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This review highlights the role of several immunomodulating elements contributing to the tumor microenvironment of various pediatric renal tumors including Wilms tumor. The roles of innate and adaptive immune cells in renal tumors are summarized as well as immunomodulatory cytokines and other proteins. The expression and the predictive role of checkpoint modulators like PD‐L1 and immunomodulating...
BackgroundTo investigate the immune status among pediatric patients with aplastic anemia (AA) and explore PNH‐status, T‐regulatory and NK‐cell frequency as potential markers of clinical response.
MethodsData were retrospectively analyzed from twenty‐six patients diagnosed with AA. PNH populations, T‐ and NK‐subsets were determined via flow cytometry.
ResultsAt diagnosis, 9/23 patients with severe...
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