Anthony W. Ferrante

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Physiology of Energy Expenditure in the Weight‐Reduced State

Eric Ravussin, Steven R. Smith, Anthony W. Ferrante

Obesity > 29 > S1 > S31 - S38

Although many individuals achieve weight loss of 10% or more, the ability to maintain a reduced body mass over months and years is much rarer. Unfortunately, our understanding of the adverse consequences of having overweight and obesity argues that long‐term maintenance of a reduced weight provides the greatest health benefit. However, to achieve long‐term weight reduction requires overcoming neuroendocrine...

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Reduced plasma albumin predicts type 2 diabetes and is associated with greater adipose tissue macrophage content and activation

Douglas C. Chang, Xiaoyuan Xu, Anthony W. Ferrante, Jonathan Krakoff

Diabetology & Metabolic Syndrome > 2019 > 11 > 1 > 1-8

Background Plasma albumin is reduced during inflammation. Obesity, a strong risk factor for type 2 diabetes (T2D), is associated with adipose tissue inflammation. However, whether albumin is associated with adipose tissue inflammation and whether it predicts T2D are unclear. Methods Adults (predominantly American Indian) from a longitudinal study were included. Macrophage content and gene expression...

article

Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding

Yann Ravussin, Ethan Edwin, Molly Gallop, Lumei Xu, more

Cell Metabolism > 2018 > 28 > 2 > 289-299.e5

Weight is defended so that increases or decreases in body mass elicit responses that favor restoration of one's previous weight. While much is known about the signals that respond to weight loss and the central role that leptin plays, the lack of experimental systems studying the overfed state has meant little is known about pathways defending against weight gain. We developed a system to study this...

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Macrophage and adipocyte IGF1 maintain adipose tissue homeostasis during metabolic stresses

Hye Rim Chang, Hae Jin Kim, Xiaoyuan Xu, Anthony W. Ferrante

Obesity > 24 > 1 > 172 - 183

ObjectiveInsulin‐like growth factor‐1 (IGF1) regulates differentiation and growth of tissues and reduces stress and injury. IGF1 also in a tissue‐specific manner modulates the differentiation and lipid storage capacity of adipocytes in vitro, but its roles in adipose tissue development and response to stress are not known. MethodsTo study IGF1 in vivo, the cellular sources of adipose tissue Igf1...

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Keeping Off the Weight with DCs

Ethan A. Edwin, Anthony W. Ferrante

Immunity > 2015 > 43 > 4 > 624-626

Long studied as modulators of insulin sensitivity, adipose tissue immune cells have recently been implicated in regulating fat mass and weight gain. In this issue of Immunity, Reisner and colleagues (2015) report that ablation of perforin-expressing dendritic cells induces T cell expansion, worsening autoimmunity and surprisingly increasing adiposity.

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Metabolic Inflexibility Impairs Insulin Secretion and Results In MODY-like Diabetes in Triple FoxO-Deficient Mice

Ja Young Kim-Muller, Shangang Zhao, Shekhar Srivastava, Yves Mugabo, more

Cell Metabolism > 2014 > 20 > 4 > 593-602

Pancreatic β cell failure in type 2 diabetes is associated with functional abnormalities of insulin secretion and deficits of β cell mass. It’s unclear how one begets the other. We have shown that loss of β cell mass can be ascribed to impaired FoxO1 function in different models of diabetes. Here we show that ablation of the three FoxO genes (1, 3a, and 4) in mature β cells results in early-onset,...

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A Missing Link in Body Weight Homeostasis: The Catabolic Signal of the Overfed State

Yann Ravussin, Rudolph L. Leibel, Anthony W. Ferrante

Cell Metabolism > 2014 > 20 > 4 > 565-572

Mammals regulate fat mass so that increases or reductions in adipose tissue mass activate responses that favor return to one’s previous weight. A reduction in fat mass activates a system that increases food intake and reduces energy expenditure; conversely, overfeeding and rapid adipose tissue expansion reduces food intake and increases energy expenditure. With the identification of leptin nearly...

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Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

Xiaoyuan Xu, Ambar Grijalva, Alicja Skowronski, Marco van Eijk, more

Cell Metabolism > 2013 > 18 > 6 > 816-830

Obesity activates a complex systemic immune response that includes the recruitment of macrophages and other immune cells to key metabolic tissues. Current models postulate that obesity and excess lipids classically activate macrophages, polarizing them toward an M1 (inflammatory) state. Little is known about noninflammatory functions of adipose tissue macrophages (ATMs). Here, we show that the expansion...

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Chronic Helicobacter felis Infection Exacerbates Glucose Intolerance in Diet-Induced Obese Mice

Russell Ericksen, Kelly S. Betz, Anthony W. Ferrante, Timothy C. Wang

Gastroenterology > 2011 > 140 > 5 Supplement 1 > S-322

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Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism

K. Ganesh Kumar, James L. Trevaskis, Daniel D. Lam, Gregory M. Sutton, more

Cell Metabolism > 2008 > 8 > 6 > 468-481

Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated. Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis Associated (Enho), expressed in liver and brain. Liver Enho expression is regulated by nutrition: lean C57BL/6J mice fed high-fat diet (HFD) exhibited a rapid increase, while fasting reduced expression compared to controls. However,...

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Genomic Profiling of Left and Right Ventricular Hypertrophy in Congenital Heart Disease

Beth D. Kaufman, Manisha Desai, Sushma Reddy, Juan Carlos Osorio, more

Journal of Cardiac Failure > 2008 > 14 > 9 > 760-767

The right ventricle (RV) has a lower ability than the left ventricle (LV) to adapt to systemic load. The molecular basis of these differences is not known. We compared hypertrophy-signaling pathways between the RV and the LV in patients with congenital heart disease (CHD).Gene expression was measured using DNA microarrays in myocardium from children with CHD with LV or RV obstructive lesions undergoing...

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Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

Justin I. Odegaard, Roberto R. Ricardo-Gonzalez, Alex Red Eagle, Divya Vats, more

Cell Metabolism > 2008 > 7 > 6 > 496-507

Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin resistance and type 2 diabetes. While inflammatory activation of resident hepatic macrophages potentiates insulin resistance, the functions of alternatively activated Kupffer cells in metabolic disease remain unknown. Here we show that in response to the Th2 cytokine interleukin-4 (IL-4), peroxisome proliferator-activated...

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1114-198 Genomic profiles of left ventricular and right ventricular hypertrophy in congenital heart disease

Beth D Kaufman, Juan C Osorio, Manisha Desai, Jonathan Chen, more

Journal of the American College of Cardiology > 2004 > 43 > 5(S2) > A386

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Search results for: Anthony W. Ferrante

Physiology of Energy Expenditure in the Weight‐Reduced State

Reduced plasma albumin predicts type 2 diabetes and is associated with greater adipose tissue macrophage content and activation

Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding

Macrophage and adipocyte IGF1 maintain adipose tissue homeostasis during metabolic stresses

Keeping Off the Weight with DCs

Metabolic Inflexibility Impairs Insulin Secretion and Results In MODY-like Diabetes in Triple FoxO-Deficient Mice

A Missing Link in Body Weight Homeostasis: The Catabolic Signal of the Overfed State

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

Chronic Helicobacter felis Infection Exacerbates Glucose Intolerance in Diet-Induced Obese Mice

Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism

Genomic Profiling of Left and Right Ventricular Hypertrophy in Congenital Heart Disease

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

1114-198 Genomic profiles of left ventricular and right ventricular hypertrophy in congenital heart disease

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