Search results for: Lars Nyberg

Items from 1 to 20 out of 142 results

article

5‐Year Associations among Cerebral Arterial Pulsatility, Perivascular Space Dilation, and White Matter Lesions

Tomas Vikner, Nina Karalija, Anders Eklund, Jan Malm, more

Annals of Neurology > 92 > 5 > 871 - 881

Objective High cerebral arterial pulsatility index (PI), white matter lesions (WMLs), enlarged perivascular spaces (PVSs), and lacunar infarcts are common findings in the elderly population, and considered indicators of small vessel disease (SVD). Here, we investigate the potential temporal ordering among these variables, with emphasis on determining whether high PI is an early or delayed manifestation...

article

Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years

Sophia Frangou, Amirhossein Modabbernia, Steven C. R. Williams, Efstathios Papachristou, more

Human Brain Mapping > 43 > 1 > 431 - 451

Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large‐scale studies. In response, we used cross‐sectional data from 17,075 individuals aged 3–90 years from the Enhancing Neuroimaging...

article

Greater male than female variability in regional brain structure across the lifespan

Lara M Wierenga, Gaelle E Doucet, Danai Dima, Ingrid Agartz, more

Human Brain Mapping > 43 > 1 > 470 - 499

For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes,...

article

Effects of copy number variations on brain structure and risk for psychiatric illness: Large‐scale studies from the ENIGMA working groups on CNVs

Ida E. Sønderby, Christopher R. K. Ching, Sophia I. Thomopoulos, Dennis Meer, more

Human Brain Mapping > 43 > 1 > 300 - 328

The Enhancing NeuroImaging Genetics through Meta‐Analysis copy number variant (ENIGMA‐CNV) and 22q11.2 Deletion Syndrome Working Groups (22q‐ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain development and related cognitive, psychiatric and behavioral manifestations. To that end, the ENIGMA‐CNV WG has collated CNV and magnetic resonance imaging (MRI)...

article

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years

Danai Dima, Amirhossein Modabbernia, Efstathios Papachristou, Gaelle E. Doucet, more

Human Brain Mapping > 43 > 1 > 452 - 469

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta‐Analysis...

article

Mapping the landscape of human dopamine D2/3 receptors with [¹¹C]raclopride

Goran Papenberg, Lars Jonasson, Nina Karalija, Jarkko Johansson, more

Brain Structure and Function > 2019 > 224 > 8 > 2871-2882

The dopamine D2/3 system is fundamental for sensory, motor, emotional, and cognitive aspects of behavior. Small-scale human histopathological and animal studies show high density of D2/3 dopamine receptors (D2/3DR) in striatum, but also demonstrate the existence of such receptors across cortical and limbic regions. Assessment of D2/3DR BP_ND in the extrastriatal regions with [¹¹C]raclopride has long...

article

The Cone Evasion Walk test: Reliability and validity in acute stroke

Hanna Sjöholm, Staffan Hägg, Lars Nyberg, Bo Rolander, more

Physiotherapy Research International > 24 > 1 > n/a - n/a

Objective To estimate the reliability and validity of the Cone Evasion Walk test (CEW), a new test assessing the ability to evade obstacles, in people with acute stroke. Methods To estimate the reliability of the CEW, video recordings of 20 people with acute stroke performing the test were assessed by 10 physiotherapists on two occasions, resulting in a total of 400 ratings. Patients performed...

article

Working memory training mostly engages general-purpose large-scale networks for learning

Juha Salmi, Lars Nyberg, Matti Laine

Neuroscience & Biobehavioral Reviews > 2018 > 93 > C > 108-122

The present meta-analytic study examined brain activation changes following working memory (WM) training, a form of cognitive training that has attracted considerable interest. Comparisons with perceptual-motor (PM) learning revealed that WM training engages domain-general large-scale networks for learning encompassing the dorsal attention and salience networks, sensory areas, and striatum. Also the...

article

The retrosplenial cortex: A memory gateway between the cortical default mode network and the medial temporal lobe

