantation > 2016 > 22 > 9 > 1608-1614

Mogamulizumab (MOG), a humanized anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, has recently played an important role in the treatment of adult T cell leukemia/lymphoma (ATLL). Because CCR4 is expressed on normal regulatory T cells as well as on ATLL cells, MOG may accelerate graft-versus-host disease (GVHD) by eradicating regulatory T cells in patients with allogeneic hematopoietic stem...

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Sophora Flavescens Suppresses Lung Eosinophilia By Inhibiting Both Eosinophil Hematopoiesis and Migration

Hirofumi Tsuzuki, Yojiro Arinobu, Kohta Miyawaki, Ayako Takaki, more

Journal of Allergy and Clinical Immunology > 2016 > 137 > 2(S) > AB166

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A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression

Yoshikane Kikushige, Toshihiro Miyamoto, Junichiro Yuda, Siamak Jabbarzadeh-Tabrizi, more

Cell Stem Cell > 2015 > 17 > 3 > 341-352

Signaling mechanisms underlying self-renewal of leukemic stem cells (LSCs) are poorly understood, and identifying pathways specifically active in LSCs could provide opportunities for therapeutic intervention. T-cell immunoglobin mucin-3 (TIM-3) is expressed on the surface of LSCs in many types of human acute myeloid leukemia (AML), but not on hematopoietic stem cells (HSCs). Here, we show that TIM-3...