Neda Kaboodvand, Lars Bäckman, Lars Nyberg, Alireza Salami

Human Brain Mapping > 39 > 5 > 2020 - 2034

The default mode network (DMN) involves interacting cortical areas, including the posterior cingulate cortex (PCC) and the retrosplenial cortex (RSC), and subcortical areas, including the medial temporal lobe (MTL). The degree of functional connectivity (FC) within the DMN, particularly between MTL and medial‐parietal subsystems, relates to episodic memory (EM) processes. However, past resting‐state...

article

Cognitive medicine – a new approach in health care science

Anders Wallin, Petronella Kettunen, Per M. Johansson, Ingibjörg H. Jonsdottir, more

BMC Psychiatry > 2018 > 18 > 1 > 1-5

Background The challenges of today’s society call for more knowledge about how to maintain all aspects of cognitive health, such as speed/attention, memory/learning, visuospatial ability, language, executive capacity and social cognition during the life course. Main text Medical advances have improved treatments of numerous diseases, but the cognitive implications have not been sufficiently addressed...

article

Cognitive control in the prefrontal cortex: A central or distributed executive?

Lars Nyberg

Scandinavian Journal of Psychology > 59 > 1 > 62 - 65

Cognitive control is the foundation for attaining goals by flexible adaptation of action to changing environmental demands. It has been hypothesized to be critically dependent upon the prefrontal cortex (PFC). In this mini‐review, evidence for domain‐general versus domain‐specific cognitive control is examined, with a particular focus on attention and memory. The reviewed studies examined different...

article

Both psychological factors and physical performance are associated with fall-related concerns

Mascha Pauelsen, Lars Nyberg, Ulrik Röijezon, Irene Vikman

Aging Clinical and Experimental Research > 2018 > 30 > 9 > 1079-1085

Background Fall-related concern strongly correlates to activity avoidance in older people. In this complex phenomenon, different terminology and instruments are often used interchangeably. Three main concepts make up fall-related concerns: fear of falling, consequence concern, and falls self-efficacy. It is suggested that fall-related concerns are mediated by psychological and physical factors. ...

article

Decreased prefrontal functional brain response during memory testing in women with Cushing’s syndrome in remission

Oskar Ragnarsson, Andreas Stomby, Per Dahlqvist, Johan A. Evang, more

Psychoneuroendocrinology > 2017 > 82 > C > 117-125

Neurocognitive dysfunction is an important feature of Cushing’s syndrome (CS). Our hypothesis was that patients with CS in remission have decreased functional brain responses in the prefrontal cortex and hippocampus during memory testing. In this cross-sectional study we included 19 women previously treated for CS and 19 controls matched for age, gender, and education. The median remission time was...

article

Maintained memory in aging is associated with young epigenetic age

Sofie Degerman, Maria Josefsson, Annelie Nordin Adolfsson, Sigrid Wennstedt, more

Neurobiology of Aging > 2017 > 55 > C > 167-171

Epigenetic alterations during aging have been proposed to contribute to decline in physical and cognitive functions, and accelerated epigenetic aging has been associated with disease and all-cause mortality later in life. In this study, we estimated epigenetic age dynamics in groups with different memory trajectories (maintained high performance, average decline, and accelerated decline) over a 15-year...

article

Short-term olfactory sensitization involves brain networks relevant for pain, and indicates chemical intolerance

Linus Andersson, Anna-Sara Claeson, Lars Nyberg, Steven Nordin

International Journal of Hygiene and Environmental Health > 2017 > 220 > 2(PB) > 503-509

Chemical intolerance is a medically unexplained affliction that implies deleterious reactions to non-toxic everyday chemical exposure. Sensitization (i.e. increased reactivity to repeated, invariant stimulation) to odorous stimulation is an important component in theoretical explanations of chemical intolerance, but empirical evidence is scarce. We hypothesized that (1) individuals who sensitize to...

article

A genetic association study of CSMD1 and CSMD2 with cognitive function

Lavinia Athanasiu, Sudheer Giddaluru, Carla Fernandes, Andrea Christoforou, more

Brain, Behavior, and Immunity > 2017 > 61 > C > 209-216

The complement cascade plays a role in synaptic pruning and synaptic plasticity, which seem to be involved in cognitive functions and psychiatric disorders. Genetic variants in the closely related CSMD1 and CSMD2 genes, which are implicated in complement regulation, are associated with schizophrenia. Since patients with schizophrenia often show cognitive impairments, we tested whether variants in...

article

Assessment of pluvial flood exposure and vulnerability of residential areas

Tonje Grahn, Lars Nyberg

International Journal of Disaster Risk Reduction > 2017 > 21 > C > 367-375

Floods are a large problem around the world but the understanding of flood risks is hampered by a lack of data and knowledge about flood losses at different scales. The objective of this study was two-fold 1) to assess available temporally and spatially distributed data of rain events and flood damages during those events, regarding the usefulness of these data to quantify precipitation-related hazards...

article

Longitudinal association between hippocampus atrophy and episodic-memory decline

Tetiana Gorbach, Sara Pudas, Anders Lundquist, Greger Orädd, more

Neurobiology of Aging > 2017 > 51 > C > 167-176

There is marked variability in both onset and rate of episodic-memory decline in aging. Structural magnetic resonance imaging studies have revealed that the extent of age-related brain changes varies markedly across individuals. Past studies of whether regional atrophy accounts for episodic-memory decline in aging have yielded inconclusive findings. Here we related 15-year changes in episodic memory...

article

Effective and Sustainable Flood and Landslide Risk Reduction Measures: An Investigation of Two Assessment Frameworks

Yvonne Andersson-Sköld, Lars Nyberg

International Journal of Disaster Risk Science > 2016 > 7 > 4 > 374-392

Natural events such as floods and landslides can have severe consequences. The risks are expected to increase, both as a consequence of climate change and due to increased vulnerabilities, especially in urban areas. Although preventive measures are often cost-effective, some measures are beneficial to certain values, while some may have negative impacts on other values. The aim of the study presented...

article

White matter integrity as a marker for cognitive plasticity in aging

Ann-Marie Glasø de Lange, Anne Cecilie Sjøli Bråthen, Håkon Grydeland, Claire Sexton, more

Neurobiology of Aging > 2016 > 47 > C > 74-82

Age-related differences in white matter (WM) integrity are substantial, but it is unknown whether between-subject variability in WM integrity influences the capacity for cognitive improvement. We investigated the effects of memory training related to active and passive control conditions in older adults and tested whether WM integrity at baseline was predictive of training benefits. We hypothesized...

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INFONA - science communication portal

Search results for: Lars Nyberg

5‐Year Associations among Cerebral Arterial Pulsatility, Perivascular Space Dilation, and White Matter Lesions

Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years

Greater male than female variability in regional brain structure across the lifespan

Effects of copy number variations on brain structure and risk for psychiatric illness: Large‐scale studies from the ENIGMA working groups on CNVs

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years

Mapping the landscape of human dopamine D2/3 receptors with [¹¹C]raclopride

The Cone Evasion Walk test: Reliability and validity in acute stroke

Working memory training mostly engages general-purpose large-scale networks for learning

The retrosplenial cortex: A memory gateway between the cortical default mode network and the medial temporal lobe

Cognitive medicine – a new approach in health care science

Cognitive control in the prefrontal cortex: A central or distributed executive?

Both psychological factors and physical performance are associated with fall-related concerns

Decreased prefrontal functional brain response during memory testing in women with Cushing’s syndrome in remission

Maintained memory in aging is associated with young epigenetic age

Short-term olfactory sensitization involves brain networks relevant for pain, and indicates chemical intolerance

A genetic association study of CSMD1 and CSMD2 with cognitive function

Assessment of pluvial flood exposure and vulnerability of residential areas

Longitudinal association between hippocampus atrophy and episodic-memory decline

Effective and Sustainable Flood and Landslide Risk Reduction Measures: An Investigation of Two Assessment Frameworks

White matter integrity as a marker for cognitive plasticity in aging

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